Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
2013 StandoutScience
[18F](2 S ,4 R )4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition
2017
mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer
2015
Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate
2015
Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1α
2010
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
2019 Science
SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
2012 Science
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
2014
Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
2013
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Tumor-selective catalytic nanomedicine by nanocatalyst delivery
2017
Glucose-dependent de Novo Lipogenesis in B Lymphocytes
2014
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
2015
Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities
2024 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Mitochondria as biosynthetic factories for cancer proliferation
2015
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
2013
ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
2013
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms
2010
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
2015
Alterations of metabolic genes and metabolites in cancer
2012
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
2014 Nature
mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells
2016
Targeting cancer metabolism: a therapeutic window opens
2011
MYC on the Path to Cancer
2012 Standout
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
2011
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling
2014
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
2012 Standout
Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines
2015
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine
2011
Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
2015
A guide to immunometabolism for immunologists
2016 Standout
Glutamine and cancer: cell biology, physiology, and clinical opportunities
2013
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
2012
Acetate Dependence of Tumors
2014
Targeting glutamine metabolism in myeloproliferative neoplasms
2015
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
2013
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
2014
Links between metabolism and cancer
2012
Comparative Evaluation of 18F-Labeled Glutamic Acid and Glutamine as Tumor Metabolic Imaging Agents
2012
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
2016 Nature
Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
2016
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
2014
Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells
2015
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Pancreatic Adenocarcinoma
2014 Standout
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
2014
The PI3K pathway in B cell metabolism
2016
Impact of MYC in regulation of tumor cell metabolism
2014
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Control of glutamine metabolism by the tumor suppressor Rb
2013
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
2011
Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells
2016
Famine versus feast: understanding the metabolism of tumors in vivo
2015
Regulation of cancer cell metabolism
2011 Standout
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
2015
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
The consequences of enhanced cell-autonomous glucose metabolism
2012
MYC Activation Is a Hallmark of Cancer Initiation and Maintenance
2014
13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression
2011
A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels
2014
Autophagy in Human Health and Disease
2013 Standout
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
2014
Mitochondria in the Regulation of Innate and Adaptive Immunity
2015
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Proline dehydrogenase (oxidase) in cancer
2012
Proline metabolism and cancer
2014
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
2012
The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis
2011
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
2014
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
A two-way street: reciprocal regulation of metabolism and signalling
2012
The Warburg Effect: How Does it Benefit Cancer Cells?
2016 Standout
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
2015
The PI3K Pathway in Human Disease
2017 Standout
Targeting lactate metabolism for cancer therapeutics
2013
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
2015
Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
2014
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
2013
Targeting mitochondria metabolism for cancer therapy
2014
Metabolic pathways promoting cancer cell survival and growth
2015
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
2014
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
2018 StandoutNobel
Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
2014
Redox control of glutamine utilization in cancer
2014
Effects of hypoxia and HIFs on cancer metabolism
2012
Research into cancer metabolomics: Towards a clinical metamorphosis
2015
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
2014
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Regulation of mammalian nucleotide metabolism and biosynthesis
2015
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice
2018
Fundamentals of cancer metabolism
2016 Standout
Targeting MYC-Regulated miRNAs to Combat Cancer
2010
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
2015 StandoutNobel
Cancer Cell Metabolism: One Hallmark, Many Faces
2012
Identification of an Autophagy Defect in Smokers’ Alveolar Macrophages
2010
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
2011 StandoutNobel
The Pancreas Cancer Microenvironment
2012
Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
2015
Spermidine in health and disease
2018 StandoutScience
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
MYC, Metabolism, and Cancer
2015
Metabolic reprogramming and cancer progression
2020 StandoutScience
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch
2016
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
2015
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Spermidine alleviates oxidative stress in silk glands of Bombyx mori
2016
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
2014
Translational Therapeutic Opportunities in Ductal Adenocarcinoma of the Pancreas
2012
Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
2012
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
2013 Science
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
2018
KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment
2016
Genetics and biology of pancreatic ductal adenocarcinoma
2016
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
2015
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
A key role for transketolase-like 1 in tumor metabolic reprogramming
2016
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits
2014
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
2014
Works of Anne Le being referenced
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
2015
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
2012
Therapeutic targeting of cancer cell metabolism
2011
Pulmonary Epithelial Neuropilin-1 Deletion Enhances Development of Cigarette Smoke–induced Emphysema
2009
Discovery of 6-Diazo-5-oxo-l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma
2016
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
2012
Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter
2014
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
2009
Conceptual Framework for Cutting the Pancreatic Cancer Fuel Supply
2012
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
2010
Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
2013
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
2014