Citation Impact
Citing Papers
Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
2001 StandoutScience
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
1999
Activation of UBC5 Ubiquitin-conjugating Enzyme by the RING Finger of ROC1 and Assembly of Active Ubiquitin Ligases by All Cullins
2002
NEDD8 recruits E2-ubiquitin to SCF E3 ligase
2001
Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase
2002
Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases
2004
SCFβ-TRCP and phosphorylation dependent ubiquitination of IκBα catalyzed by Ubc3 and Ubc4
2000
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105
2002 StandoutNobel
Crystal structure of the human COP9 signalosome
2014 Nature
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
Identification of a family of human F-box proteins
1999
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
2007 Nature
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
1999
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
2001
LIN-23-Mediated Degradation of β-Catenin Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
2005
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
A protein knockdown strategy to study the function of β-catenin in tumorigenesis
2003
The von Hippel–Lindau Tumor Suppressor Gene
2001 StandoutNobel
RNA Polymerase II Blockage by Cisplatin-damaged DNA
2005
Release of Ubiquitin-Charged Cdc34-S∼Ub from the RING Domain Is Essential for Ubiquitination of the SCFCdc4-Bound Substrate Sic1
2003
Triggering ubiquitination of a CDK inhibitor at origins of DNA replication
2001
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
2008
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
2001
Stability of Homologue of Slimb F-box Protein Is Regulated by Availability of Its Substrate
2004
Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor
2000
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
2000
Function and regulation of cullin–RING ubiquitin ligases
2005 Standout
Dual mode of degradation of Cdc25 A phosphatase
2002
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase
2004
The von Hippel–Lindau tumor suppressor protein
2001 StandoutNobel
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
2000
Neddylation and Deneddylation of CUL-3 Is Required to Target MEI-1/Katanin for Degradation at the Meiosis-to-Mitosis Transition in C. elegans
2003
Pseudosubstrate regulation of the SCF β-TrCP ubiquitin ligase by hnRNP-U
2002
Identification and Characterization of DEN1, a Deneddylase of the ULP Family
2003
The IKK NF-κB system: a treasure trove for drug development
2004
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
2002 Nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
NF-κB and the innate immune response
2000
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
2002
The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity
2006
TIP120A Associates with Cullins and Modulates Ubiquitin Ligase Activity
2003
Proteolysis and the cell cycle: with this RING I do thee destroy
2000
Global Identification of Modular Cullin-RING Ligase Substrates
2011
Homodimer of Two F-box Proteins βTrCP1 or βTrCP2 Binds to IκBα for Signal-dependent Ubiquitination
2000
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
2007
Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo
2003
NEDD8 Modification of CUL1 Dissociates p120CAND1, an Inhibitor of CUL1-SKP1 Binding and SCF Ligases
2002
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Ubiquitin: structures, functions, mechanisms
2004
Context of Multiubiquitin Chain Attachment Influences the Rate of Sic1 Degradation
2003
The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin
2003
SCFhFBH1 can act as helicase and E3 ubiquitin ligase
2004
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
The ABC of APC
2001
Themes and variations on ubiquitylation
2001
Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system
2000 StandoutNobel
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation
2008
The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation
2001
A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7
2004
Control of β-Catenin Stability
2000
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1
2003
Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
2001
Mechanism of Lysine 48-Linked Ubiquitin-Chain Synthesis by the Cullin-RING Ubiquitin-Ligase Complex SCF-Cdc34
2005
The RAG1 N-terminal domain is an E3 ubiquitin ligase
2003
The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain
1999
The Yeast Hex3·Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation
2007
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
2001 StandoutNobel
Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair
2003
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
2000
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Biophysical Studies of eIF4E Cap-binding Protein: Recognition of mRNA 5′ Cap Structure and Synthetic Fragments of eIF4G and 4E-BP1 Proteins
2002
Mammalian COP9 signalosome
2009
Signaling to NF-κB
2004 Standout
Common Pathway for the Ubiquitination of IκBα, IκBβ, and IκBε Mediated by the F-Box Protein FWD1
1999
COP9 Signalosome
2003
Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase
2003 StandoutNobel
A CDK-Independent Function of Mammalian Cks1
2001
Phosphorylation of the Human Ubiquitin-conjugating Enzyme, CDC34, by Casein Kinase 2
2001
CAND1 Binds to Unneddylated CUL1 and Regulates the Formation of SCF Ubiquitin E3 Ligase Complex
2002
Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p
2003
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
1999
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly
2001
ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity
1999
Phosphoserine/threonine-binding domains
2001
Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages
2007
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts
2000
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
2008
COP9 signalosome revisited: a novel mediator of protein degradation
2001
CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with β-TrCP and enhances β-catenin degradation
2002
Modes of regulation of ubiquitin-mediated protein degradation
2000 StandoutNobel
An intact NEDD8 pathway is required for Cullin‐dependent ubiquitylation in mammalian cells
2002 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response
2001 Science
The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase
1999 Science
BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage
2004
Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins
2003
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
2000
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Control of biochemical reactions through supramolecular RING domain self-assembly
2002
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
2001 Science
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Modification of Cullin-1 by Ubiquitin-like Protein Nedd8 Enhances the Activity of SCFskp2 toward p27kip1
2000
The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
2001
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans
2020
MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge
2009
ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase
2001
How the Cyclin Became a Cyclin
1999
The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination
2000
Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα
2000
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
2000
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
1999
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Mechanisms Underlying Ubiquitination
2001 Standout
RING Domain E3 Ubiquitin Ligases
2009 Standout
Exploring the functional complexity of cellular proteins by protein knockout
2003
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
2000
Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases.
2001
A comprehensive method for detecting ubiquitinated substrates using TR-TUBE
2015
The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1
2000
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
The Zinc Finger Domain of NEMO Is Selectively Required for NF-κB Activation by UV Radiation and Topoisomerase Inhibitors
2002
CUL7: A DOC domain-containing cullin selectively binds Skp1⋅Fbx29 to form an SCF-like complex
2002
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
2003
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
2001 Standout
The COP9 Signalosome
2003
Cell Cycle-Dependent Expression of Mammalian E2-C Regulated by the Anaphase-Promoting Complex/Cyclosome
2000
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
2009
Arabidopsis CAND1, an Unmodified CUL1-Interacting Protein, Is Involved in Multiple Developmental Pathways Controlled by Ubiquitin/Proteasome-Mediated Protein Degradation
2004
Whose end is destruction: cell division and the anaphase-promoting complex
1999
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
2007 StandoutScienceNobel
Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β- TrCP1 gene
2003
Works of Angus Chen being referenced
DEN1 Is a Dual Function Protease Capable of Processing the C Terminus of Nedd8 and Deconjugating Hyper-neddylated CUL1
2003
Conjugation of Nedd8 to CUL1 Enhances the Ability of the ROC1-CUL1 Complex to Promote Ubiquitin Polymerization
2000
Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα
1999
The Conserved RING-H2 Finger of ROC1 Is Required for Ubiquitin Ligation
2000
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin
1999
The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34
2002
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E 1 1Edited by D. Draper
2001
Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase
2002
The SCFHOS/β-TRCP-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation
2000