Standout Papers
Citation Impact
Citing Papers
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Saccharomyces cerevisiae cell cycle
1974 StandoutNobel
Proteomics of the lysosome
2008
Selective Uptake of Cytosolic, Peroxisomal, and Plasma Membrane Proteins into the Yeast Lysosome for Degradation
1996 StandoutNobel
Synaptophysin is sorted from endocytotic markers in neuroendocrine PC12 cells but not transfected fibroblasts
1991
The mechanism of receptor‐mediated endocytosis
1991
Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes
1988
Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases
2007
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Mechamisms of cell polarity: sorting and transport in epithelial cells
1994
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
Rab proteins and the road maps for intracellular transport
1993
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
1995
Synthesis and receptor binding affinity of carboxylate analogues of the mannose 6-phosphate recognition marker
2006
Isolation and characterization of osmosensitive vacuolar mutants of Saccharomyces cerevisiae
1991
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Lysosomal Biogenesis in Lysosomal Storage Disorders
1997
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Human Resident Langerhans Cells Display a Lysosomal compartment Enriched in MHC Class II
1994
Control of Protein Exit from the Endoplasmic Reticulum
1989
Biogenesis of the Vacuole in Saccharomyces cerevisiae
1992
Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes
1991
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Mannose 6-phosphate receptors: new twists in the tale
2003
Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum
1989
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
Selective inhibition of transcytosis by brefeldin A in MDCK cells
1991
Chapter 6 Protein Sorting in the Secretory Pathway
1985
β-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo
1993
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
1991 Nature
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
1993 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Clathrin, Adaptors, and Sorting
1990
Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent.
1987
Yeast secretory mutants that block the formation of active cell surface enzymes.
1984 StandoutNobel
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Structure, biosynthesis, and localization of dipeptidyl aminopeptidase B, an integral membrane glycoprotein of the yeast vacuole.
1989
Carbohydrate chains on yeast carboxypeptidase Y are phosphorylated.
1981
Three proteolytic systems in the yeast saccharomyces cerevisiae
1991
The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex
1986 Science
Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway
1986
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins.
1986
Roles of protein and carbohydrate in glycoprotein processing and secretion. Studies using mutants expressing altered IgM mu chains.
1981 StandoutNobel
PEP4 Gene of Saccharomyces cerevisiae Encodes Proteinase A, a Vacuolar Enzyme Required for Processing of Vacuolar Precursors
1986
Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
1983 StandoutNobel
Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.
1988
Application of cryoultramicrotomy to immunocytochemistry
1986
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.
1991
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
1986
The PEP4 Gene Encodes an Aspartyl Protease Implicated in the Posttranslational Regulation of Saccharomyces cerevisiae Vacuolar Hydrolases
1986
Mutations in PEP4 locus of Saccharomyces cerevisiae block final step in maturation of two vacuolar hydrolases.
1983
Recycling of proteins from the Golgi compartment to the ER in yeast.
1990
Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis.
1991
Immunoelectron microscopic localization of ubiquitin in hepatoma cells.
1988 StandoutNobel
Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution
1982
The BOS1 gene encodes an essential 27-kD putative membrane protein that is required for vesicular transport from the ER to the Golgi complex in yeast.
1991
Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells.
1985
Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization
1994 StandoutNobel
The differential degradation of two cytosolic proteins as a tool to monitor autophagy in hepatocytes by immunocytochemistry.
1993
Protein Sorting in Saccharomyces cerevisiae: Isolation of Mutants Defective in the Delivery and Processing of Multiple Vacuolar Hydrolases
1988
The fungal vacuole: composition, function, and biogenesis
1990
Chemical Glycobiology
2001 StandoutScienceNobel
Characterization of large oligosaccharide-lipids synthesized in vitro by microsomes from Saccharomyces cerevisiae.
1980
A Flexible Route to Mannose 6-Phosphonate Functionalized Derivatives
2002
Biological activities of the two major components of tunicamycin.
1979
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.
1997
Synthesis and processing of in vitro and in vivo precursors of the vacuolar yeast enzyme carboxypeptidase Y.
1981
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.
1988
Intracellular protein topogenesis
1980 StandoutNobel
Temperature-sensitive yeast mutants deficient in asparagine-linked glycosylation.
1982
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
PEP4 GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN SACCHAROMYCES CEREVISIAE
1982
Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.
1989
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
1992 StandoutNatureNobel
Membrane traffic in animal cells
1984 StandoutNobel
Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.
1986 StandoutNobel
Coated vesicles from rat liver and calf brain contain lysosomal enzymes bound to mannose 6-phosphate receptors.
1983
Catabolite inactivation of the galactose uptake system in yeast.
1977
Coated vesicles from rat liver and calf brain contain cryptic mannose 6-phosphate receptors.
1983
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.
1989 StandoutNobel
Accumulation of coated vesicles bearing mannose 6-phosphate receptors for lysosomal enzymes in the Golgi region of I-cell fibroblasts.
1984
Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole
1982 StandoutNobel
Synthesis and maturation of the yeast vacuolar enzymes carboxypeptidase Y and aminopeptidase I
1983
How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.
1994
Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease
1987
Genetic control of cell size at cell division in yeast
1975 StandoutNatureNobel
Endocytosis and the recycling of plasma membrane.
1983 StandoutNobel
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.
1992
Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.
1989 StandoutNobel
Localization of the thermosensitive X‐prolyl dipeptidyl aminopeptidase in the vacuolar membrane of Saccharomyces cerevisiae
1984
Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.
1986 StandoutNobel
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast
1981 StandoutNatureNobel
Processing and secretion of alpha-mannosidase forms by Dictyostelium discoideum.
