Standout Papers
Citation Impact
Citing Papers
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
2014
Role of Caspases, Bid, and p53 in the Apoptotic Response Triggered by Histone Deacetylase Inhibitors Trichostatin-A (TSA) and Suberoylanilide Hydroxamic Acid (SAHA)
2003
Direct coupling of the cell cycle and cell death machinery by E2F
2002
twist is a potential oncogene that inhibits apoptosis
1999
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
1999
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
2009
The role of DNA damage and repair in aging through the prism of Koch-like criteria
2012
The RB and p53 pathways in cancer
2002 Standout
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Apoptosis in cancer
2000 Standout
Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response
2013
Oncogenic kinase signalling
2001 StandoutNature
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
2013 StandoutNobel
The complexity of p53 modulation: emerging patterns from divergent signals
1998
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
2000
Tumor surveillance via the ARF–p53 pathway
1998
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
2004
The ARF/p53 pathway
2000
C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles
2009 StandoutNobel
The Hallmarks of Cancer
2000 Standout
The p53 pathway
1999
MDM2 — master regulator of the p53 tumor suppressor protein
2000
Bacterial Nitric Oxide Extends the Lifespan of C. elegans
2013
The regulation of E2F by pRB-family proteins
1998 Standout
DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation
2014
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
1999 Nature
Intrinsic tumour suppression
2004 Nature
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
2008 StandoutNobel
Regulation of the p53 Tumor Suppressor Protein
1999
Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks
2012 StandoutNobel
Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli
2012
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
2000
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht
2000
Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
2011
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
1998
Genes involved in senescence and immortalization
2000
A cytoprotective perspective on longevity regulation
2013 StandoutNobel
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
2000
Signaling to p53
1998
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
2004 Nature
Mechanisms of switching on p53: a role for covalent modification?
1999
Opposing Effects of Ras on p53
2000
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
The Hallmarks of Aging
2013 Standout
A microRNA polycistron as a potential human oncogene
2005 StandoutNature
Apoptosis and therapy
1999
The Emerging p53 Gene Family
1999 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
2002
Control of apoptosis by p53
2003
Negative control elements of the cell cycle in human tumors
1998 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
1999
Effect of the diet type and temperature on theC. eleganstranscriptome
2017
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
2002
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
1999
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
2000
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
2003 Standout
p19 Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation
1998
Role of the p53-homologue p73 in E2F1-induced apoptosis
2000
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Death Receptors: Signaling and Modulation
1998 StandoutScience
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Surfing the p53 network
2000 StandoutNature
Regulation of p53 stability
1999
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
2013 StandoutNobel
PML is induced by oncogenicrasand promotes premature senescence
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
2000
p53 Mediates Apoptotic Crisis in Primary Abelson Virus-Transformed Pre-B Cells
1999
A role for E2F1 in the induction of apoptosis during thymic negative selection.
2000
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
A Matter of Life and Cell Death
1998 Science
Works of Andrew V. Samuelson being referenced
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
2007 StandoutNobel
The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation
2010
p400 Is Required for E1A to Promote Apoptosis
2005
E1A signaling to p53 involves the p19ARFtumor suppressor
1998
The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals
2014
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins
1997