Citation Impact
Citing Papers
Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20
2005
Kinetochore Localization of Spindle Checkpoint Proteins: Who Controls Whom?
2004
The Centromeric Protein Sgo1 Is Required to Sense Lack of Tension on Mitotic Chromosomes
2005 Science
Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae
2004
A dual role for Bub1 in the spindle checkpoint and chromosome congression
2005
Palladium‐Catalyzed Cross‐Coupling Reactions in Total Synthesis
2005 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Validating Aurora B as an anti-cancer drug target
2006
Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5‐Trisubstituted Benzenes
2014
A Cul3-Based E3 Ligase Removes Aurora B from Mitotic Chromosomes, Regulating Mitotic Progression and Completion of Cytokinesis in Human Cells
2007
MYC on the Path to Cancer
2012 Standout
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
2007
Epigenetics: A Landscape Takes Shape
2007 Standout
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
2005
Chromatin Modifications and Their Function
2007 Standout
Inhibition of Aurora-A suppresses epithelial–mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Rethinking amide bond synthesis
2011 StandoutNature
BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase
2009
Catalytic Enantioselective Reformatsky Reaction with Aldehydes
2008 StandoutNobel
Aurora B Is Enriched at Merotelic Attachment Sites, Where It Regulates MCAK
2006
CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
2012 Standout
Targeted treatments in colorectal cancer: state of the art and future perspectives
2010
A Powerful Chiral Counteranion Motif for Asymmetric Catalysis
2009 StandoutNobel
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Polo-like Kinase 1 Creates the Tension-Sensing 3F3/2 Phosphoepitope and Modulates the Association of Spindle-Checkpoint Proteins at Kinetochores
2005
Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding
2009
The cellular geography of Aurora kinases
2003
Correcting improper chromosome–spindle attachments during cell division
2004
Colorectal cancer
2013 Standout
Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
2007 Standout
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Aurora-A — A guardian of poles
2005
Stuck in Division or Passing through
2004
Aneuploidy: a matter of bad connections
2005
Oxazinanones as chiral auxiliaries: synthesis and evaluation in enolate alkylations and aldol reactions
2006
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs
2008
The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments
2004
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Aurora Kinases and Their Inhibitors: More Than One Target and One Drug
2007
Highly Diastereo‐ and Enantioselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding
2006
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment
2005
Aurora Kinase Promotes Turnover of Kinetochore Microtubules to Reduce Chromosome Segregation Errors
2006
Kinetochore capture and bi-orientation on the mitotic spindle
2005
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
2010
Proline-catalysed Mannich reactions of acetaldehyde
2008 StandoutNatureNobel
The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation
2004
On the road to cancer: aneuploidy and the mitotic checkpoint
2005
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint
2004
Targeting polo-like kinase 1 for cancer therapy
2006
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation
2005 Nature
Cell cycle kinases as therapeutic targets for cancer
2009
The spindle checkpoint: tension versus attachment
2005
Aurora-kinase inhibitors as anticancer agents
2004
The spindle-assembly checkpoint in space and time
2007 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Asymmetric 1,3-Dipolar Cycloaddition Reactions
1998 Standout
Recent advances in olefin metathesis and its application in organic synthesis
1998 StandoutNobel
Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers
2007 StandoutNobel
The dynamic kinetochore-microtubule interface
2004
3d Transition Metals for C–H Activation
2018 Standout
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Chemical Genetics
2006
Synthesis of Dictyopterene A: Optically Active Tributylstannylcyclopropane as a Chiral Synthon
2000
A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin
2008
Chemistry of Polyvalent Iodine
2008 Standout
The Reformatsky reaction in organic synthesis. Recent advances
2004
The intramolecular Stille reaction
1999
The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7
2000
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
2010 Nobel
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
2015
Oxiranyl Anions and Aziridinyl Anions
1996
Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression
2004
Samarium(II)-Iodide-Mediated Cyclizations in Natural Product Synthesis
2004 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Synthesis of enantiomerically pure tributylstannylcyclopropanes through lipase-catalyzed reaction
1998
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
The Origin of Chalcogen-Bonding Interactions
2017 Standout
Total Synthesis of the CP-Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A). 1. Racemic and Asymmetric Synthesis of Bicyclo[4.3.1] Key Building Blocks
2002
Synthesis of pyrrolizidine bases by highly diastereoselective and regioselective catalytic carbon-hydrogen insertion reactions of chiral pyrrolidinediazoacetamides
1996
The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7
2000
Stereoselective Cyclopropanation Reactions
2003 Standout
Switching the Chemoselectivity in the Amination of 4-Chloroquinazolines with Aminopyrazoles
2009
Integrated Cross-Coupling Strategy for an α-Carboline-Based Aurora B Kinase Inhibitor
2015
Highly Diastereo‐ and Enantioselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding
2006
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Eine Entdeckung während der Totalsynthese — Epimerisierung der CP-Verbindungen an C7: Ist (7S)-CP-263,114 ein Fermentationsprodukt?
