Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints
2002
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
2003 StandoutScience
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
2014
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex
2009
The DNA-damage response in human biology and disease
2009 StandoutNature
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
2000
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
2001
A key role for replication factor C in DNA replication checkpoint function in fission yeast
1999
Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α
2004 StandoutNobel
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
2000
Cell-cycle checkpoints and cancer
2004 StandoutNature
What the Myddosome structure tells us about the initiation of innate immunity
2011
Meiotic DNA replication checkpoint control in fission yeast
1999 StandoutNobel
Chk2 kinase — a busy messenger
2001
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
1992
DNA Damage-dependent and -independent Phosphorylation of the hRad9 Checkpoint Protein
2001
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
2004
Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex
1999
DNA damage checkpoints in mammals
2005
The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9
2000
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
TLR-dependent T cell activation in autoimmunity
2011
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
2001 Nature
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
2000 Nature
The Chk2 protein kinase
2004
Physical Interactions among Human Checkpoint Control Proteins HUS1p, RAD1p, and RAD9p, and Implications for the Regulation of Cell Cycle Progression
2000
Structure and Expression of the TREX1 and TREX2 3′→5′ Exonuclease Genes
2001
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
Human and Mouse Homologs of theSchizosaccharomyces pombe rad17Cell Cycle Checkpoint Control Gene
1999
Mitotic DNA damage and replication checkpoints in yeast
1998
Desirable cell death during anticancer chemotherapy
2010
The FHA Domain Is a Modular Phosphopeptide Recognition Motif
1999
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Identification and Characterization of Human MUS81-MMS4 Structure-specific Endonuclease
2003 StandoutNobel
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex
2001
The PCNA–RFC Families of DNA Clamps and Clamp Loaders
2004
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
2002
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
2001 Nature
Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity
2000
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
2000
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
1999
Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes
2012
Human DNA Damage Checkpoint Protein hRAD9 Is a 3′ to 5′ Exonuclease
2000 StandoutNobel
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
1999
Excision of 3′ Termini by the Trex1 and TREX2 3′→5′ Exonucleases
2001
CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast
2000 StandoutNobel
Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation
2009
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
Proteomics to study genes and genomes
2000 StandoutNature
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth
2008
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005
DNA Distress: Just Ring 9-1-1
2009 StandoutNobel
HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV Irradiation
1999
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Rapid Destruction of Human Cdc25A in Response to DNA Damage
2000 Science
Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.
2001
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
2000 Science
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress
2000
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 StandoutScience
Zymographic Techniques for the Analysis of Matrix Metalloproteinases and their Inhibitors
2005
A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints
2000 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
2000
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
2000
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1
2000
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
2000
DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding
1999
The G2-phase DNA-damage checkpoint
2000
Quality Control by DNA Repair
1999 StandoutScienceNobel
The Human G2 Checkpoint Control Protein hRAD9 Is a Nuclear Phosphoprotein That Forms Complexes with hRAD1 and hHUS1
1999
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
2000
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Basis for the Checkpoint Signal Specificity That Regulates Chk1 and Cds1 Protein Kinases
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.
1994 StandoutNobel
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
1999 Science
The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.
1992 StandoutNobel
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
1999 Science
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Surfing the p53 network
2000 StandoutNature
Genetic Analysis of Yeast RPA1 Reveals Its Multiple Functions in DNA Metabolism
1998
14-3-3 Proteins: Structure, Function, and Regulation
2000 Standout
Cancer Genome Landscapes
2013 StandoutScience
Mechanisms of Diabetic Complications
2013 Standout
Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9
2000
ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation
2001
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
2005
P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
2000
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1999
Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1
1999
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
2000
The G2 DNA damage checkpoint targets both Wee1 and Cdc25
2000
Human DNA Repair Genes
2001 StandoutScienceNobel
The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.
1998
Accumulation of a microtubule-binding protein, pp170, at desmosomal plaques
1992
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
RAD1,a Human Structural Homolog of theSchizosaccharomyces pombe RAD1Cell Cycle Checkpoint Gene
1998
cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.
1992
Fission Yeast cdc24+ Encodes a Novel Replication Factor Required for Chromosome Integrity
1998
Immunogenic Cell Death in Cancer Therapy
2012 Standout
Works of Andrew E. Parker being referenced
Identification of a Human Homologue of theSchizosaccharomyces pombe rad17+ Checkpoint Gene
1998
Expression profiling of metalloproteinases and their inhibitors in cartilage
2004
A Human Homologue of the Schizosaccharomyces pombe rad1+ Checkpoint Gene Encodes an Exonuclease
1998
Targeting Toll-like receptors: emerging therapeutics?
2010
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
1999
STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation
2012
Localization of the Cis-Enhancer Element for Mouse Type X Collagen Expression in Hypertrophic Chondrocytes In Vivo
2008
The Schizosaccharomyces pombe rad11+ Gene Encodes the Large Subunit of Replication Protein A
1997
Identification of a human homologue of the Schizosaccharomyces pombe rad17 checkpoint gene.
1999
Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing
1991
Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.
1991