Citation Impact
Citing Papers
2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
2018 Standout
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
2006 Standout
Structural and functional evolution of the P2Y12-like receptor group
2007
Homocysteine and vascular disease
1999 Standout
Advances in signalling by extracellular nucleotides
2000
Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients
2015 StandoutNobel
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis
2003
Platelet Aggregation and Recruitment with Aspirin-Clopidogrel Therapy
2008
Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists
2009
Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
2017 StandoutNobel
Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases
2008 StandoutNobel
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist
2001
Involvement of P2 receptors in the growth and survival of neurons in the CNS
2005
Identification, Characterization, and Inhibition of the Platelet ADP Receptors
2001
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention
2011 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Akt Activation in Platelets Depends on Gi Signaling Pathways
2004
Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
2014 Standout
Adenine triphosphate nucleotides are antagonists at the P2Y12 receptor
2004
Molecular Basis for ADP-induced Platelet Activation
1998
Transfusion Medicine — Blood Transfusion
1999 Standout
PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation
2006
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
The central role of the P2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity
2000
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
2005
The P2Y1 receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel
1998
Pathophysiology and Therapeutic Potential of Purinergic Signaling
2006
Antithrombotic Therapy for VTE Disease
2012 Standout
Role of Prasugrel, a Novel P2Y12 Receptor Antagonist, in the Management of Acute Coronary Syndromes
2009
Platelet Activation and Atherothrombosis
2007 Standout
Effects of inhibition of P2Y1 and P2Y12 on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry
2003 StandoutNobel
Fluorescent and colorimetric probes for detection of thiols
2010 Standout
Determinants of the interindividual variability in response to antiplatelet drugs
2005
Antiplatelet Drugs
2008
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
2004
Treatment of von Willebrand's Disease
2004
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial
2004 Standout
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor–null mice
1999
Pharmacological control of platelet function
2001
Indobufen versus Placebo in the Prevention of Restenosis after Carotid Endarterectomy: A Double-Blind Pilot Study
1991
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
REVIEWLaboratory investigation of platelet function
1999
Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
2016 StandoutNobel
Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y1 receptor antagonists
2004
P2T Purinoceptors: ADP Receptors on Platelets
2007
Antiplatelet action of R‐99224, an active metabolite of a novel thienopyridine‐type Gi‐linked P2T antagonist, CS‐747
2001
Platelets in inflammation and atherogenesis
2005 Standout
Prevention of Venous Thromboembolism
2004 Standout
An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.
1995
The immunology of stroke: from mechanisms to translation
2011 Standout
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor
1996 Standout
Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.
1989
PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis
2007
Coordinated Signaling through Both G12/13 and Gi Pathways Is Sufficient to Activate GPIIb/IIIa in Human Platelets
2002
The birth and postnatal development of purinergic signalling
2010
The creation of an antithrombotic surface by apyrase immobilization
2010 StandoutNobel
Receptors for ADP on human blood platelets
1994
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
2001
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
2006 StandoutNobel
P2X1 Purinoceptor in Human Platelets
1998
Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP‐ and thrombin‐induced human platelet activation
2004 StandoutNobel
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
2001 Standout
Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-α Secretion and Signaling through a Nucleotide Receptor
2002 StandoutNobel
The red cell transfusion trigger: has a sin of commission now become a sin of omission?
1998
G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions
2012
P2Y1‐receptors in human platelets which are pharmacologically distinct from P2YADP‐receptors
1998
Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage
2015
Prophylaxis of Recurrent Deep Venous Thrombosis. A Randomized, Prospective Study Using Indobufen and Graduated Elastic Compression Stockings
1993
Ticagrelor: a P2Y12antagonist for use in acute coronary syndromes
2012
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation
2003 StandoutNobel
Signaling through Gi Family Members in Platelets
2002
Thrombosis of the Cerebral Veins and Sinuses
2005 Standout
Molecular Basis for ADP-induced Platelet Activation
1998
Platelet-Active Drugs
2001
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
2005
Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects
2004
P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
2003
Central role of the P2Y12 receptor in platelet activation
2004
Development of Selective High Affinity Antagonists, Agonists, and Radioligands for the P2Y1 Receptor
2008
Nucleotide receptors: an emerging family of regulatory molecules in blood cells
2001
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
2006 Standout
Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets
2011 StandoutNobel
ADP can induce aggregation of human platelets via both P2Y1 and P2T receptors
2000
Hyperhomocysteinemia, Atherosclerosis and Thrombosis
1999
P2Y1 Antagonists: Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring
2007
