Anna Pasternak

Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery

Delivery materials for siRNA therapeutics

The current state and future directions of RNAi-based therapeutics

Dynamic RNA Modifications in Gene Expression Regulation

Non-viral vectors for gene-based therapy

Aptamers as targeted therapeutics: current potential and challenges

Impact of 2′‐hydroxyl sampling on the conformational properties of RNA: Update of the CHARMM all‐atom additive force field for RNA

Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs

Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy

The application of DNA and RNA G-quadruplexes to therapeutic medicines

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

Modeling nucleic acids

Modeling and automation of sequencing-based characterization of RNA structure

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

Interplay of LNA and 2′-O-Methyl RNA in the Structure and Thermodynamics of RNA Hybrid Systems: A Molecular Dynamics Study Using the Revised AMBER Force Field and Comparison with Experimental Results

Silencing or Stimulation? siRNA Delivery and the Immune System

Artificial Molecular Machines

Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the Bacillus subtilis RNase P RNA Specificity Domain

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

Contributions of Stacking, Preorganization, and Hydrogen Bonding to the Thermodynamic Stability of Duplexes between RNA and 2′- O -Methyl RNA with Locked Nucleic Acids

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

A chemical synthesis of LNA-2,6-diaminopurine riboside, and the influence of 2′-O-methyl-2,6-diaminopurine and LNA-2,6-diaminopurine ribosides on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2′-C-piperazino-UNA monomer

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

The Thermodynamics of 3‘-Terminal Pyrene and Guanosine for the Design of Isoenergetic 2‘-O-Methyl-RNA-LNA Chimeric Oligonucleotide Probes of RNA Structure