Standout Papers
Citation Impact
Citing Papers
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
A general-purpose protein design framework based on mining sequence–structure relationships in known protein structures
2019
Impacts of Biodiversity Loss on Ocean Ecosystem Services
2006 StandoutScience
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−
2014
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Intrinsically disordered protein PID‐2 modulates Z granules and is required for heritable piRNA‐induced silencing in the Caenorhabditis elegans embryo
2020
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis
2009 StandoutNobel
Carbohydrate-Protein Interactions in Vascular Biology
1995
De novo design of immunoglobulin-like domains
2022 StandoutNobel
Testicular Germ-Cell Cancer
1997 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Influence of DNA Aptamer Structure on the Specificity of Binding to Taq DNA Polymerase
2003
mTOR Signaling in Growth Control and Disease
2012 Standout
Methods for selection of aptamers to protein targets
2007
Importance of the P2 Glycine of Antithrombin in Target Proteinase Specificity, Heparin Activation, and the Efficiency of Proteinase Trapping as Revealed by a P2 Gly → Pro Mutation
1999
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Applications of aptamers in cancer cell biology
2008
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
2011
Nucleotide signalling during inflammation
2014 StandoutNature
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
Mechanism of Heparin Activation of Antithrombin
1998
Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
2020
Hallmarks of aging: An expanding universe
2023 Standout
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Oligonucleotide inhibitors of human thrombin that bind distinct epitopes
1997
The pH Dependence of Serpin-Proteinase Complex Dissociation Reveals a Mechanism of Complex Stabilization Involving Inactive and Active Conformational States of the Proteinase Which Are Perturbable by Calcium
2001
Tidal wetland stability in the face of human impacts and sea-level rise
2013 StandoutNature
Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal‐Based Sensors
2012 StandoutNobel
Cocultivation of an ultrasmall environmental parasitic bacterium with lytic ability against bacteria associated with wastewater foams
2021
Tumor metastasis: moving new biological insights into the clinic
2013
Sulfotransferases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility
2004
Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics
1995
Development of DNA aptamers using Cell-SELEX
2010
Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST-5)
2000 StandoutNobel
Aptamers as Tools in Molecular Biology and Immunology
1999
Alzheimer's disease
2015
Aptamers as targeted therapeutics: current potential and challenges
2016 Standout
Genomics of the origin and evolution of Citrus
2018 StandoutNature
5′-Adenosinephosphosulfate Lies at a Metabolic Branch Point in Mycobacteria
2002 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Negative regulation of transforming growth factor-β by the proteoglycan decorin
1990 StandoutNature
Role of Arginine 129 in Heparin Binding and Activation of Antithrombin
2000
An Aptamer–Doxorubicin Physical Conjugate as a Novel Targeted Drug‐Delivery Platform
2006
The Energetic Linkage of GTP Hydrolysis and the Synthesis of Activated Sulfate
1994
Influence of the P5 Residue on α1-Proteinase Inhibitor Mechanism
1998
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
An enzyme-linked oligonucleotide assay
1996
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
The structure of a Michaelis serpin-protease complex.
2001
P2Y12Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain
2008
Cyclic GMP–AMP signalling protects bacteria against viral infection
2019 Nature
De novo design of a non-local β-sheet protein with high stability and accuracy
2018 StandoutNobel
What do dysfunctional serpins tell us about molecular mobility and disease?
1995
A Novel Class of Small Functional Peptides that Bind and Inhibit Human α-Thrombin Isolated by mRNA Display
2003
Targeting cancer cells with nucleic acid aptamers
2010
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
The genetic legacy of the Quaternary ice ages
2000 StandoutNature
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
Current approaches in SELEX: An update to aptamer selection technology
2015
ComFC mediates transport and handling of single-stranded DNA during natural transformation
2022
Clinical imaging of cancer metastasis
2000
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Sulfate Metabolism in Mycobacteria
2006 StandoutNobel
2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia
2015
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
2005
Aptamers as radiopharmaceuticals for nuclear imaging and therapy
2015
CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
2008
Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.
1995
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Characterization of the P2‘ and P3‘ Specificities of Thrombin Using Fluorescence-Quenched Substrates and Mapping of the Subsites by Mutagenesis,
1996
Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene.
1990
Functional Nucleic Acid Sensors
2009 Standout
Mechanism of Acceleration of Antithrombin-Proteinase Reactions by Low Affinity Heparin
1995
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics
1999 Standout
Serpin Structure, Mechanism, and Function
2002 Standout
Isolation of high-affinity GTP aptamers from partially structured RNA libraries
2002 StandoutNobel
Therapeutic Nanoparticles for Drug Delivery in Cancer
2008 Standout
Nucleic Acid Selection and the Challenge of Combinatorial Chemistry
1997
Development of NIR Fluorescent Dyes Based on Si–rhodamine for in Vivo Imaging
2012
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity
1988
The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.
1991
Signaling Aptamer/Protein Binding by a Molecular Light Switch Complex
2004
Evaluation of template‐based modeling in CASP13
2019
Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation
2015
Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors
2011
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions
1998 Standout
Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.
1990
Metabolic reprogramming and cancer progression
2020 StandoutScience
Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants
1990
De novo design of small beta barrel proteins
2023 StandoutNobel
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
2015 StandoutNobel
Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
1992
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Depletion, Degradation, and Recovery Potential of Estuaries and Coastal Seas
2006 StandoutScience
Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins
2018
A Global Map of Human Impact on Marine Ecosystems
2008 StandoutScience
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
2012
When oceans meet: a teleost shows secondary intergradation at an Indian–Pacific interface
1998
Mutagenesis of recombinant protein C inhibitor reactive site residues alters target proteinase specificity
1994
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Template‐based modeling by ClusPro in CASP13 and the potential for using co‐evolutionary information in docking
2019 StandoutNobel
CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum
2015 StandoutNobel
Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles
2009
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Proteoglycans in Cell Regulation
1989
Maps of Pleistocene sea levels in Southeast Asia: shorelines, river systems and time durations
2000 Standout
Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs
1995
Molecular Evolution of Functional Nucleic Acids with Chemical Modifications
2010
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
2015
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
2021
Works of Andrew Stephens being referenced
Specific PET Imaging of xC− Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism
2011
Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors
2014
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study
2015
A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core
2017 Standout
Kinetic Characterization of the Proteinase Binding Defect in a Reactive Site Variant of the Serpin, Antithrombin
1995
Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study
2014
High-affinity RNA ligands to human α-thrombin
1994
Positron emission tomography evaluation of residual radiographic abnormalities in postchemotherapy germ cell tumor patients.
1996
Site-directed mutagenesis of the reactive center (serine 394) of antithrombin III.
1988
Expression of functionally active human antithrombin III.
1987
Antithrombin-III Denver, a reactive site variant.
1987
Tumor targeting by an aptamer.
2006
Sequence variation in heparin octasaccharides with high affinity for antithrombin III
1984
Acyclic Analogues of Adenosine Bisphosphates as P2Y Receptor Antagonists: Phosphate Substitution Leads to Multiple Pathways of Inhibition of Platelet Aggregation
2002
Quaternary sequence stratigraphy of the Brisbane River delta, Moreton Bay, Australia
1992
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors
2016
First-in-human phase I study exploring three schedules of OSI-027, a novel small molecule TORC1/TORC2 inhibitor, in patients with advanced solid tumors and lymphoma.
2010
Late Quaternary hydrological changes in the Gulf of Carpentaria
1985 Nature
Evaluation of critical groups required for the binding of heparin to antithrombin.
1984