1999
Additions of Organometallic Reagents to CN Bonds: Reactivity and Selectivity
1998 Standout
Stereospezifische, schwefelunterstützte Spaltung eines Spirocylobutanons: Synthese einer vollständig funktionalisierten Vorstufe der CP-Verbindungen
1999
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Enantioselective oxidation of thioethers1: An easy route to enantiopure C2 symmetrical bis-methylsulfinylbenzenes
1993
Evolution of a Synthetic Approach to CP-263,114
2001
Die Chemie vicinaler Diamine
1998
Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells
2006
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
2011 Science
Small-Molecule H-Bond Donors in Asymmetric Catalysis
2007 Standout
The chromosomal passenger complex: guiding Aurora-B through mitosis
2006
Reinvestigation of the dimerisation process forming isoglaucanic acid
1999
The Cinchona Primary Amine-Catalyzed Asymmetric Epoxidation and Hydroperoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide
2013 StandoutNobel
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Hydrozirconation of alkenyloxirane derivatives: Preparation of cycloalkylmethanols
1998
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis
2010
α-Amino acids as chiral educts for stereoselective syntheses of pyrrolidine and pyrrolizidine systems
1995
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
2003
Application of the grubbs ring-closing metathesis for the construction of a macrocyclic ansa-bridge. Synthesis of the tricyclic core of roseophilin
1997
Peroxycarbenium-Mediated C−C Bond Formation: Applications to the Synthesis of Hydroperoxides and Peroxides
2000
Synthesis of an immunomodulator (+)-conagenin and its analogs
2007
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
2012
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase
2005
Synthesis of the oxa-bridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin
2007 StandoutNobel
The Vinylogous Aldol Reaction: A Valuable, Yet Understated Carbon−Carbon Bond-Forming Maneuver
2000 Standout
Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis
1998 StandoutNobel
Stereoselective grignard reactions to α-amino nitrones. Synthesis of optically active α-aminohydroxylamines and 1,2-diamines
1997
The Art of Innovation in Organic Chemistry: Synthetic Efforts toward the Phomoidrides
2003
Filamentous Phage Display in the New Millennium
2005
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Works of Andrew Mortlock being referenced
Bifunctional chiral auxiliaries 1: the aldol reaction between dialkylboron enolates of 1,3-dipropionyl-trans-4,5-tetramethyleneimidazolidin-2-one and aldehydes
1991
Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity
2008
Suppression of gene expression by a cell-permeable Tet repressor
2003
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
2008
Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines
2008
Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reactionElectronic supplementary information (ESI) available: crystal data for 13a. See http://www.rsc.org/suppdata/p1/b2/b202752f/
2002
AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis
2007
Asymmetric synthesis of (1R,8S)- and (1S,8S)-1-hydroxypyrrolizidin-3-ones via the aldol reaction between N-boc-(S)-prolinal and chiral acetate enolate equivalents derived from (S)- and (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH3]
1992
Approaches to the γ-lactone unit of CP-225,917 and CP-263,114
2002
Bifunctional chiral auxiliaries 5: The synthesis of 1,3-diacylimidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones from 1,2-diamines
1993
Two New Syntheses of a 4-Aminopyrazole: Condensation of an N-Substituted Vinamidinium Salt with a Functionalized Hydrazine
2007
Synthesis of the Bicyclo[4.4.1]decenone Core of CP-225,917 and CP-263,114
1998
Bifunctional chiral auxiliaries 4: Alkylation of enolates derived from 1,3-diacyl-trans-4,5-tetramethyleneimidazolidin-2-ones
1992
Total Syntheses of (−)-Papuamine and (−)-Haliclonadiamine
1996
First Examples of Episulfone Substitution Reactions via .alpha.-Sulfonyl Carbanion Intermediates
1994
Bifunctional chiral auxiliaries 7: Aldol reactions of enolates derived from 1,3-diacyl-imidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones
1994
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
2003
Bifunctional chiral auxiliaries 3: Synthesis of homochiral 1,3-diols via asymmetric aldol reactions of dialkylboron enolates of 1,3-dipropionyl-trans-4,5-diphenyl-imidazolidin-2-one and aldehydes
1991