Citation Impact
Citing Papers
Cellular Restriction Targeting Viral Capsids Perturbs Human Immunodeficiency Virus Type 1 Infection of Nondividing Cells
2009
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
2005 StandoutNobel
Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice
2019
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
2007
Functional diversity of helper T lymphocytes
1996 StandoutNature
Engineering precision nanoparticles for drug delivery
2020 Standout
Nuclear landscape of HIV-1 infection and integration
2016
Inflammation and cancer
2002 StandoutNature
Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
2022
The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
1997
Oncogenic kinase signalling
2001 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
2011
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
1999
Prediction of the sequence-specific cleavage activity of Cas9 variants
2020
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
Hallmarks of aging: An expanding universe
2023 Standout
NmeCas9 is an intrinsically high-fidelity genome-editing platform
2018
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
STAT3 is constitutively active in some patients with Polycythemia rubra vera
2001
STAT family of transcription factors in cytokine-mediated biological responses
2000
Stat3 as an Oncogene
1999 Standout
Proteasome- and p53-dependent Masking of Signal Transducer and Activator of Transcription (STAT) Factors
1997 StandoutNobel
Epstein–Barr virus-derived EBNA2 regulates STAT3 activation
2008
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
1998
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
2018
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
1997
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
1999 StandoutNobel
Virus-mediated gene delivery for human gene therapy
2012
JAK/STAT signaling by cytokine receptors
1998
The role of constitutively active Stat6 in leukemia and lymphoma
2005
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
2000
Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
1999
A family of cytokine-inducible inhibitors of signalling
1997 StandoutNature
The role of STATs in transcriptional control and their impact on cellular function
2000
The JAK-STAT Pathway: Signal Transduction Involved in Proliferation, Differentiation and Transformation
1998
Genome editing by natural and engineered CRISPR-associated nucleases
2018
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis
1996 Standout
Highly Parallel Profiling of Cas9 Variant Specificity
2020
STATs in oncogenesis
2000 Standout
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Immunity, Inflammation, and Cancer
2010 Standout
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
1998
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
2003 Standout
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
1999
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
1995
Nuclear import by karyopherin-βs: Recognition and inhibition
2010
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis
2002
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
2020 StandoutNobel
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Genome-wide profiling of adenine base editor specificity by EndoV-seq
2019
TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm
2013
Increasing the specificity of CRISPR systems with engineered RNA secondary structures
2019
STAT signaling in the pathogenesis and treatment of leukemias
2000
The next generation of CRISPR–Cas technologies and applications
2019
Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2
2000
STAT proteins as novel targets for cancer therapy
1999
STATs and cytokine specificity
1996
Cytosolic Tyrosine Dephosphorylation of STAT5
2000
Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG
2019
AKT/PKB Signaling: Navigating the Network
2017 Standout
Activation of STAT proteins and growth control
2001
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Constitutive Activation of JAK1 in Src-transformed Cells
1997
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
Knockdown Screens to Knockout HIV-1
2008
Points of control in inflammation
2002 StandoutNature
Directed evolution of CRISPR-Cas9 to increase its specificity
2018
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation
2001
Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome
2002
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
1998
Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
1998
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing
2018
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders
2005 Standout
Cytokine receptor signalling
1995 Nature
The Jak-STAT pathway
2000
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Distinct Tumorigenic Potential of abl and raf in B Cell Neoplasia: abl Activates the IL-6 Signaling Pathway
1996
High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells
2020
The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells
1999
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
Activation of Signal Transducers and Activators of Transcription 3 and Focal Adhesion Kinase by Stromal Cell-Derived Factor 1 Is Required for Migration of Human Mesenchymal Stem Cells in Response to Tumor Cell-Conditioned Medium
2009
The molecular basis of IL-21–mediated proliferation
2007
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
1999
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
2000
STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation
1997
Stat3 Activation Is Required for Cellular Transformation by v-src
1998
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
1996
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
STATs and Gene Regulation
1997 StandoutScience
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
1999
Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
1996
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals
1997
JAKS AND STATS: Biological Implications
1998 Standout
Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
2000 StandoutScience
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
1998 StandoutScience
Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation
1998
Interleukin 15: biology and relevance to human disease
2001
Constitutive activation ofStat5aby retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
2002
Cloning of Human Stat5B
1996
Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.
1996
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
2002 StandoutNobel
STAT Signaling in the Pathogenesis and Treatment of Cancer
1999
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
1996
A New Class of Medicines through DNA Editing
2019
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
1999
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
1998
Jak-STAT Signaling Induced by the v- abl oncogene
1995 Science
Functional Differences between Stat3α and Stat3β
1997 Nobel
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
1998
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
1997
Specific Inhibition of Stat3 Signal Transduction by PIAS3
1997 StandoutScience
Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1
1996
THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling
1996
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
1997
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
1996
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines
1996
Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute Protection Against Myocardial Ischemia/Reperfusion Injury
2004 StandoutNobel
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
1996
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.
1996
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck
1997
mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 Adipocytes
2010
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
1996
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells
1997
Works of Anna Cereseto being referenced
Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
2017
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
2021
Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes
2010
HIV-1 Pre-Integration Complexes Selectively Target Decondensed Chromatin in the Nuclear Periphery
2008
Acetylation of HIV‐1 integrase by p300 regulates viral integration
2005
A highly specific SpCas9 variant is identified by in vivo screening in yeast
2018
Transportin-SR2 Imports HIV into the Nucleus
2008
The TRIM Family Protein KAP1 Inhibits HIV-1 Integration
2011
GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
2010
Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing
2019
Cytokine response gene 6 induces p21 and regulates both cell growth and arrest
1999
Integration site selection by retroviruses.
2004
Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.
1995
Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I
1995 Science
Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain
1998
Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions
2016
Acetylation of Conserved Lysines in the Catalytic Core of Cyclin-Dependent Kinase 9 Inhibits Kinase Activity and Regulates Transcription
2008
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
1997