Citation Impact
Citing Papers
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
2005 Standout
A gene atlas of the mouse and human protein-encoding transcriptomes
2004 Standout
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Transcriptional Regulation by Nrf2
2017 Standout
Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies
2013
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
2009 Standout
The multifaceted role of Nrf2 in mitochondrial function
2016
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
2010
Structural basis of Keap1 interactions with Nrf2
2015
Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
2017
Identification of Candidate Proteins Binding to Prion Protein
1997 StandoutNobel
Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes
2016
AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis
1996 Standout
Positive or Negative MARE-Dependent Transcriptional Regulation Is Determined by the Abundance of Small Maf Proteins
2000
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
2013 StandoutNobel
Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation bytert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult
2004
Heme Oxygenase-1 in Tumor Biology and Therapy
2010
Correlation of Nrf2, HO-1, and MRP3 in Gallbladder Cancer and Their Relationships to Clinicopathologic Features and Survival
2010
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
2006
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 Standout
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
1997 Standout
Inflammation and metabolic disorders
2006 StandoutNature
NRF2-regulation in brain health and disease: Implication of cerebral inflammation
2013
Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells
2001
Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
2016
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
2001
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR‐dependent motor neuron apoptosis
2006
Methylation of the KEAP1 gene promoter region in human colorectal cancer
2012
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions
2013 StandoutNature
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
2006 Standout
Chemoprotection by Organosulfur Inducers of Phase 2 Enzymes: Dithiolethiones and Dithiins
2000
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells
2019
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
2000
Nrf2-Keap1 signaling in oxidative and reductive stress
2018 Standout
Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells
2012
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
2022 StandoutNobel
Nrf2: bane or blessing in cancer?
2014
Inhibition of the 26S Proteasome Induces Expression of GLCLC, the Catalytic Subunit for γ-Glutamylcysteine Synthetase
2000
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
2003 Standout
Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
2012 Standout
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Nrf1 Is Targeted to the Endoplasmic Reticulum Membrane by an N-terminal Transmembrane Domain
2006
The world according to Maf
1997
Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase
2017
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
2011
The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents
1999
Silver nanoparticles down-regulate Nrf2-mediated 8-oxoguanine DNA glycosylase 1 through inactivation of extracellular regulated kinase and protein kinase B in human Chang liver cells
2011
Nrf2-deficient female mice develop lupus-like autoimmune nephritis11See Editorial by Byrd and Thomas, p. 1606.
2001
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1
1996
Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol
2004
Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts
2010
How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo
2013
High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes
2001
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
2003
Multiorgan Autoimmune Inflammation, Enhanced Lymphoproliferation, and Impaired Homeostasis of Reactive Oxygen Species in Mice Lacking the Antioxidant-Activated Transcription Factor Nrf2
2006
Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells
2000
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2
2004
Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
2017
Specific Patterns of Electrophile Adduction Trigger Keap1 Ubiquitination and Nrf2 Activation
2005
Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress
2003
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
2005
Regulation of NF-E2 Activity in Erythroleukemia Cell Differentiation
1998
Transcriptional Regulation of the Antioxidant Response Element
2000
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
Impaired megakaryopoiesis and behavioral defects inmafG-null mutant mice
1998
The emerging role of the Nrf2–Keap1 signaling pathway in cancer
2013
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Transcriptional responses to oxidative stress: Pathological and toxicological implications
2009
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
2003
The cytoprotective role of the Keap1–Nrf2 pathway
2011
Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium
2003
Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells
2010
Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1
2005
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Molecular mechanisms of Nrf2‐mediated antioxidant response
2008
Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3
1999
Somatic mutations of the KEAP1 gene in common solid cancers
2012
Characterization of the Hematopoietic Transcription Factor NF-E2 in Primary Murine Megakaryocytes
1998
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2
2006
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress
2012
Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles
2003
Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
1998
Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response
2012
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation
2009
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
2009
Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
2014
Transcription Factors and Hematopoietic Development
1995
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes
1997
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
2003
NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons
2003
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
2014 Standout
Regulatory mechanisms of cellular response to oxidative stress
1999
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
2006
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
2012
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
2002
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
1997 Standout
Regulatory Motifs for CREB-binding Protein and Nfe2l2 Transcription Factors in the Upstream Enhancer of the Mitochondrial Uncoupling Protein 1 Gene
2002
Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
2014
Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element
2003
Accelerated DNA Adduct Formation in the Lung of the Nrf2 Knockout Mouse Exposed to Diesel Exhaust
2001
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
2001
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors
2011
Idiopathic pulmonary fibrosis
2011 Standout
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
1999
Oxidative stress response and Nrf2 signaling in aging
2015
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
2001
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
1998
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2
2002
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
2001 Standout
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events
2016
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity
2013
Regulation of Nrf2 Transactivation Domain Activity
2004
Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2
1999
Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells
2019
Hemin-induced Activation of the Thioredoxin Gene by Nrf2
2001
Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury
2008
Nrf2 regulates haematopoietic stem cell function
2013
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
2007 Standout
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
2002
The NRF2‐related interactome and regulome contain multifunctional proteins and fine‐tuned autoregulatory loops
2012
Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)
2015
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
2011
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
2004
Endogenous Hydrogen Peroxide Regulates Glutathione Redox via Nuclear Factor Erythroid 2-Related Factor 2 Downstream of Phosphatidylinositol 3-Kinase during Muscle Differentiation
2008
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription
1998
Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
2014
Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease
2012
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
2006
Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2
2007
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
2011
Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease
2011
Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets
2013
Role of Bach1 and Nrf2 in up‐regulation of the heme oxygenase‐1 gene by cobalt protoporphyrin
2006
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model
2006
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
2002 Standout
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription
2002
Xenobiotic-Activated Receptors: From Transcription to Drug Metabolism to Disease
2008
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
2003
Accurate MALDI-TOF/TOF Sequencing of One-Bead−One-Compound Peptide Libraries with Application to the Identification of Multiligand Protein Affinity Agents Using in Situ Click Chemistry Screening
2009
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene
2006
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
2003
Erythroid Maturation and Globin Gene Expression in Mice With Combined Deficiency of NF-E2 and Nrf-2
1998
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
2009
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
2017
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
2016
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
2003
Understanding the role of NRF2-regulated miRNAs in human malignancies
2013
Cancer Cell Cycles
1996 StandoutScience
Locus control regions
2002
Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
2004
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
2006 Standout
Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
2013
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
2004
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Brown Adipose Tissue: Function and Physiological Significance
2004 Standout
Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.
1995
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
1996
Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development
2003
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
Nrf2 is essential for protection against acute pulmonary injury in mice
1999
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Genetic variants of nuclear factor erythroid‐derived 2‐like 2 associated with the complications in Han descents with type 2 diabetes mellitus of Northeast China
2016
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound
2002
Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione
2001
Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
2011
The transcriptional control of hematopoiesis [see comments]
1996
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
2010
Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
2007
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
2001
Nrf2 Is Essential for the Chemopreventive Efficacy of Oltipraz against Urinary Bladder Carcinogenesis
2004
Small Maf Proteins Heterodimerize with Fos and May Act as Competitive Repressors of the NF-E2 Transcription Factor
1995
Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site
1996
Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins
1995
NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2
2013
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
2010
Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?
2007
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene
1996 Standout
The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus
2013
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
2001
Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element
2003
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.
2001
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
2004
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
2017 StandoutNobel
Accelerated Ovarian Failure Induced by 4-Vinyl Cyclohexene Diepoxide in Nrf2 Null Mice
2006
Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes
2005
Works of Anthony Chan being referenced
High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans
2006
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.
1994