Citation Impact
Citing Papers
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
2006
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
2014 Science
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
2012
The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
2007
Defining the Epithelial Stem Cell Niche in Skin
2003 StandoutScience
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
2005 Science
Subtypes of Breast Cancer Show Preferential Site of Relapse
2008
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
2008
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
2009 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
2000
Wnt Activates the Tak1/Nemo-like Kinase Pathway
2004
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
1999
Caught up in a Wnt storm: Wnt signaling in cancer
2003
mTOR Signaling in Growth Control and Disease
2012 Standout
Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling
2000
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism
2000
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
2012 Nature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
2004
Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Results from a European Cooperative Study1
2000
Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism
2008
HDAC6 is a microtubule-associated deacetylase
2002 StandoutNature
Surviving at a Distance: Organ-Specific Metastasis
2015
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Unravelling the complexity of metastasis — molecular understanding and targeted therapies
2011
Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
2013
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization
2003
Alleles of the APC gene: An attenuated form of familial polyposis
1993
Wnt proteins are lipid-modified and can act as stem cell growth factors
2003 StandoutNature
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture
2010
Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation
2014
A Mechanism for Wnt Coreceptor Activation
2004
Lessons from Hereditary Colorectal Cancer
1996 Standout
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
The Epigenomics of Cancer
2007 Standout
Wnt signaling in the intestinal epithelium: from endoderm to cancer
2005
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
2005
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways
2007
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
2001
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
2011
WNT Signals Are Required for the Initiation of Hair Follicle Development
2002 Standout
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
2002
Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
2010
Ligand Receptor Interactions in the Wnt Signaling Pathway inDrosophila
2002
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling
2008
Gp38k, a Protein Synthesized by Vascular Smooth Muscle Cells, Stimulates Directional Migration of Human Umbilical Vein Endothelial Cells
1999
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
2015
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
2003
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
2006
Emerging Biological Principles of Metastasis
2017 Standout
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
2002 Nature
The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity
2005
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
1999
Mutations of theAPC adenomatous polyposis coli) gene
1993
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
2006
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
2011
Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q
2004
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Expression Pattern of Wnt Signaling Components in the Adult Intestine
2005
WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
2009
Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein
2005
Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients
1993
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Parathyroid hormone signaling through low-density lipoprotein-related protein 6
2008
Mechanisms of Bone Metastasis
2004 Standout
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6
2010
Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins
2005
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
2012 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
2009
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
2003
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Dickkopf-1 is a master regulator of joint remodeling
2007
R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling
2007
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction
2005 Nature
Modeling Development and Disease with Organoids
2016 Standout
Inflammatory bone loss: pathogenesis and therapeutic intervention
2012 Standout
Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes
2007
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
1996
Alternative Wnt Signaling Is Initiated by Distinct Receptors
2008
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.
1996
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines
2006
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
2009
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
2008
Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation
2008
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
2005
Targeting the bone marrow microenvironment in multiple myeloma
2014
Wnt signaling and cancer
2000 Standout
Inhibition of Adipogenesis by Wnt Signaling
2000 StandoutScience
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
2006
Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
2007 StandoutScience
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
Towards an integrated view of Wnt signaling in development
2009
Wnt proteins synergize to activate β-catenin signaling
2017
SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease
2010
Direct pKa Measurement of the Active-Site Cytosine in a Genomic Hepatitis Delta Virus Ribozyme
2001 StandoutNobel
Glycogen Synthase Kinase 3 Is an Insulin-Regulated C/EBPα Kinase
1999
Metabolic reprogramming and cancer progression
2020 StandoutScience
Soluble Frizzled-Related Protein 1 Is Estrogen Inducible in Bone Marrow Stromal Cells and Suppresses the Earliest Events in Lymphopoiesis
2008
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 StandoutScience
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
2003
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
2013 StandoutScience
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
1996
Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
2002
Works of Anna Bafico being referenced
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts
2005
Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling
1999
Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma
2009
Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling
1999
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
2004
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
2001
The Human Frizzled 6 (HFz6) Acts as a Negative Regulator of the Canonical Wnt·β-Catenin Signaling Cascade
2004
Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
1999
Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts
1998
The Wnt Receptor, Lrp5, Is Expressed by Mouse Mammary Stem Cells and Is Required to Maintain the Basal Lineage
2009
Mutation in a splice-donor site of the APC gene in a family with polyposis and late age of colonic cancer death
1994
Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations
1994
Differential Effects Of Hepatocyte Growth Factor Isoforms On Epithelial And Endothelial Tubulogenesis
1998
Prostate Cancer Cells Promote Osteoblastic Bone Metastases through Wnts
2005
A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor
2003
Analysis of Endogenous LRP6 Function Reveals a Novel Feedback Mechanism by Which Wnt Negatively Regulates Its Receptor
2007
Characterization of 19 novel and six recurring APC mutations in Italian adenomatous polyposis patients, using two different mutation detection techniques
1997
Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.
1993