Standout Papers
Citation Impact
Citing Papers
Shear-induced unfolding triggers adhesion of von Willebrand factor fibers
2007 Standout
Size regulation of von Willebrand factor–mediated platelet thrombi by ADAMTS13 in flowing blood
2005
Molecular evolution of the nuclear von Willebrand factor gene in mammals and the phylogeny of rodents
1999
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Shear stress enhances the proteolysis of von Willebrand factor in normal plasma
1994
A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII
2009
Crystal structure of the LMAN1‐CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII
2010
Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin
1997
Biological functions of fucose in mammals
2017
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
1998 Standout
DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection
2007
The Axonally Secreted Serine Proteinase Inhibitor, Neuroserpin, Inhibits Plasminogen Activators and Plasmin but Not Thrombin
1998
Nucleotide signalling during inflammation
2014 StandoutNature
Von Willebrand factor, platelets and endothelial cell interactions
2003
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
2002
Wound repair and regeneration
2008 StandoutNature
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1
1995
Hallmarks of aging: An expanding universe
2023 Standout
The neurofibromatosis type 1 gene encodes a protein related to GAP
1990 Standout
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
Kinetic Characterization of the Proteinase Binding Defect in a Reactive Site Variant of the Serpin, Antithrombin
1995
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
2005 Standout
Solution Structure of Human von Willebrand Factor Studied Using Small Angle Neutron Scattering
2006
Tumor suppressor genes
1991 Standout
Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability
1994
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Platelets in atherothrombosis
2002
The Fibrinolytic System of the Vessel Wall and Its Role in the Control of Thrombosis
1990
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex
2003
Human and mouse proteases: a comparative genomic approach
2003
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Platelet Activation and Atherothrombosis
2007 Standout
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7.
1989
Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies
2000
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Low nucleotide diversity in man.
1991
Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators
2005
Crystal Structure of the Complex of Plasminogen Activator Inhibitor 2 with a Peptide Mimicking the Reactive Center Loop
2001
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
1988
Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor
2005
Reactive site mutants of recombinant protein C inhibitor
1995
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Expression of Factor VIII by Murine Liver Sinusoidal Endothelial Cells
1999
The genetical archaeology of the human genome
1996 StandoutNobel
Comparison of Human Chromosome 6p25 with Mouse Chromosome 13 Reveals a Greatly Expanded Ov-Serpin Gene Repertoire in the Mouse
2002
Target activation by regulatory RNAs in bacteria
2015
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Molecular themes in oncogenesis
1991 StandoutNobel
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
1993 Standout
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Uncovering the mysteries of invasive streptococcal diseases
2005
Differential growth state‐dependent regulation of plasminogen activator inhibitor type‐1 expression in senescent IMR‐90 human diploid fibroblasts
1995
The Contribution of Arginine Residues within the P6–P1 Region of α1-Antitrypsin to Its Reaction with Furin
2001
Complement
2001 Standout
Inactivation of Plasminogen Activator Inhibitor-1 by Specific Proteolysis with Stromelysin-1 (MMP-3)
2000
Disruption of the Sec24d Gene Results in Early Embryonic Lethality in the Mouse
2013
Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo
1988
Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition
2022
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Kinetics of inhibition of tissue‐type and urokinase‐type plasminogen activator by plasminogen‐activator inhibitor type 1 and type 2
1988
Molecular analysis in two Tunisian families with combined factor V and factor VIII deficiency
2010
Neuroserpin, a Brain-associated Inhibitor of Tissue Plasminogen Activator Is Localized Primarily in Neurons
1997
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
2006 StandoutNobel
Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein
1998
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Bifidobacteria can protect from enteropathogenic infection through production of acetate
2011 StandoutNature
Thrombosis as an intravascular effector of innate immunity
2012 Standout
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura
1998 Standout
Cleavage of ultra‐large von Willebrand factor by ADAMTS‐13 under flow conditions
2005
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes
2009
Hemostasis in the Mouse (Mus musculus): A Review
1999
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
1997
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
2013 StandoutNobel
Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism
1991 StandoutNobel
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia
1989
Role of the P2 Residue in Determining the Specificity of Serpins
1996
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.
1990
Serpin Structure, Mechanism, and Function
2002 Standout
Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor
1987
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
2011 StandoutNobel
Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
2010
A major estrogen-regulated protein secreted from the liver of Xenopus laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA and hormonal induction of mRNA.
1992
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
2016
Localization of vitronectin binding domain in plasminogen activator inhibitor-1.
1994
Gold(I)-Catalyzed Oxidative Cleavage of a C−C Double Bond in Water
2006
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor.
1988
Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging
2019
EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII
2009
Ligand Effects in Homogeneous Au Catalysis
2008 Standout
Resolution of Michaelis Complex, Acylation, and Conformational Change Steps in the Reactions of the Serpin, Plasminogen Activator Inhibitor-1, with Tissue Plasminogen Activator and Trypsin
2001
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
2006
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
1995
Platelets in Inflammation and Thrombosis
2003
Neuroserpin, an axonally secreted serine protease inhibitor.
1996
Black Phosphorus Quantum Dots with Renal Clearance Property for Efficient Photodynamic Therapy
2017
Surface receptors for urokinase plasminogen activator
1988
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
CpG Mutations in the Reactive Site of Human C1 ¯
1989
Human Plasminogen Activator Inhibitor-1 (PAI-1) Deficiency: Characterization of a Large Kindred With a Null Mutation in the PAI-1 Gene
1997
Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.
1990 StandoutNobel
Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix.
1991
Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor.
1994 StandoutNobel
Molecular phylogenetics and the origins of placental mammals
2001 StandoutNature
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor
1998
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
1990 StandoutScience
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
2002
Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency
2010
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.
1995
Soluble plasma-derived von Willebrand factor assembles to a haemostatically active filamentous network
2007
Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions
2000
Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.
1989
On the target specificity of plasminogen activator inhibitor 1: the role of heparin, vitronectin, and the reactive site
1991
SEC23B is required for the maintenance of murine professional secretory tissues
2012
Mutagenesis of recombinant protein C inhibitor reactive site residues alters target proteinase specificity
1994
Wound-Healing Studies in Transgenic and Knockout Mice
2004
Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties.
1990
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.
1987
Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors
1987
Gold-Catalyzed Organic Transformations
2008 Standout
Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26
2000
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Genetic Dissection of the Host Tropism of Human-Tropic Pathogens
2015
The COPII pathway and hematologic disease
2012
Works of Angela Yang being referenced
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
2001 StandoutNature
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
2017 Nature
Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.
1989
von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]
1994
Spontaneous thrombosis in mice carrying the factor V Leiden mutation
2000
von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]
1994
Genotype-phenotype correlation in combined deficiency of factor V and factor VIII
2008
cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
1986
The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis
2003
Biosynthetic origin and functional significance of murine platelet factor V
2003
Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele
2010
von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene
1995
Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
1992
Yolk–Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic–Plasmonic Hybrid Theranostic Platform
2017
The Structure and Function of Murine Factor V and Its Inactivation by Protein C
1998
The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival
1999
Fine Mapping of Monoclonal Antibody Epitopes on Human von Willebrand Factor Using a Recombinant Peptide Library
1992
Plasminogen Is a Critical Host Pathogenicity Factor for Group A Streptococcal Infection
2004 Science