Standout Papers
Citation Impact
Citing Papers
Selective Activation of Adenosine A 2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis
2012
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
2009
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis
2009
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Structural insight into the TFIIE–TFIIH interaction: TFIIE and p53 share the binding region on TFIIH
2008
Identification of cis-Acting Elements That Can Obviate a Requirement for the C-terminal Domain of RNA Polymerase II
1995
Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy
2007
From molecular to modular cell biology
1999 StandoutNatureNobel
TFIIH: a key component in multiple DNA transactions
1996
Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.
1993
The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin
2005 Standout
The Role of Human TFIIB in Transcription Start Site Selection in Vitro and in Vivo
1999
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Evidence That Transcription Factor IIB Is Required for a Post-assembly Step in Transcription Initiation
1999
Phosphorylation of the C-terminal domain of RNA polymerase II
1995
Cellular function and molecular structure of ecto-nucleotidases
2012
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
1993
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Eukaryotic Promoter Recognition
1997
Nucleotide signalling during inflammation
2014 StandoutNature
Structural basis of preinitiation complex assembly on human Pol II promoters
2000
Tumor spectrum analysis in p53-mutant mice
1994 Standout
Extracellular adenosine triphosphate and adenosine in cancer
2010
Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription
1993 Nature
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
1993 Nature
Regulatory T cells and infection: a dangerous necessity
2007
Structural studies of a synthetic peptide derived from the carboxyl‐terminal domain of RNA polymerase II
1995
Crystal structure of a yeast TFIIA/TBP/DNA complex
1996 Nature
Recycling of the general transcription factors during RNA polymerase II transcription.
1995
Mapping the Location of TFIIB within the RNA Polymerase II Transcription Preinitiation Complex
2004
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Binding of TFIIB to RNA Polymerase II
2003
Topology and reorganization of a human TFIID–promoter complex
1996 Nature
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID
1992
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
2011
Hypoxia and Inflammation
2011 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response
2009
New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB
1998
The Hallmarks of Cancer
2000 Standout
Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells
1993 Nature
Regulation of gene expression by TBP-associated proteins
1998
RNA polymerase II–TFIIB structure and mechanism of transcription initiation
2009 Nature
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast
1994 StandoutNatureNobel
Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 Å resolution 1 1Edited by K. Nagai
2000
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
The C-terminal Domain Revealed in the Structure of RNA Polymerase II
1996 StandoutNobel
A DNA-tethered cleavage probe reveals the path for promoter DNA in the yeast preinitiation complex
2006
Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
2009
Structural similarity between TAFs and the heterotetrameric core of the histone octamer
1996 Nature
Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface
2000
Structure and mechanism of the RNA polymerase II transcription machinery
2004
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
2007
Regulatory T cells: how do they suppress immune responses?
2009 StandoutNobel
How regulatory T cells work
2008 Standout
Architectural Transcription Factors: Proteins That-Remodel DNA
1997
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
A Yeast Four-hybrid System Identifies Cdk-activating Kinase as a Regulator of the XPD Helicase, a Subunit of Transcription Factor IIH
2001
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair
1993 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
General Transcription Factors for RNA Polymerase II1
1997
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Induction of T cell anergy: integration of environmental cues and infectious tolerance
2010
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
2009 Nature
Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? 1 1Edited by R. Ebright
2000
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A–induced hepatitis
2008
What We Talk About When We Talk About Fat
2014 Standout
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription
2000
Effects of activation-defective TBP mutations on transcription initiation in yeast
1994 StandoutNatureNobel
The general transcription factors of RNA polymerase II.
1996
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
1992 Nature
CD39/Adenosine Pathway Is Involved in AIDS Progression
2011
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
1997
Two-Dimensional Crystallography of TFIIB– and IIE–RNA Polymerase II Complexes: Implications for Start Site Selection and Initiation Complex Formation
1996 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
DNA structure in human RNA polymerase II promoters 1 1Edited by J. Karn
1998 StandoutNobel
Genome editing with engineered zinc finger nucleases
2010 Standout
Activation of the cryptic DNA binding function of mutant forms of p53
1993
The Human Apoptosis-inducing Protein AMID Is an Oxidoreductase with a Modified Flavin Cofactor and DNA Binding Activity
2005
Purinergic Signaling during Inflammation
2012
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Protein traffic on the heat shock promoter: Parking, stalling, and trucking along
1993
Mitotic repression of the transcriptional machinery
1997
Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation
1994 Nature
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
2008 StandoutScienceNobel
DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor
1993 Science
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery
2011
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
Immune cell regulation by autocrine purinergic signalling
2011
RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.
1993
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.
1993
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
2007
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
The role of general initiation factors in transcription by RNA polymerase II
1996
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
2007
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
p53 and E2F-1 cooperate to mediate apoptosis.
1994
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
1993
The structural basis for the oriented assembly of a TBP/TFB/promoter complex
1999
The p53-mdm-2 autoregulatory feedback loop.
1993 Standout
New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting
2009
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.
1994
Core Promoter-Dependent TFIIB Conformation and a Role for TFIIB Conformation in Transcription Start Site Selection
2002
Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.
1994
Considerations of transcriptional control mechanisms: Do TFIID–core promoter complexes recapitulate nucleosome-like functions?
1997
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
The molecular basis of eukaryotic transcription
2007 Nobel
Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II.
1994
Conserved Structures of Mediator and RNA Polymerase II Holoenzyme
1999 StandoutScienceNobel
The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription
1993
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Mass Spectrometry as a Tool for Protein Crystallography
2001
Crystal Structure of the Yeast TFIIA/TBP/DNA Complex
1996 Science
A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors.
1994
The N-terminal Region of Yeast TFIIB Contains Two Adjacent Functional Domains Involved in Stable RNA Polymerase II Binding and Transcription Start Site Selection
1998
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Mutational Analysis of the D1/E1 Core Helices and the Conserved N-Terminal Region of Yeast Transcription Factor IIB (TFIIB): Identification of an N-terminal Mutant That Stabilizes TATA-Binding Protein-TFIIB-DNA Complexes
1997
A Highly Conserved Domain of RNA Polymerase II Shares a Functional Element with Acidic Activation Domains of Upstream Transcription Factors
1994
Structure of an RNA Polymerase II–TFIIB Complex and the Transcription Initiation Mechanism
2009 ScienceNobel
Characterization of sua7 mutations defines a domain of TFIIB involved in transcription start site selection in yeast.
1994
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
Crystal structure of a human TATA box-binding protein/TATA element complex.
1996
Nuclear Import of the TATA-binding Protein: Mediation by the Karyopherin Kap114p and a Possible Mechanism for Intranuclear Targeting
1999 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
CD73 + regulatory T cells contribute to adenosine‐mediated resolution of acute lung injury
2013
The 2.1-Å crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box
1997
Trajectory of DNA in the RNA polymerase II transcription preinitiation complex
1997
Works of Anny Usheva being referenced
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
2007 Standout
A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF)
2002
CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation
2008
Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein
1992
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
2003
Crystal structure of a TFIIB–TBP–TATA-element ternary complex
1995 Nature
TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA
1994
Wild-type p53 binds to the TATA-binding protein and represses transcription.
1992
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator
1996
RanBPM associates with CD39 and modulates ecto-nucleotidase activity
2006
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
1995
Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
2012