Standout Papers
Citation Impact
Citing Papers
1H,15N and13C NMR assignments of the 434 repressor fragments 1–63 and 44–63 unfolded in 7 M urea
1992 StandoutNobel
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly
2008
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
An Analytical Solution to the Kinetics of Breakable Filament Assembly
2009 Science
Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I
2006
Thermodynamic prediction of protein neutrality
2005 StandoutNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Nucleation of protein fibrillation by nanoparticles
2007
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation
2009
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Structure of an Intermediate State in Protein Folding and Aggregation
2012 Science
The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide
2010
Globular Tetramers of β2-Microglobulin Assemble into Elaborate Amyloid Fibrils
2009
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
The SsrA–SmpB system for protein tagging, directed degradation and ribosome rescue
2000
Evidence for the Existence of a Secondary Pathway for Fibril Growth during the Aggregation of Tau
2012
From molecular to modular cell biology
1999 StandoutNatureNobel
The Kinetics of Nucleated Polymerizations at High Concentrations: Amyloid Fibril Formation Near and Above the “Supercritical Concentration”
2006
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
2002
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Clp-mediated proteolysis in Gram-positive bacteria is autoregulated by the stability of a repressor
2001
Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis
2015
Thermophilic Adaptation of Proteins
2001
From Levinthal to pathways to funnels
1997 Standout
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid
2007
Principles of protein folding — A perspective from simple exact models
1995
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A
1998 StandoutNobel
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme
2002
Analysis of the Minimal Amyloid-forming Fragment of the Islet Amyloid Polypeptide
2001
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Simplified proteins: minimalist solutions to the ‘protein folding problem’
1998 StandoutNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure
2005 Nature
Sculpting the Proteome with AAA+ Proteases and Disassembly Machines
2004
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Progress towards structural understanding of infectious sheep PrP-amyloid
2014
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Evidence for Initial Non-specific Polypeptide Chain Collapse During the Refolding of the SH3 Domain of PI3 Kinase
2010
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Theory of protein folding
2004 Standout
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
The Structure of Amyloid Fibrils by Electron Microscopy and X-Ray Diffraction
1997
Hydrogen exchange mass spectrometry for studying protein structure and dynamics
2010
Amide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
2013
Structure and stability of the molten globule state of guinea pig .alpha.-lactalbumin: A hydrogen exchange study
1993
Specific Nucleus as the Transition State for Protein Folding: Evidence from the Lattice Model
1994
The chaperonin GroEL binds a polypeptide in an .alpha.-helical conformation
1991
KINETIC STUDY OF THE HELIX TO COIL DARK REACTION OF POLY(SPIROPYRAN‐l‐GLUTAMATE)*
1992
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
2010
The Parallel Superpleated Beta-structure as a Model for Amyloid Fibrils of Human Amylin
2005
How do small single-domain proteins fold?
1998
The Amyloid State of Proteins in Human Diseases
2012 Standout
A Diversity of Assembly Mechanisms of a Generic Amyloid Fold
2011
Impact energy measurement in time-of-flight mass spectrometry with cryogenic microcalorimeters
1998 StandoutNatureNobel
Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches
2008
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Estimating the Prevalence of Protein Sequences Adopting Functional Enzyme Folds
2004
Identification and Characterization of a Novel Molecular-recognition and Self-assembly Domain within the Islet Amyloid Polypeptide
2002
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Amyloid Fibril Formation Can Proceed from Different Conformations of a Partially Unfolded Protein
2005
Principles of protein folding, misfolding and aggregation
2004
A surprising simplicity to protein folding
2000 StandoutNatureNobel
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme
2016
Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin
2001
Amyloid formation by globular proteins under native conditions
2008
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
2016
Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct
2007
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
2009 Standout
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments
1993
Protein folding dynamics: The diffusion‐collision model and experimental data
1994
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy
2000
Uncoupling retro‐translocation and degradation in the ER‐associated degradation of a soluble protein
2004
Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation
2010
Binding Site Detection and Druggability Index from First Principles
2009
Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant
2000 Science
Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins
1999 Science
Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
2015
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
1997 StandoutNobel
Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the β-domain
2000
Supramolecular Polymerization
2009 Standout
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences
2008 Standout
Regional mapping of prion proteins in brain.
