Standout Papers
- Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis. (2002)
- Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease (2001)
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice (1998)
- Brca2 is required for embryonic cellular proliferation in the mouse. (1997)
Citation Impact
Citing Papers
Biallelic Inactivation of BRCA2 in Fanconi Anemia
2002 Science
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
2003
Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans
2002 Science
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
2003 Standout
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
2003 Nature
Hallmarks of Cancer: The Next Generation
2011 Standout
CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1
2003
Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
2000
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
JunB is essential for mammalian placentation
1999
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
1999 StandoutNobel
Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
1998
Apoptosis in the nervous system
2000 StandoutNature
Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells
2000
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
2001
Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts
2003
Activation of NF-κB by FADD, Casper, and Caspase-8
2000
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
2006 StandoutNature
Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation
2000
The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
2012
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
The IKK complex: an integrator of all signals that activate NF-κB?
2000
Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition
2001
Cell-cycle checkpoints and cancer
2004 StandoutNature
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma
2003
NFAT Signaling
2002
NF-κB in cancer: from innocent bystander to major culprit
2002 Standout
Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death
2001
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Structural Basis for the Inhibition of Caspase-3 by XIAP
2001
Apoptosis in mouse embryos: Elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice
1998
From Cell Structure to Transcription: Hippo Forges a New Path
2006
Histone H2AX
2003
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
2000
Transcriptional regulation by calcium, calcineurin, and NFAT
2003 Standout
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
2000
Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice
2003
Stem and progenitor cells: the premature desertion of rigorous definitions
2003
Cellular survival: a play in three Akts
1999 Standout
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
2002 StandoutNobel
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Cell Death
2004 Standout
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
NFAT signaling in vertebrate development
2001
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
2000 StandoutNobel
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
Necrotic death as a cell fate
2006
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
NF-κB signaling pathways in mammalian and insect innate immunity
2001
Activation of the NF-κB pathway by Caspase 8 and its homologs
2000
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
2002 Nature
Mitochondria, Oxidants, and Aging
2005 Standout
Missing Pieces in the NF-κB Puzzle
2002 Standout
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
2002
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
2003
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Checking on DNA damage in S phase
2004
Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
2005 Standout
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
2000
Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation1
2001
Terminal Bronchioles Harbor a Unique Airway Stem Cell Population That Localizes to the Bronchoalveolar Duct Junction
2002
Cell Death in Development
1999
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
2001 StandoutNobel
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
2001
Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development
1998
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
1998
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
2007
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine
2003
FADD/MORT1, a signal transducer that can promote cell death or cell growth
1999
Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti
2000
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
2001
The immune response of Drosophila
2003 StandoutNatureNobel
Nucleocytoplasmic O-glycosylation: O-GlcNAc and functional proteomics
2001
Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase
2000 StandoutNobel
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
2003
Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature
2001
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway
2001
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster
2003
Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis
2003
Hippo signaling in organ size control
2007
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti
2000
NF-κB regulation in the immune system
2002 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
1999
The spe-10 mutant has longer life and increased stress resistance☆
1999
<I>Lps2</I>: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
2006 StandoutNobel
NF-κB and cell-cycle regulation: the cyclin connection
2001
JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila
2003
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
2003 Nature
CSN3 interacts with IKKγ and inhibits TNF‐ but not IL‐1‐induced NF‐κB activation
2001
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Toll-like receptors: critical proteins linking innate and acquired immunity
2001 Standout
The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover
2006
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
Activation of the IκB Kinases by RIP via IKKγ/NEMO-mediated Oligomerization
2000
Signal transduction by tumor necrosis factor and its relatives
2001
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Collaboration of Brca1 and Chk2 in tumorigenesis
2004
A Novel X-Linked Disorder of Immune Deficiency and Hypohidrotic Ectodermal Dysplasia Is Allelic to Incontinentia Pigmenti and Due to Mutations in IKK-gamma (NEMO)
2000
Epithelial NEMO links innate immunity to chronic intestinal inflammation
2007 Nature
Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II
1999
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
2002
A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis
2004
Endonuclease G is an apoptotic DNase when released from mitochondria
2001 Nature
Isolation of multipotent adult stem cells from the dermis of mammalian skin
2001
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor–induced proliferation
2008
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
2000 Standout
Mature T Cells Depend on Signaling through the IKK Complex
2003
TNF-Induced Signaling in Apoptosis
1999
Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons
2003
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
1999
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
2004
NF-κB at the crossroads of life and death
2002 Standout
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β
2002
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals
2007 Standout
Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans
2001
CD95's deadly mission in the immune system
2000 Nature
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
2004 StandoutNobel
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster
2004
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
Mitochondrial “swirls” induced by oxygen stress and in theDrosophilamutanthyperswirl
2004
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms
2002
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah
1998 Science
The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β
2002
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies
1999
Double indemnity: p53, BRCA and cancer
1997
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
2003 StandoutNobel
Hypoxia Links ATR and p53 through Replication Arrest
2002
The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans
1999
Death Receptors: Signaling and Modulation
1998 StandoutScience
Pten is essential for embryonic development and tumour suppression
1998 Standout
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells
2002
Impaired Fas Response and Autoimmunity in Pten +/− Mice
1999 Science
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
2001
BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases
1999
Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
2001
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
2003
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
1998
Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release
2000
Loss of PTEN expression leading to high Akt activation in human multiple myelomas
2000
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
FADD is required for multiple signaling events downstream of the receptor Fas.
1999
CIKS, a connection to IκB kinase and stress-activated protein kinase
2000
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
2004
The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF
2001
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase
2003
Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
2007
Exogenous Smac Induces Competence and Permits Caspase Activation in Sympathetic Neurons
2002
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
2003
The Emerging Significance of O-GlcNAc in Cellular Regulation
2002
Mitochondrial disease in superoxide dismutase 2 mutant mice
1999
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
Calcium - a life and death signal
1998 StandoutNature
Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia
1999
Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
1999 Science
Regulating mammalian checkpoints through Cdc25 inactivation
2003
Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex
2000 Science
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
2000 Science
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Direct Neural Fate Specification from Embryonic Stem Cells
2001
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
2000
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
2000 StandoutNobel
A Matter of Life and Cell Death
1998 Science
The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol
1999
Works of Andrew Elia being referenced
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
1998
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
2012
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
2004
Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure
2001
Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
2000
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
2001 Nature
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
1998 Nature
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
1998
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
2001 StandoutNobel
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
2002
Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation
1997
Expression of human FALS SOD in motorneurons of Drosophila
1999
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
1998
Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells
2000
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
1998
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
2002
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
2000
Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS
2000
In Vivo Evidence That Caspase-3 Is Required for Fas-Mediated Apoptosis of Hepatocytes
1999
Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
1999
Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice
2000
Retinal Stem Cells in the Adult Mammalian Eye
2000 Science
Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner
2002
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
1999
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
1998 Science