Standout Papers
Citation Impact
Citing Papers
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
2002
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
2006 Science
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
2007
Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives
2009
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
An Olfactory Sensory Map in the Fly Brain
2000 StandoutNobel
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY
1995
An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats
1994
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining: Table 1.
2008
Anatomical Profiling of G Protein-Coupled Receptor Expression
2008
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
Tetrathiafulvalene Derivatives as NLO-phores: Synthesis, Electrochemistry, Raman Spectroscopy, Theoretical Calculations, and NLO Properties of Novel TTF-Derived Donor-π-Acceptor Dyads
2001
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4
2007
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
1995 StandoutNatureNobel
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
2003 Standout
Amyotrophic lateral sclerosis
2011 Standout
gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle
1999
The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer
2003
Survey of Somatic Mutations in Tuberous Sclerosis Complex (TSC) Hamartomas Suggests Different Genetic Mechanisms for Pathogenesis of TSC Lesions
2001
Identification and Characterization of Three New Alternatively Spliced μ-Opioid Receptor Isoforms
1999
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization
2000
Cognitive impairment in amyotrophic lateral sclerosis
2007
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
STRA6 is critical for cellular vitamin A uptake and homeostasis
2014
Decoding ALS: from genes to mechanism
2016 StandoutNature
Biomarkers in amyotrophic lateral sclerosis
2008
Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
2003 StandoutNobel
G-protein-coupled receptor heterodimerization modulates receptor function
1999 Nature
Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
2007
Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease — a contiguous gene syndrome
1994
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
2007
G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding
2011
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
A Nobel for Smell
2004 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Molecular genetic advances in tuberous sclerosis
2000
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
2008
A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression
2001 StandoutNobel
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination
2008
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
2007
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila
2001 StandoutNobel
Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system
2001
The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors
2004
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Molecular tinkering of G protein-coupled receptors: an evolutionary success
1999
Genomic Rearrangements and Gene Copy-Number Alterations as a Cause of Nervous System Disorders
2006
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence
2009
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
1988 StandoutNatureNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Bacterial DNA repair by non-homologous end joining
2007
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
2008
RTP Family Members Induce Functional Expression of Mammalian Odorant Receptors
2004
The GAP-Related Domain of Tuberin, the Product of the TSC2 Gene, is a Target for Missense Mutations in Tuberous Sclerosis
1997
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
2002
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
Changes in the periplasmic linker and in the expression level affect the activity of ToxR and λ‐ToxR fusion proteins in Escherichia coli
1998 StandoutNobel
Glia cells in amyotrophic lateral sclerosis: New clues to understanding an old disease?
2007
Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining
2007
Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size
2001
New Concepts in Tetrathiafulvalene Chemistry
2001
Synthesis and properties of push–pull chromophores for second-order nonlinear optics derived from π-extended tetrathiafulvalenes (TTFs)
2002
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
1986
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Reversible Three-State Switching of Luminescence: A New Twist to Electro- and Photochromic Behavior
2006 StandoutNobel
Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.
1996 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Dications of Fluorenylidenes. Electronic Effects on the Paratropicity/Antiaromaticity of 2,7-Disubstituted Fluorenyl Cations
1998
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
1989 StandoutNobel
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Intramolecular Electronic Interactions in Conjugated Ferrocene−π-Extended-Tetrathiafulvalene Donor-π-Donor Molecular Hybrids
2000
2,6-Dialkoxy-9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene Derivatives: Synthesis, Electrochemistry and X-ray Crystal Structures of Neutral and Dication Species
2000
Nonhomologous End-Joining in Bacteria: A Microbial Perspective
2007
Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites
1986
A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis
2008
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
1985 Standout
Photochemistry of the π‐Extended 9,10‐Bis(1,3‐dithiol‐2‐ylidene)‐ 9,10‐dihydroanthracene System: Generation and Characterisation of the Radical Cation, Dication, and Derived Products
2001
Reduced frequency of ALS in an ethnically mixed population
2009
Tetrathiafulvalenes, Oligoacenenes, and Their Buckminsterfullerene Derivatives: The Brick and Mortar of Organic Electronics
2004 Standout
DNA Recognition by Cys2His2 Zinc Finger Proteins
2000
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.
