Standout Papers
Citation Impact
Citing Papers
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Distinct fibroblast lineages determine dermal architecture in skin development and repair
2013 StandoutNature
Whole-genome resequencing reveals loci under selection during chicken domestication
2010 StandoutNature
Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq
2018 Science
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
2015
Fgf8is required for pharyngeal arch and cardiovascular development in the mouse
2002
Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling
2003
Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge
2003
The complexities of skeletal biology
2003 StandoutNature
Hedgehog: functions and mechanisms
2008 Standout
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
2006
Fgf8 signalling from the AER is essential for normal limb development
2000
Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights
1997
Genetic effects on gene expression across human tissues
2017 StandoutNature
Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
2006
Chromatin Unfolds
1996
Co-expression networks reveal the tissue-specific regulation of transcription and splicing
2017
Efficient mapping of mendelian traits in dogs through genome-wide association
2007
The biology and management of non-small cell lung cancer
2018 StandoutNature
Feedback control of intercellular signalling in development
2000 Nature
The role of Hox genes during vertebrate limb development
2007
Long Noncoding RNAs in Cancer Pathways
2016 Standout
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Fibroblast growth factors.
2001 Standout
Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome
2003
Vertebrate limb development — the early stages in chick and mouse
2001
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features
2015 Standout
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Crystal structure of the nucleosome core particle at 2.8 Å resolution
1997 StandoutNature
Neural crest and cardiovascular development: A 20‐year perspective
2003
Making or Breaking the Heart: From Lineage Determination to Morphogenesis
2006
Long Noncoding RNAs in Cancer: From Function to Translation
2015
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Developmental regulation of the growth plate
2003 StandoutNature
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
2000 StandoutNature
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
2005 StandoutNobel
Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells
1992
Dynamical features of thePlasmodium falciparumribosome during translation
2015 StandoutNobel
The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus
1998
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
1993 Nature
A myocardial lineage derives from Tbx18 epicardial cells
2008 StandoutNature
Wnt/β-Catenin Signaling and Disease
2012 Standout
The Microprocessor complex mediates the genesis of microRNAs
2004 StandoutNature
To be or not to be active: the stochastic nature of enhancer action
2000
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
2005
Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses
2016
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
2003 StandoutNature
A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
1993
Tbx1is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer
2003
Building the mammalian heart from two sources of myocardial cells
2005
Regulation of β-globin gene expression: straightening out the locus
1996
Oncolytic viruses: adenoviruses
2017
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
Klotho converts canonical FGF receptor into a specific receptor for FGF23
2006 StandoutNature
Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart
2003 Standout
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
Pattern formation: old models out on a limb
2003
Converging Pathways and Principles in Heart Development and Disease
2002
Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry
2004 StandoutNobel
Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
2007
22q11.2 deletion syndrome
2015 Standout
Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx
2006
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
2002
Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
2007
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
In Vivo and In Vitro Tissue‐Specific Expression of Green Fluorescent Protein Using the Cre‐Lox System in Mouse Embryonic Stem Cells
2005 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Tbx1expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
2005
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
2013
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
1998
EctodermalWnt3/β-cateninsignaling is required for the establishment and maintenance of the apical ectodermal ridge
2003 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Multiple roles ofHoxa11andHoxd11in the formation of the mammalian forelimb zeugopod
2003 StandoutNobel
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
2003
Patterning Mechanisms Controlling Vertebrate Limb Development
2001
Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell–Based Regeneration
2010 StandoutNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
1997 StandoutNobel
Heart Valve Development
2009
Stochastic Gene Expression in a Single Cell
2002 StandoutScience
Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development
2007
Metabolic reprogramming and cancer progression
2020 StandoutScience
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
1995
Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment
2007 StandoutNobel
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
2011 Standout
Viral Vectors for Gene Therapy: Translational and Clinical Outlook
2015
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
1993 StandoutNobel
Characterization of the chicken β-globin insulator
1997
A mouse model for beta 0-thalassemia.
1995 StandoutNobel
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
2007
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension
1995 StandoutScienceNobel
Altering mice by homologous recombination using embryonic stem cells.
1994 StandoutNobel
An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.
1993
Oncolytic Viruses in Cancer Treatment
2016
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation
2006 StandoutNobel
Islet1 cardiovascular progenitors: a single source for heart lineages?
2007
Fgf8is required for anterior heart field development
2006
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud
2001
Works of Anne Moon being referenced
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development
2003
Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
2013
A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma
2011
Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients
2014
Fgf8 is required for outgrowth and patterning of the limbs
2000 StandoutNobel
Crkl Deficiency Disrupts Fgf8 Signaling in a Mouse Model of 22q11 Deletion Syndromes
2006
The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth
2004 StandoutNobel
FGF8 initiates inner ear induction in chick and mouse
2005
Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer
2015
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
2014
Hox genes define distinct progenitor sub-domains within the second heart field
2011 Nobel
Structure and function of the murine β-globin locus control region 5′ HS-3
1992
TBX3 Regulates Splicing In Vivo: A Novel Molecular Mechanism for Ulnar-Mammary Syndrome
2014
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial
2008
Frs2α-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis
2008
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulatingGbx2expression in the pharyngeal ectoderm
2009
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
2007
Normal limb development in conditional mutants of Fgf4
2000 StandoutNobel
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart
2008
AnFgf8mouse mutant phenocopies human 22q11 deletion syndrome
2002 StandoutNobel
Complementation analysis of fatty acid oxidation disorders.
1987
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells
1991
Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy
2011
Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans
2013
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
2006
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex
2014
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
1990