Citation Impact
Citing Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
Structural basis for the interaction of Ras with RaIGDS
1998
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
Structure of GATE-16, Membrane Transport Modulator and Mammalian Ortholog of Autophagocytosis Factor Aut7p
2000
A Primer on Vesicle Budding
1999 StandoutNobel
Structure of Cdc42 bound to the GTPase binding domain of PAK.
2000
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Structure of the TPR Domain of p67phox in Complex with Rac·GTP
2000
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK
1999 Nature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Evolution of the rab family of small GTP-binding proteins
2001
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
2000
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
1999 Standout
On the Role of Electrostatic Interactions in the Design of Protein–Protein Interfaces
2002
Why have mutagenesis studies not located the general base in ras p21
1994 StandoutNobel
The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1
1999
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
KSR, a novel protein kinase required for RAS signal transduction
1995
The effector interactions of p21ras
1993
Interactions between Ras proteins and their effectors
1996
Structure of the recA protein–ADP complex
1992 StandoutNatureNobel
Regulators and Effectors of ras Proteins
1991
The crystal structure of microtubule‐associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8
2004 StandoutNobel
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
1989 Nature
On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins
1992 StandoutNobel
Structural insights into the function of the Rab GDI superfamily
1996
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
1999 StandoutNatureNobel
Structure of GABARAP in Two Conformations
2002
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study
1994
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells
1999
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
1997 StandoutNatureNobel
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
Membrane Fusion
2003 StandoutNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
1997
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport
1999 Nature
Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the ras-family GTPase ran 1 1Edited by I. B. Holland
1998
Regulation of Membrane Trafficking
1999
Structural and Functional Analysis of the ARF1–ARFGAP Complex Reveals a Role for Coatomer in GTP Hydrolysis
1999
Molecular themes in oncogenesis
1991 StandoutNobel
Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue
1998
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion
2007 StandoutNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
The P-loop — a common motif in ATP- and GTP-binding proteins
1990 Standout
Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution
1999
The Conformation of Bound GMPPNP Suggests a Mechanism for Gating the Active Site of the SRP GTPase
2001
Ubiquitin and ubiquitin-like proteins as multifunctional signals
2005
Structural insights into phosphoinositide 3-kinase catalysis and signalling
1999 Nature
Signal transduction pathways involving RAS
1994
Why nature really chose phosphate
2013 StandoutNobel
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Structural and biochemical analysis of Ras‐effector signaling via RalGDS
1999
Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein
1999 Nature
The structure of the Q69L mutant of GDP-ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2) 1 1Edited by I. B. Holland
1998
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins
1995 StandoutNobel
The Differential Effects of the Gly-60 to Ala Mutation on the Interaction of H-Ras p21 with Different Downstream Targets
1996
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
1990
Small GTP-Binding Proteins
2001 Standout
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems
1993 Standout
Identification of Two GTP-Binding Proteins in the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
The GTP binding motif: variations on a theme
1996
Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code
1993 Science
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
1997 Science
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
2012
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
1992
Guanosine triphosphatase stimulation of oncogenic Ras mutants
1999
Induction of p130cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases
1996
Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant.
1991
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Visualizing tmRNA Entry into a Stalled Ribosome
2003 StandoutScienceNobel
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Regulation of the GTPase cycle of the neuronally expressed Ras-like GTP-binding protein Rab3A.
1993
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.
1996 StandoutNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
Crystal Structure of the Ternary Complex of Phe-tRNA Phe , EF-Tu, and a GTP Analog
1995 Science
A Detailed View of a Ribosomal Active Site
1999 StandoutNobel
Works of Anna Scherer being referenced
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
1995 Nature
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
1990
Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues
1989