1999
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Detection of β 2 -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
2000
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Synthesis and non-linear optical properties of mono-pyrrolotetrathiafulvalene derived donor–π–acceptor dyads
2004
Remarkable Stability of High Energy Conformers in Self-Assembled Monolayers of a Bistable Electro- and Photoswitchable Overcrowded Alkene
2011 StandoutNobel
WormBook
2008
The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae
2012
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
2004
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Allosteric activation of the CaR by l -amino acids
2000 StandoutNobel
Dications of Fluorenylidenes. Use of Magnetic Properties To Evaluate the Antiaromaticity of the Dication of Tetrabenzo[5.5]fulvalene and Substituted Fluorenyl Cations
1999
The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
1994
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
1997 StandoutNobel
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.
1998
Ethnic variation in the incidence of ALS
2007
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
1985
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Dications of Fluorenylidenes. Relationship between Electrochemical Oxidation Potentials and Antiaromaticity in Diphenyl-Substituted Fluorenyl Cations
2002
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
Inverse, protean, and ligand‐selective agonism: matters of receptor conformation
2001
Antiaromaticity in Fluorenylidene Dications. Experimental and Theoretical Evidence for the Relationship between the HOMO/LUMO Gap and Antiaromaticity
2004
Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions.
1996
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Works of Andrew Green being referenced
Domain Structure of a NHEJ DNA Repair Ligase from Mycobacterium tuberculosis
2005
“True” sporadic ALS associated with a novel SOD‐1 mutation
2002
The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor
1994
Clonality of tuberous sclerosis harmatomas shown by non-random X-chromosome inactivation
1996
NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation
2007
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients
1994
Evolutionary and Functional Conservation of the DNA Non-homologous End-joining Protein, XLF/Cernunnos
2006
Heterodimerization is required for the formation of a functional GABAB receptor
1998 Nature
First implication ofSTRA6mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to theSTRA6phenotype
2011
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
2006
A novel bacterial vector system for monitoring protein-protein interactions in the cAMP-dependent protein kinase complex
1997 StandoutNobel
Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase
2011
Mycobacteriophage Exploit NHEJ to Facilitate Genome Circularization
2006
AnEcoRV polymorphism in exon 40 of the tuberous sclerosis 2 (TSC2) gene
1997
Synthesis of Conjugated Tetrathiafulvalene (TTF)-π-Acceptor Molecules − Intramolecular Charge Transfer and Nonlinear Optical Properties
2001
Alteration of zif268 zinc-finger motifs gives rise to non-native zinc-co-ordination sites but preserves wild-type DNA recognition
1998
chk-1 is an Essential Gene and is Required for an S-M Checkpoint During Early Embryogenesis
2004
A novel candidate region for ALS on chromosome 14q11.2
2004
Dications of Fluorenylidenes: Conformational and Electronic Effects on the Paratropicity/Antiaromaticity of Fluorenyl Cations with Cyclic Substituents
1997
The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants
1984
Structure of a NHEJ Polymerase-Mediated DNA Synaptic Complex
2007 Science
Elevated serum angiogenin levels in ALS
2006
Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2 antagonist pirenperone
1983
Donor-π-Acceptor Species Derived from Functionalised 1,3-Dithiol-2-ylidene Anthracene Donor Units Exhibiting Photoinduced Electron Transfer Properties: Spectroscopic, Electrochemical, X-Ray Crystallographic and Theoretical Studies
1998
New 1,3-dithiol-2-ylidene donor–π–acceptor chromophores with intramolecular charge-transfer properties, and related donor–π–donor molecules: synthesis, electrochemistry, X-ray crystal structures, non-linear optical properties and theoretical calculations
1998
Loss of heterozygosity in tuberous sclerosis hamartomas.
1996
Duplication of 8p23.1: a cytogenetic anomaly with no established clinical significance.
1998