1992 StandoutNobel
Pathogenesis, diagnosis and treatment of systemic amyloidosis
2001
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution
2010
The emergence of mass spectrometry in biochemical research.
1994
Chiroptical Molecular Switches
2000 StandoutNobel
Helix−Coil Kinetics: Folding Time Scales for Helical Peptides from a Sequential Kinetic Model
1996
NMR Determination of Residual Structure in a Urea-Denatured Protein, the 434-Repressor
1992 StandoutScienceNobel
Native protein sequences are close to optimal for their structures
2000 StandoutNobel
Insight into the Mechanisms of Cooperative Self-Assembly: The “Sergeants-and-Soldiers” Principle of Chiral and Achiral C3-Symmetrical Discotic Triamides
2007
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Structure-Based Strategies for Drug Design and Discovery
1992 Science
Visualizing tmRNA Entry into a Stalled Ribosome
2003 StandoutScienceNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
2014
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Secondary Structure in the Core of Amyloid Fibrils Formed from Human β2m and its Truncated Variant ΔN6
2014
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
1997 StandoutNobel
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
An amyloid-forming segment of β2-microglobulin suggests a molecular model for the fibril
2004
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Chaperone rings in protein folding and degradation
1999
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
2013
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
2014
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Polyglutamine aggregation nucleation: Thermodynamics of a highly unfavorable protein folding reaction
2005
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant
2011
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Peptide Conformation and Supramolecular Organization in Amylin Fibrils: Constraints from Solid-State NMR
2007
Cooperative Interaction between the Three Strands of a Designed Antiparallel β-Sheet
1998
Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release
2005
Works of Andrew D. Miranker being referenced
Demonstration by NMR of folding domains in lysozyme
1991 StandoutNatureNobel
Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide
2009
Phospholipid Catalysis of Diabetic Amyloid Assembly
2004
A regulatable switch mediates self-association in an immunoglobulin fold
2008
A native to amyloidogenic transition regulated by a backbone trigger
2006
Functionality maps of binding sites: A multiple copy simultaneous search method
1991
Formation of a Stable Oligomer of β-2 Microglobulin Requires only Transient Encounter with Cu(II)
2006
Collapse and cooperativity in protein folding
1996
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
1999 Nature
Metal binding sheds light on mechanisms of amyloid assembly
2009
Direct detection of transient α‐helical states in islet amyloid polypeptide
2006
The Role of Prefibrillar Structures in the Assembly of a Peptide Amyloid
2009
Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid
2004
Synthetic α‐Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation
2009
Scope and utility of hydrogen exchange as a tool for mapping landscapes
2007
Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway 1 1Edited by F. Cohen
2001
Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry
2000
Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR
1997
Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation
2001
The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes
2009
Investigation of protein folding by mass spectrometry
1996
Conserved and Cooperative Assembly of Membrane-Bound α-Helical States of Islet Amyloid Polypeptide
2006
Protein-induced photophysical changes to the amyloid indicator dye thioflavin T
2010
Formation of a Copper Specific Binding Site in Non-Native States of β-2-Microglobulin
2002
Mechanistic Studies of the Folding of Human Lysozyme and the Origin of Amyloidogenic Behavior in Its Disease-Related Variants
1999
Oligomeric Assembly of Native-like Precursors Precedes Amyloid Formation by β-2 Microglobulin
2004
Isotope-Labeling Strategy for the Assignment of Protein Fragments Generated for Mass Spectrometry
1996
Cooperative Elements in Protein Folding Monitored by Electrospray Ionization Mass Spectrometry
1995
Detection of Transient Protein Folding Populations by Mass Spectrometry
1993 Science
Fiber-dependent amyloid formation as catalysis of an existing reaction pathway
2007
Islet Amyloid: Phase Partitioning and Secondary Nucleation Are Central to the Mechanism of Fibrillogenesis
2002