1982
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
The secretory pathway in yeast
1982 StandoutNobel
Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex.
1994 StandoutNobel
Glycoprotein nature of yeast alkaline phosphatase. Formation of active enzyme in the presence of tunicamycin.
1979
Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo.
1989
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Function of glycoprotein glycans
1985
Xenopus oocytes can secrete bacterial β-lactamase
1984 Nature
A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.
1987 StandoutNobel
Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast.
1989
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
1986
The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.
1995
Pathways of Protein Secretion in Eukaryotes
1985 Science
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase.
1989
Compartmental organization of the golgi stack
1985
Mechanisms for the incorporation of proteins in membranes and organelles.
1982
The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution.
1992
Antibodies against lysosomal membranes reveal a 100,000-mol-wt protein that cross-reacts with purified H+,K+ ATPase from gastric mucosa.
1984
Isolation of yeast mutants defective in protein targeting to the vacuole.
1986
Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.
1981 StandoutNobel
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.
1993
INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS
1987
Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme.
1985 StandoutNobel
Steps in the Phosphorylation of the High Mannose Oligosaccharides of Lysosomal Enzymes
1982
Biogenesis of vacuolar membrane glycoproteins of yeast Saccharomyces cerevisiae.
1990 StandoutNobel
Inhibition of endocytosis by anti-clathrin antibodies
1987
Radioactive tracer techniques in the sequencing of glycoprotein oligosaccharides
1991
Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B.
1979
Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysis.
1989 StandoutNobel
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
The Phosphomannosyl Recognition System for Intracellular and Intercellular Transport of Lysosomal Enzymes
1982
In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent post-translational translocation of the prepro-α-factor
1986
Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.
1994
Brefeldin A: insights into the control of membrane traffic and organelle structure.
1992 Standout
Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis
1987
Chapter 7 Isolation of Vacuoles from Yeasts
1975
Vacuoles: The sole compartments of digestive enzymes in yeast (Saccharomyces cerevisiae)?
1979
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
Glycosylation and processing of prepro-α-factor through the yeast secretory pathway
1984 StandoutNobel
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting.
1991
Clathrin Requirement for Normal Growth of Yeast
1987 Science
The Golgi Apparatus: Two Organelles in Tandem
1981 Science
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting.
1988
Protein Localization and Membrane Traffic in Yeast
1985 StandoutNobel
Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.
1988 StandoutNobel
Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis
1997
Studies on the mechanisms of autophagy: formation of the autophagic vacuole.
1990
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
Synthesis of related forms of the lysosomal enzyme alpha-mannosidase in Dictyostelium discoideum.
1983
Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide
1987
The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence
1984
Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae.
1988 StandoutNobel
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast
1981 StandoutNobel
Glycoprotein synthesis in yeast. Identification of Man8GlcNAc2 as an essential intermediate in oligosaccharide processing.
1982
Works of Andrej Hasilík being referenced
Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation
1992
Integral and Associated Lysosomal Membrane Proteins
2007
46-kDa Mannose 6-phosphate-Specific Receptor: Purification, Subunit Composition, Chemical Modification
1987
46-kDa Mannose 6-phosphate-Specific Receptor: Biosynthesis, Processing, Subcellular Location and Topology
1987
Biosynthesis of the Vacuolar Yeast Glycoprotein Carboxypeptidase Y
1978
Carbohydrate-free carboxypeptidase Y is transferred into the lysosome-like yeast vacuole
1982
Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol
1985
Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus.
1982
Cathepsin D precursors in clathrin-coated organelles from human fibroblasts.
1985
Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase.
1981
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome
2009
Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?
1987
Myeloperoxidase is synthesized as larger phosphorylated precursor.
1984
Biosynthesis of lysosomal enzymes
1980
Ultrastructural localization of the mannose 6-phosphate receptor in rat liver.
1984
Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat liver
1984
Biosynthesis of carboxypeptidase Y in yeast. Evidence for a precursor form of the glycoprotein
1976
Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae.
1981
Genesis of lysosomal enzyme deficiencies
1984
Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis
1978
Transport and processing of lysosomal enzymes by smooth muscle cells and endothelial cells
1981
Biosynthesis and transport of cathepsin D in cultured human fibroblasts.
1983
Deficiency of UDP-N-acetylglucosamine: Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients
1982
UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.
1982
Participation of the tryptophan synthase inactivating system from yeast in the activation of chitin synthase
1973
Inhibition of the Apparent Rate of Synthesis of the Vacuolar Glycoprotein Carboxypeptidase Y and Its Protein Antigen by Tunicamycin in Saccharomyces cerevisiae
1976
Compartmentation of the Tryptophan‐Synthase‐Proteolyzing System in Saccharomyces cerevisiae
1974
Possible pathways for lysosomal enzyme delivery.
1985
Processing of human cathepsin D in lysosomes in vitro.
1985
Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes.
1981
Enzymatic phosphorylation of lysosomal enzymes in the presence of UDP-N-acetylglucosamine. Absence of the activity in l-cell fibroblasts
1981
Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues.
1980
Internalization of blocking antibodies against mannose-6-phosphate specific receptors.
1985
Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways.
1987
Phosphorylated oligosaccharides in lysosomal enzymes: identification of alpha-N-acetylglucosamine(1)phospho(6)mannose diester groups.
1980
Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.
1985
Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.
1980 Standout
Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts.
1984
Cathepsin D and beta-hexosaminidase synthesized in the presence of 1-deoxynojirimycin accumulate in the endoplasmic reticulum.
1984
LYSOSOMAL ENZYMES AND THEIR RECEPTORS
1986
Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes.
1987