Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival
1999
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression
1998
Bim is a suppressor of Myc-induced mouse B cell leukemia
2004
Functional diversity of helper T lymphocytes
1996 StandoutNature
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
The TIM gene family: emerging roles in immunity and disease
2003
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
1997 Nobel
IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
1996
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
2006 StandoutNature
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
2012
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
2007
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
The DNA double-strand break response in the nervous system
2004
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Network biology: understanding the cell's functional organization
2004 Standout
Drosophila Bcl‐2 proteins participate in stress‐induced apoptosis, but are not required for normal development
2007
Molecular and cellular regulation of human glucokinase
2019
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
1995
CD4+ T-cell subsets in autoimmunity
1997
Regulatory T Cells
2000 StandoutNobel
Effect of interleukin‐10 on dendritic cell maturation and function
1997
The lineage decisions of helper T cells
2002
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
1995
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk
2004
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis
2000
Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis
2004
Pharmacological manipulation of Bcl-2 family members to control cell death
2005
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
2005
Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
1995
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
2006
Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis
2004
Comparison of CD28‐B7.1 and B7.2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production
1996
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
2005
Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
2004
Cell Death
2004 Standout
Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
1998
The Interaction Properties of Costimulatory Molecules Revisited
2002
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
2005
Deletion of a coordinate regulator of type 2 cytokine expression in mice
2001
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
2000
Bax-dependent Regulation of Bak by Voltage-dependent Anion Channel 2
2005
PI3K/Akt and apoptosis: size matters
2003
An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
1995
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation
2004
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
Autophagy in metazoans: cell survival in the land of plenty
2005
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
2003
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
2005
A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells
2002
Mechanisms underlying T-cell tolerance
1996
Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis
2005
Dendritic cell regulation of TH1-TH2 development
2000
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
Dendritic Cells
1999
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
1996 Nature
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Inactivating mutations of proapoptotic Bad gene in human colon cancers
2004
Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo
2000
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4
1998
Caspase-dependent Cleavage of Signaling Proteins during Apoptosis
1998
Mitochondrial dysfunction as a cause of optic neuropathies
2004
Autophagy: dual roles in life and death?
2005
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
2003 Nature
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
Delving deeper: MCL-1's contributions to normal and cancer biology
2012
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
2001
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
2002 StandoutNature
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
2012
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim
2001
Points of control in inflammation
2002 StandoutNature
The role of BH3-only proteins in the immune system
2005
Life in the balance: how BH3-only proteins induce apoptosis
2005
A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells
1997
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
2006
The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond
1996
T lymphocyte differentiation in the periphery
1998
Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis
2006
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses
1998
AKAP signalling complexes: focal points in space and time
2004
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
2006
New perspectives of C1328-137-mediated T cell costimulation
1995
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
B7 Costimulation in the Development of Lupus: Autoimmunity Arises Either in the Absence of B7.1/B7.2 or in the Presence of Anti-B7.1/B7.2 Blocking Antibodies
1999
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
1999
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.
1996
Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 Is Associated with Inhibition of Antigen-Induced Airway Hyperresponsiveness, Eosinophilia, and Serum IgE Levels
1998
The Pathophysiology of Mitochondrial Cell Death
2004 StandoutScience
Blockade of Epidermal Growth Factor Receptors Chemosensitizes Breast Cancer Cells through Up-Regulation of Bnip3L
2005
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
PAG-3, a Zn-finger transcription factor, determines neuroblast fate inC. elegans
2002 StandoutNobel
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity
1998
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002
Endonuclease G is required for early embryogenesis and normal apoptosis in mice
2003
Manipulation of costimulatory signals to enhance antitumor T-cell responses
1995 StandoutNobel
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
1997
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
1995
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells
1997
Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays
2004
Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.
1996
CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis
1999 Nobel
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade
2000
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
2004
(−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer
2005
A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation
2002 Science
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Conditional stability of T cells
2010 StandoutNatureNobel
Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
2003
Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
2006
Late Complications of Immune Deviation Therapy in a Nonhuman Primate
1996 Science
Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis
1999
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses
2005
Immunobiology of Dendritic Cells
2000 Standout
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
1995
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
The Instructive Role of Innate Immunity in the Acquired Immune Response
1996 Science
Blockade of Costimulation Through B7/CD28 Inhibits Experimental Autoimmune Uveoretinitis, But Does Not Induce Long-Term Tolerance
2000
B7.2 Has Opposing Roles During the Activation Versus Effector Stages of Experimental Autoimmune Thyroiditis
1999
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels.
1998
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Newcomers in the process of mitochondrial permeabilization
2005
Defective T Cell Differentiation in the Absence of Jnk1
1998 Science
Spatial and temporal changes in Bax subcellular localization during anoikis
2003
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
2007
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjögren’s syndrome (SS) through up-regulated Th2 response
2000
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad.
2003
Mitotic spindle checkpoint inactivation by trichostatin A defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents
2005
Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers
1999
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
2009
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
2003 Nature
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
2004 StandoutScience
Works of Ann Ranger being referenced
Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis
2002
Mouse models of cell death
2001
NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation
2001
Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development
1998
Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice
1996
The transcription factor NF-ATc is essential for cardiac valve formation
1998 Nature
B7–2 (CD86) is essential for the development of IL-4-producing T cells
1996
Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc
1998
BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function
2004
Activation of BAD by Therapeutic Inhibition of Epidermal Growth Factor Receptor and Transactivation by Insulin-like Growth Factor Receptor
2002
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
1995
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
2003 Nature
Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
1997
Bad -deficient mice develop diffuse large B cell lymphoma
2003