Standout Papers
Citation Impact
Citing Papers
ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40–Mediated Tumor Rejection
2016 StandoutNobel
A heterotrimeric death domain complex in Toll signaling
2002
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation
2002 Science
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
2000
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses
2001
Identification of Two Smad4 Proteins in Xenopus
1999
Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells
2001
Chimeras and mosaics in mouse mutant analysis
1998
JunB is essential for mammalian placentation
1999
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
1999 StandoutNobel
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
2001
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
1999
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
2001 Nature
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
2006
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Smads and early developmental signaling by the TGFβ superfamily
1998
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
2003
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program
2008
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
2003
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
2001 Nature
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
2008
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Leukocytes navigate by compass: roles of PI3Kγ and its lipid products
2000
Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes
1999
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
Osteoporosis: now and the future
2011 Standout
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
2000
Intracellular Toll-like Receptors
2010 StandoutNobel
Nodal signalling in vertebrate development
2000 Nature
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
2017 StandoutNobel
No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells
2008
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Toll-like receptor signalling
2004 Standout
The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity
2003
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
2001 StandoutNobel
Lipid signalling in disease
2008
Caspase Functions in Cell Death and Disease
2013 Standout
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
1997
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses
2003
The immune response of Drosophila
2003 StandoutNatureNobel
Eukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization
2003
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
2002
Osteoclast differentiation and activation
2003 StandoutNature
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
2005 Nature
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
2009 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Signaling of transforming growth factor‐β family members through Smad proteins
2000
High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans
2006
<I>Lps2</I>: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Smad3 Mutant Mice Develop Metastatic Colorectal Cancer
1998
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
2006 StandoutNobel
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members
2003
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection
2000
Points of control in inflammation
2002 StandoutNature
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
B7-H2 Is a Costimulatory Ligand for CD28 in Human
2011
The TNF and TNF Receptor Superfamilies
2001 Standout
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
2002
RANKL Inhibition: From Mice to Men (and Women)
2007
Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis
2002
A Smad Transcriptional Corepressor
1999
Mouse gastrulation: the formation of a mammalian body plan
1997
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis
2004
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
2003 StandoutNobel
NF-κB at the crossroads of life and death
2002 Standout
Dickkopf-1 is a master regulator of joint remodeling
2007
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
The B7–CD28 superfamily
2002
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
CD95's deadly mission in the immune system
2000 Nature
Role of ICOS versus CD28 in antiviral immunity
2002
RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2
1997
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos
2000
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Haploinsufficiency of mTR results in defects in telomere elongation
2002 StandoutNobel
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
2001
The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency
2009
Role of Akt Signaling in Vascular Homeostasis and Angiogenesis
2002
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women
2004
Bone Resorption by Osteoclasts
2000 StandoutScience
A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii
2002
Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis
2002
Smad regulation in TGF-β signal transduction
2001
Double indemnity: p53, BRCA and cancer
1997
The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women
2001
THE B7 FAMILY REVISITED
2005 Standout
The Inducible Costimulator (ICOS) Is Critical for the Development of Human T H 17 Cells
2010
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
Pten is essential for embryonic development and tumour suppression
1998 Standout
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
Inducible Costimulator Protein Controls the Protective T Cell Response Against Listeria monocytogenes
2002
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
2001
Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor–mediated Pathways and Can Be Rescued by CD40 Signaling
2002
The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28
2004
ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells
2008
The future of immune checkpoint therapy
2015 StandoutScienceNobel
ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+T cells
2002
Formation of the definitive endoderm in mouse is a Smad2-dependent process
2000
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
2002
ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells
2006
B7h is required for T cell activation, differentiation, and effector function
2003
Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
2007
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2
2003
The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses
2002
Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis.
2001
Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
2000 Science
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Inducible Costimulatory Molecule-B7-Related Protein 1 Interactions Are Important for the Clonal Expansion and B Cell Helper Functions of Naive, Th1, and Th2 T Cells
2003
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
2003
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
2007 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase
2005
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Direct Neural Fate Specification from Embryonic Stem Cells
2001
The BRCA 2 gene product functionally interacts with p53 and RAD51
1998
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
2007
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis
2002
Works of Annick Itié being referenced
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
1998
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
2000
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
2000
Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
2000
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
1999
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
2000 Nature
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
1999 StandoutNature
ICOS is essential for effective T-helper-cell responses
2001 Nature
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
2002 Nature
Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice
2006
Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
1999
Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo
2000
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel