Standout Papers
Citation Impact
Citing Papers
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
2009 StandoutScience
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
2013 Science
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Cutting Edge: K63-Linked Polyubiquitination of NEMO Modulates TLR Signaling and Inflammation In Vivo
2008
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
In search of the tumour-suppressor functions of BRCA1 and BRCA2
2000 Nature
Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand
1997
Active genes dynamically colocalize to shared sites of ongoing transcription
2004
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks
2001
PI3Kδ and primary immunodeficiencies
2016
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
1999 StandoutNobel
TNF Inhibitors are Produced Spontaneously by Rheumatoid and Osteoarthritic Synovial Joint Cell Cultures: Evidence of Feedback Control of TNF Action
1995
The biochemistry of activation-induced deaminase and its physiological functions
2012
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
2010
Akt and mTOR in B Cell Activation and Differentiation
2012
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Chromosomal Rearrangements Occur in S. cerevisiae rfa1 Mutator Mutants Due to Mutagenic Lesions Processed by Double-Strand-Break Repair
1998
PI3K signalling in inflammation
2014
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
2013
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Chromatin Modifications and Their Function
2007 Standout
Diverse functions for DNA and RNA editing in the immune system
2010
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
2010
Replication and transcription: Shaping the landscape of the genome
2005
A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination
1998
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
2009 StandoutNature
Genetic instabilities in human cancers
1998 StandoutNature
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
The IL-7 Receptor Controls the Accessibility of the TCRγ Locus by Stat5 and Histone Acetylation
2001 StandoutNobel
DNA repair pathways as targets for cancer therapy
2008
Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells
2011
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α
1992
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin
2000
BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion?
1998
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
2005
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Induction of Germline Transcription in the TCRγ Locus by Stat5
1999 StandoutNobel
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
2008
The PI3K pathway in B cell metabolism
2016
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
2010
RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells
2003
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Double-Strand Break Repair Deficiency and Radiation Sensitivity in BRCA2 Mutant Cancer Cells
1998
Immunity, Inflammation, and Cancer
2010 Standout
Helper T Cell Differentiation Is Controlled by the Cell Cycle
1998
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
2001
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
2003
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
2016
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
1997 Standout
AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations
2009
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
2008
Meiotic recombination in Caenorhabditis elegans
2007
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Gene regulation through nuclear organization
2007
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
2004 Nature
Myeloid Lineage Commitment from the Hematopoietic Stem Cell
2007
Chromosome Breaks and Genomic Instability
2000
Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer
2011
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
2002
Mechanisms promoting translocations in editing and switching peripheral B cells
2009 Nature
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases
1992
The PI3K Pathway in Human Disease
2017 Standout
Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein
2001
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
2012 Standout
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
Comprehensive Integration of Single-Cell Data
2019 Standout
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
CTCF: Master Weaver of the Genome
2009 Standout
AID Targeting in Antibody Diversity
2011
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
2012 Nature
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
2013 Nature
High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans
2011
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition
2002
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
2009
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
1996 Standout
Induction of Germline Transcription in the Human TCRγ Locus by STAT5
2001 StandoutNobel
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment
2008
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
The Biochemistry of Somatic Hypermutation
2008
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage pannus junction
1991
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Foxp3+ Treg cells in humoral immunity
2013 StandoutNobel
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Amino-Terminal Phosphorylation of Activation-Induced Cytidine Deaminase Suppresses c-myc/IgH Translocation
2010
Brca1 Controls Homology-Directed DNA Repair
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells
2001 StandoutNobel
Works of Anne E. Corcoran being referenced
Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh
2007
Local and Global Epigenetic Regulation of V(D)J Recombination
2011
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
Antisense intergenic transcription in V(D)J recombination
2004
Characterization of ligand binding by the human p55 tumour‐necrosis‐factor receptor
1994
Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
1998 Nature
AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations
2008
Cytokine Assays: Role in Evaluation of the Pathogenesis of Autoimmunity
1991
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
2010
Antisense Intergenic Transcription Precedes Igh D-to-J Recombination and Is Controlled by the Intronic Enhancer Eμ
2007
Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′DQ52 Region in Targeting DHJH Recombination
2006
The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.
1996
Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.
1991
Complete Sequence Assembly and Characterization of the C57BL/6 Mouse Ig Heavy Chain V Region
2006