Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
2002 StandoutScience
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
1997 StandoutScience
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Activating Smoothened mutations in sporadic basal-cell carcinoma
1998 StandoutNature
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
2017 StandoutNobel
WNT5A mutations in patients with autosomal dominant Robinow syndrome
2009
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
1999 StandoutNature
Sonic hedgehog is essential to foregut development
1998
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
The patched signaling pathway in tumorigenesis and development: lessons from animal models
1999
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
1999
Hedgehog and Patched in Neural Development and Disease
1998
Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors
2016
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
2004
Lung Cancer
2008 Standout
The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
2000
The Hedgehog's tale: developing strategies for targeting cancer
2011
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
2008 Nature
The hedgehog signaling network
2003
Neural-Tube Defects
1999 Standout
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
2002 StandoutScience
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
Effective targeted gene ‘knockdown’ in zebrafish
2000 Standout
The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly
1999
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22
1997
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
1997 Standout
Eye Development and Retinogenesis
2012
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
2009 Standout
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
New players and puzzles in the Hedgehog signaling pathway
1998
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
2000 StandoutNature
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
2003 StandoutNature
X-chromosome inactivation: counting, choice and initiation
2001
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
2001 StandoutNobel
Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid
1997
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Recent advances in hedgehog signalling
1997
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
1997 Nature
Gata5 is required for the development of the heart and endoderm in zebrafish
1999
The hormone resistin links obesity to diabetes
2001 StandoutNature
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
2010 Standout
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
Chapter 13 Long‐Range Gene Control and Genetic Disease
2008
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
1998 Standout
Molecular Mechanisms of Holoprosencephaly
1999
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
2007
Mature ovarian cystic teratoma with a highly differentiated homunculus: A case report
2003
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
The hedgehog pathway and basal cell carcinomas
2001
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
The patched gene in development and cancer
1998
Spatial partitioning of the regulatory landscape of the X-inactivation centre
2012 StandoutNature
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
A Novel Mutation of desert hedgehog in a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development.
1997
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Reconstitution of I KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor
1995 StandoutScience
Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy
1995 Science
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
1998
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
1998
GENETICS OF NON-INSULIN-DEPENDENT (TYPE-II) DIABETES MELLITUS
1996
Regulation of retinal ganglion cell production by Sonic hedgehog
2001
Hedgehog Signaling and Human Disease
2002
Signalling interactions during facial development
1998
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
2005
ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway
2004 Science
A Novel Mutation ofdesert hedgehogin a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Regulation of pancreas development by hedgehog signaling
2000
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.
1997
Congenital Malformations
1953 Standout
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
1997 StandoutScience
Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man
1974 StandoutScienceNobel
SMART, a simple modular architecture research tool: Identification of signaling domains
1998 Standout
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Anne Hing being referenced
Mapping the human liver/islet glucose transporter (GLUT2) gene within a genetic linkage map of chromosome 3q using a (CA)n dinucleotide repeat polymorphism and characterization of the polymorphism in three racial groups
1992
A Physical and Transcriptional Map of the Preaxial Polydactyly Locus on Chromosome 7q36
1999
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
1996 Standout
“Mandibulofacial dysostosis with microcephaly” caused by EFTUD2 mutations: Expanding the phenotype
2012
Fetus in fetu:Molecular analysis of a fetiform mass
1993
Linkage of preaxial polydactyly type 2 to 7q36
1995
Two chromosome 7 dinucleotide repeat polymorphisms at gene loci epidermal growth factor receptor (EGFR) and proα2 (1) collagen (COL1A2)
1992
Robin Sequence: From Diagnosis to Development of an Effective Management Plan
2011
GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease
1999
GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease
1999