Standout Papers
Citation Impact
Citing Papers
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
2012 Science
Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota
2012 Science
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
2010
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
2013
From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
2013
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The thickness of the intestinal mucous layer in the colon of rats fed various sources of non-digestible carbohydrates is positively correlated with the pool of SCFA but negatively correlated with the proportion of butyric acid in digesta
2009
Relationship between the transforming and transcriptional regulatory functions of adenovirus 2 E1a oncogene
1987
Mucin dynamics and enteric pathogens
2011
Mucins in cancer: function, prognosis and therapy
2009
Expression of the SV40 promoter in fission yeast: Identification and characterization of an AP-1-like factor
1988 StandoutNobel
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
1988 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
Host tissue determinants of tumour immunity
2019
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
1990
Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles
2015
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Genetic Ablation and Restoration of the Olfactory Topographic Map
2000 StandoutNobel
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
2016 Standout
An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120
1989
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates
2014
Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity
1990 StandoutNobel
Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH
2011
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
The outer mucus layer hosts a distinct intestinal microbial niche
2015
Inflammatory Bowel Disease
2009 Standout
Cellular targets for transformation by the adenovirus E1A proteins
1989
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
1988 StandoutNature
Role of the Microbiota in Immunity and Inflammation
2014 Standout
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
KLF4, p21 and context-dependent opposing forces in cancer
2005
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
2000 StandoutNobel
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
p21 in cancer: intricate networks and multiple activities
2009 Standout
Intestinal mucosal barrier function in health and disease
2009 Standout
Quantitative Imaging of Gut Microbiota Spatial Organization
2015
The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
1988
mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect
1996
Migrating cancer stem cells — an integrated concept of malignant tumour progression
2005
Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice
2014
Glycosylation in health and disease
2019
Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy
2003
Immune adaptations that maintain homeostasis with the intestinal microbiota
2010
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cδ-mediated phosphorylation
2007
Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
2006
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
2002
Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria
2010
The gastrointestinal mucus system in health and disease
2013
Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice
2011
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma
2006
Citrobacter rodentium: infection, inflammation and the microbiota
2014
The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor
1990
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses
2009
Intestinal microbiota: Shaping local and systemic immune responses
2011
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation
2011
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
2012
Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases
2008
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
1989
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products
1987 StandoutNobel
Gut Microbiota in Health and Disease
2010 Standout
Genetic effects of methyl benzimidazole-2-yl-carbamate on Saccharomyces cerevisiae.
1982
Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion
2004 Standout
A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes.
1985
Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides
1985
Lytic and transforming functions of individual products of the adenovirus E1A gene
1986 StandoutNobel
The interaction of daunorubicin and doxorubicin with DNA and chromatin
1980
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
2002
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.
1987
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.
1988
ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
2005
The release of growth arrest by microinjection of adenovirus E1A DNA.
1985
An adenovirus E1a protein region required for transformation and transcriptional repression
1986
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
1990
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
1986 StandoutNobel
Requirement of FGF-4 for Postimplantation Mouse Development
1995 Science
Regulated expression of a diphtheria toxin A-chain gene transfected into human cells: possible strategy for inducing cancer cell suicide.
1986
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
2014
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.
1986
Single-strand DNA breaks induced by chromophore-modified anthracyclines in P388 leukemia cells.
1986
The human β-interferon gene enhancer is under negative control
1986
Molecular structural effects involved in the interaction of anthracyclines with DNA
1979
Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!
2011
The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
1988 StandoutScienceNobel
Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.
1987 StandoutNobel
Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments.
1988
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Effect of the methylation of aglycone hydroxyl groups on the biological and biochemical properties of daunorubicin
1981
Negative regulation of viral enhancers in undifferentiated embryonic stem cells
1985
Controlling mRNA lifespan
1988 StandoutNatureNobel
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products
1985 Science
Host-microbiota interactions in inflammatory bowel disease
2012
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells.
1986
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter
1987 StandoutNobel
Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
2001
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
1986 Standout
Regulation of Inducible and Tissue-Specific Gene Expression
1987 Science
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
2001
Association of adenovirus early-region 1A proteins with cellular polypeptides.
1986
Induction of cellular DNA synthesis by purified adenovirus E1A proteins
1986
A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.
1987
A retrovirus expressing the 12S adenoviral E1A gene product can immortalize epithelial cells from a broad range of rat tissues.
1988
Two regions of the adenovirus early region 1A proteins are required for transformation
1988
cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.
1991
Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
1987
Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.
1987
Toward a molecular definition of long-term memory storage
1996 StandoutNobel
A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.
1994
Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.
1987
Functional domains of adenovirus type 5 E1a proteins
1987
Adenovirus E1A Coding Sequences That Enable ras and pmt Oncogenes To Transform Cultured Primary Cells
1986
Biochemical and biological activity of the anthracycline analog, 4-demethyl-6-0-methyl-doxorubicin
1986
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.
2002
Influence of some chromophore substituents on the intercalation of anthracycline antibiotics into DNA
1982
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
2011 Science
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995
Works of Anna Velcich being referenced
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
2013 Science
Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation
2008
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
2002 Science
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
2008
Expression of Pla2g2a prevents carcinogenesis in Muc2‐deficient mice
2008
Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection
2010
Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation
2003
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
2006
Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
2010
Inactivation of p21 Enhances Intestinal Tumor Formation in Muc2−/− Mice
2005
The interaction of adriamycin and its β anomer with DNA
1977
Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions.
1988
Adenovirus E1a proteins repress transcription from the SV40 early promoter
1985
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
2001
Changes of activity of daunorubicin, adriamycin and stereoisomers following the introduction or removal of hydroxyl groups in the amino sugar moiety
1977
Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
2001
The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis
2013
Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans
1977
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
2008 Standout
Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.
2001
Steric influence of the orientation of the primary amino group at position 3 of the sugar moiety of anthracycline antibiotics in DNA binding properties
1977
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
2010
Functional analysis of an isolated fos promoter element with AP-1 site homology reveals cell type-specific transcriptional properties.
1990
Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells.
1989
Adenovirus E1a ras Cooperation Activity Is Separate from Its Positive and Negative Transcription Regulatory Functions
1988
Adenovirus E1a Proteins Repress Expression from Polyomavirus Early and Late Promoters
1986