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Open Multicentre Study of the P 2T Receptor Antagonist AR-C69931MX Assessing Safety, Tolerability and Activity in Patients with Acute Coronary Syndromes
2001
ADP Receptors of Platelets and their Inhibition
2001
Key Role of the P2Y1Receptor in Tissue Factor–Induced Thrombin-Dependent Acute Thromboembolism
2001
Molecular Physiology of P2X Receptors
2002 Standout
Simultaneous determination of methionine and total homocysteine in human plasma by gas chromatography–mass spectrometry
2001
Effects of antiplatelet therapy with indobufen or aspirin-dipyridamole on graft patency one year after coronary artery bypass grafting
1994
Evidence for Two Distinct G-protein-coupled ADP Receptors Mediating Platelet Activation
1999
Indobufen Versus Warfarin in the Secondary Prevention of Major Vascular Events in Nonrheumatic Atrial Fibrillation
1997
Effects of nucleotides and nucleosides on coagulation
2010
Acyclic Analogues of Adenosine Bisphosphates as P2Y Receptor Antagonists: Phosphate Substitution Leads to Multiple Pathways of Inhibition of Platelet Aggregation
2002
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
Overview of P2 receptors: Possible functions in immune cells
2001
Ultrastructural Studies of Platelet Aggregates From Human Subjects Receiving Clopidogrel and From a Patient With an Inherited Defect of an ADP-Dependent Pathway of Platelet Activation
1996
Contemporary platelet function testing
2010
Platelets and Cardiovascular Disease
2002
Novel structurally altered P2X1 receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells
2001
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
2006 Standout
Potentiation of Thromboxane A2-induced Platelet Secretion by Gi Signaling through the Phosphoinositide-3 Kinase Pathway
2001
Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation
2007 Standout
The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects
2010
Alternative Activation of Macrophages: An Immunologic Functional Perspective
2008 Standout
Synthesis and Structure−Activity Relationships of Uracil Nucleotide Derivatives and Analogues as Agonists at Human P2Y2, P2Y4, and P2Y6Receptors
2006
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
2002 StandoutScience
Hyperhomocysteinemia, Low Folate and Vitamin B 12 Concentrations, and Methylene Tetrahydrofolate Reductase Mutation in Cerebral Venous Thrombosis
2004
New P2Y 12 Inhibitors
2010
A NOVEL SYNTHESIS OF THIENOPYRIDINE, PYRROLOQUINOLINOTHIOPHENE, PYRAZOLOPYRIDIN-3-YL-PHENYLTHIOUREA AND THIAZOLYLPYRAZOLOPYRIDINE DERIVATIVES
1999
Superiority of Clopidogrel Versus Aspirin in Patients With Prior Cardiac Surgery
2001
Aortocoronary Saphenous Vein Graft Disease
1998 Standout
Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study
2009
Architecture of P2Y Nucleotide Receptors: Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling
2004
2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
2015 Standout
The human platelet ADP receptor activates Gi2 proteins
1995
Receptors for Purines and Pyrimidines
2012 Standout
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
2014 Standout
Thioamides as Useful Synthons in the Synthesis of Heterocycles
2002 Standout
Activation of Platelet Function Through G Protein–Coupled Receptors
2006
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
2013 Standout
ADP Receptors and Clinical Bleeding Disorders
1999
Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis
2007
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
2014 Standout
Ticagrelor Compared With Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial
2011
P2 receptor subtypes in the cardiovascular system
1998
Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
1998
ADP Receptors on Platelets
1996
Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response
2004
Physiology of Microglia
2011 Standout
Works of Anna Lecchi being referenced
Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors
1995
In vitro and ex vivo Effects of Indobufen on Human Platelet Aggregation, the Release Reaction and Thromboxane B2 Production
1987
Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor
2004
Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count
2007
Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin
2007
Plasma homocysteine levels in 10 patients with polycythemia.
1997
Ticlopidine Selectively Inhibits Human Platelet Responses to Adenosine Diphosphate
1991
Evaluation of the PFA-100® System in the Diagnosis and Therapeutic Monitoring of Patients with von Willebrand Disease
1999
Molecular bases of defective signal transduction in the platelet P2Y 12 receptor of a patient with congenital bleeding
2003
Platelet aggregation at high shear is impaired in patients with congenital defects of platelet secretion and is corrected by DDAVP: correlation with the bleeding time.
1995
Is the Oral Methionine Loading Test Insensitive to the Remethylation Pathway of Homocysteine?
1999
Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
1992
CHARACTERIZATION OF PLATELETS OF A PATIENT WITH A SELECTIVE DEFECT IN ADP-INDUCED AGGREGATION
1987
Is the Oral Methionine Loading Test Insensitive to the Remethylation Pathway of Homocysteine?
1999
Shear-induced platelet aggregation is potentiated by desmopressin and inhibited by ticlopidine.
1993
Fibrinogen-independent aggregation and deaggregation of human platelets: studies in two afibrinogenemic patients
1987
Platelets From a Patient Heterozygous for the Defect of P2 CYC Receptors for ADP Have a Secretion Defect Despite Normal Thromboxane A 2 Production and Normal Granule Stores
2000
Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates
1990
Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
1992
Effects of 5‘-Phosphate Derivatives of 2-Hexynyl Adenosine and 2-Phenylethynyl Adenosine on Responses of Human Platelets Mediated by P2Y Receptors
2005
Low Plasma Levels of Vitamin B 6 Are Independently Associated With a Heightened Risk of Deep-Vein Thrombosis
2001
Protease-activated receptors 1 and 4 do not stimulate Gi signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of Gisignaling
2002
The P2Y1 Receptor Is Normal in a Patient Presenting a Severe Deficiency of ADP-induced Platelet Aggregation
1999