Citation Impact
Citing Papers
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
2011 Standout
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
2016 StandoutScience
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
2012
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Mutations in NALP12 cause hereditary periodic fever syndromes
2008
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
2010
Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
2011
Reactive Oxygen Species in Inflammation and Tissue Injury
2013 Standout
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
2015 Standout
Why not treat human cancer with interleukin-1 blockade?
2010
Gout-associated uric acid crystals activate the NALP3 inflammasome
2006 StandoutNature
The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines
2013
Necroptosis and its role in inflammation
2015 StandoutNature
COPs and POPs Patrol Inflammasome Activation
2017
Autoinflammatory Disease Reloaded: A Clinical Perspective
2010 Standout
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Targeting inflammation in the treatment of type 2 diabetes: time to start
2014
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Metabolic Pathways in Immune Cell Activation and Quiescence
2013
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
2013
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes
2011
A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse
2013
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages
2018
Familial autoinflammatory diseases: genetics, pathogenesis and treatment
2005
Critical functions of priming and lysosomal damage for NLRP3 activation
2010
Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]
2013
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Targeting the NLRP3 inflammasome in inflammatory diseases
2018
The IL-1 family of cytokines and receptors in rheumatic diseases
2019
Mutations in cryopyrin: Bypassing roadblocks in the caspase 1 inflammasome for interleukin‐1β secretion and disease activity
2007
Inflammasome and IL-1β-Mediated Disorders
2010
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
2016
Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity
2018
Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders
2011
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice
1996 StandoutNobel
Mitochondria in the Regulation of Innate and Adaptive Immunity
2015
Schnitzler syndrome: Treatment failure to rituximab but response to anakinra
2007
The immunomodulating role of exercise in metabolic disease
2014
The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study
2014
A clinical review of 105 patients with PFAPA (a periodic fever syndrome)
2009
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Pyroptosis: host cell death and inflammation
2009 Standout
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
2015
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Blockade of interleukin 1 in type 1 diabetes mellitus
2010
The Inflammasomes
2010 Standout
Mechanisms and Functions of Inflammasomes
2014 Standout
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
2012 Nature
The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis
2008
COVID-19: consider cytokine storm syndromes and immunosuppression
2020 Standout
NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
2016
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2
2007 StandoutNobel
Efficacy and safety of rilonacept (interleukin‐1 trap) in patients with cryopyrin‐associated periodic syndromes: Results from two sequential placebo‐controlled studies
2008
The Hallmarks of Aging
2013 Standout
Physiological Roles of Mitochondrial Reactive Oxygen Species
2012 Standout
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome
2015
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
2013
Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome
2009
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
The inflammasomes: mechanisms of activation and function
2010
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
2015 Standout
Mevalonate pathway: A review of clinical and therapeutical implications
2007
Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis
2010
Human Monocytes Engage an Alternative Inflammasome Pathway
2016
Inflammasomes in health and disease
2012 StandoutNature
Autoinflammation: The prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses
2009
Genetic clues to understanding periodic fevers, and possible therapies
2002
IL‐1: Discoveries, controversies and future directions
2010
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion
2010
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
2014
Recent Advances in the Genetics of Autoimmune Disease
2008
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation
2012
Overview of the IL ‐1 family in innate inflammation and acquired immunity
2017
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
2014
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Signal transduction by reactive oxygen species
2011 Standout
Immunological and Inflammatory Functions of the Interleukin-1 Family
2009 Standout
B-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial Infarction
2003
Targeting Interleukin-1 in Heart Disease
2013
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
2013
Inflammasomes and Metabolic Disease
2013
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
2017
Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
2018
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
2020 Standout
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
2011
Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction
2015
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming
2018
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
2018 Standout
Inflammasomes and Their Roles in Health and Disease
2012
From C-Reactive Protein to Interleukin-6 to Interleukin-1
2016
Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease
2010
Discovery of a Viral NLR Homolog that Inhibits the Inflammasome
2011 Science
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
2009 Standout
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Differentiation of Effector CD4 T Cell Populations
2010 Standout
The NLRP3 Inflammasome as a Pharmacological Target
2019
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of Anna Simon being referenced
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
2011
Follow-up, clinical features, and quality of life in 10.3 patients with HyperImmunoglubulin D syndrome
2008
Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome
2001
Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome
2012
Hot and hobbling with hives: Schnitzler syndrome
2005
Hereditary periodic fever and reactive amyloidosis
2005
The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome
2015
Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome
2004
Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response
2004
IL-1β Processing in Host Defense: Beyond the Inflammasomes
2010
Familial periodic fever and amyloidosis due to a new mutation in the TNFRSF1A gene
2001
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
2012
Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes
2006
Long-Term Follow-Up, Clinical Features, and Quality of Life in a Series of 103 Patients With Hyperimmunoglobulinemia D Syndrome
2008
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
2009
Complete remission of severe idiopathic cold urticaria on interleukin-1 receptor antagonist (anakinra).
2009
Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model.
2005
Schnitzler Syndrome: Beyond the Case Reports: Review and Follow-Up of 94 Patients with an Emphasis on Prognosis and Treatment
2007
Molecular Analysis of the Mevalonate Kinase Gene in a Cohort of Patients with the Hyper-IgD and Periodic Fever Syndrome: Its Application as a Diagnostic Tool
2001
Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
2010
Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group.
1993
A Clinical Criterion to Exclude the Hyperimmunoglobulin D Syndrome (Mild Mevalonate Kinase Deficiency) in Patients with Recurrent Fever
2009