Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis
2008 StandoutNobel
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
2008 Science
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
2011
Pten Loss Causes Hypertrophy and Increased Proliferation of Astrocytes In vivo
2004
Pten Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner
2006
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
2010
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration
2012
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
2011
Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
2012
Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
2009
MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex
2013
Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
2014
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
2014 Standout
Brawn for Brains: The Role of MEF2 Proteins in the Developing Nervous System
2005
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche
2012
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
2006 Standout
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
2006
S6k1 is not required for Pten-deficient neuronal hypertrophy
2006
Resolving the Controversy about N-Cadherin and Hematopoietic Stem Cells
2010
Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover
2010
Metabolic heterogeneity confers differences in melanoma metastatic potential
2019 Nature
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
2011 Standout
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
2007
MYC on the Path to Cancer
2012 Standout
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
2019
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
A role for c-Myc in the regulation of ribosomal RNA processing
2003
Applying the principles of stem-cell biology to cancer
2003
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
2007
Oncogene addiction
2004
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance
2010
N-Cadherin Expression Level Distinguishes Reserved versus Primed States of Hematopoietic Stem Cells
2008
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Developmental Context Determines Latency of MYC-Induced Tumorigenesis
2004
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
2006 Nature
Mesenchymal stem cells in health and disease
2008 Standout
Tenets of PTEN Tumor Suppression
2008
Origins of Metastatic Traits
2013
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
2012
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
The Interplay Between MYC and HIF in the Warburg Effect
2008
Growth and folding of the mammalian cerebral cortex: from molecules to malformations
2014
mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
2010
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
2003 Standout
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
2006 Nature
Metastasis prevention by targeting the dormant niche
2015
Mechanisms of disseminated cancer cell dormancy: an awakening field
2014
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
2013 Nature
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
2001
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Organoid culture systems for prostate epithelial and cancer tissue
2016
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
2005
SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors
2013
Tumor metastasis: moving new biological insights into the clinic
2013
Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow
2010
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
2015
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
2015
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
2011
Proteolytic Control of the Oncoprotein Transcription Factor Myc
2011
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
2010 Nature
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
2023
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network
2003
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
2011
Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation
2010
Max-independent functions of Myc in Drosophila melanogaster
2008
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
2010
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
The Cell Cycle and Myc Intersect with Mechanisms that Regulate Pluripotency and Reprogramming
2009
The c-Myc target gene network
2006
Genomic targets of the human c-Myc protein
2003
Ferreting out stem cells from their niches
2011
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
2005 Standout
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
2005
Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
2008
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation
2010
Uncertainty in the niches that maintain haematopoietic stem cells
2008
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
2011
Stems Cells and the Pathways to Aging and Cancer
2008
PTEN-deficient intestinal stem cells initiate intestinal polyposis
2007
MYC as a regulator of ribosome biogenesis and protein synthesis
2010
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
2003 Standout
Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
2010 Nature
Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival
2015
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Emerging Biological Principles of Metastasis
2017 Standout
"You Don't Muck with MYC"
2010
Hematopoietic Stem Cells Do Not Depend on N-Cadherin to Regulate Their Maintenance
2009
Endothelial and perivascular cells maintain haematopoietic stem cells
2012 Nature
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
2015
Hypoxic gene expression and metastasis
2004
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
2007
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
EMT: 2016
2016 Standout
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
2008 StandoutNobel
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice
2007
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle
2007
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
2007
Mesenchymal stem cells: a new strategy for immunosuppression?
2007
The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race
2009
The cancer stem cell: premises, promises and challenges
2011 Standout
Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch Development
2001
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
Modelling Myc inhibition as a cancer therapy
2008 Nature
Myc deletion rescues Apc deficiency in the small intestine
2007 Nature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis
2011
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
2003
Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
2007
Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78
2011
Non-transcriptional control of DNA replication by c-Myc
2007 Nature
Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors
2005
Tumor Spectrum, Tumor Latency and Tumor Incidence of the Pten-Deficient Mice
2007
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Neural progenitor genes
2003
PTEN function in mammalian cell size regulation
2002
Pten Regulates Neuronal Arborization and Social Interaction in Mice
2006
Endochondral ossification is required for haematopoietic stem-cell niche formation
2008 Nature
Transcriptional regulation and transformation by Myc proteins
2005
Immune cell promotion of metastasis
2015
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
2001
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
2008
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
2007
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
2014
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
2019 Nature
Hematopoietic Stem Cell Trafficking
2007
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1
2002
Lack of Evidence that Hematopoietic Stem Cells Depend on N-Cadherin-Mediated Adhesion to Osteoblasts for Their Maintenance
2007
Arteriolar niches maintain haematopoietic stem cell quiescence
2013 Nature
Chapter 2 DNA-PK
2008
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
2013
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling
2004
Malignant melanoma: genetics and therapeutics in the genomic era
2006
Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
2001
Novel c‐MYC target genes mediate differential effects on cell proliferation and migration
2006
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Pten signaling in gliomas
2002
The journey of developing hematopoietic stem cells
2006
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
2007
The landscape of metastatic progression patterns across major human cancers
2014
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones
2009
Conditional Deletion ofc-mycDoes Not Impair Liver Regeneration
2006
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
2011
Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells
2012
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
2011
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Targeted Biallelic Inactivation of Pten in the Mouse Prostate Leads to Prostate Cancer Accompanied by Increased Epithelial Cell Proliferation but not by Reduced Apoptosis
2005
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
2000 Standout
Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue
2005
Bone Marrow-Derived Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated from Healthy Donors and Systemic Lupus Erythematosus Patients
2007
Molecular characterization of melanocyte stem cells in their niche
2005
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
2002
AnFgf8mouse mutant phenocopies human 22q11 deletion syndrome
2002 StandoutNobel
Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche
2007
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression
2010
TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
2008
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
2012
PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization
2005
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1cell cycle entry
2005
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
2003
Metabolic reprogramming and cancer progression
2020 StandoutScience
Spontaneous Transformation of Cultured Mouse Bone Marrow–Derived Stromal Cells
2006 StandoutNobel
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
2005
Conservation of the Notch signalling pathway in mammalian neurogenesis
1997 StandoutNobel
Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.
1996
Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo
2006 StandoutNobel
FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands
1997
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
2006
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair
2018
C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine
2008
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes
2006
A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest
2006
cdc12p, a Protein Required for Cytokinesis in Fission Yeast, Is a Component of the Cell Division Ring and Interacts with Profilin
1997 StandoutNobel
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells
2012
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain
2002
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
2007
Cancerous stem cells can arise from pediatric brain tumors
2003 Standout
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
2002
Immunogenicity of Human Mesenchymal Stem Cells in HLA-Class I-Restricted T-Cell Responses Against Viral or Tumor-Associated Antigens
2008
Tracking adult stem cells
2011
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
2010
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
2010
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation
2004
CXCR4 is required for the quiescence of primitive hematopoietic cells
2008
The Predominant Neural Stem Cell Isolated from Postnatal and Adult Forebrain But Not Early Embryonic Forebrain Expresses GFAP
2003
Works of Andreas Trumpp being referenced
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo
2001 Science
Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells
2005
Haematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
2008
The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis.
1992
Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient Background
2005
Awakening dormant haematopoietic stem cells
2010
Neurotrophin–3 is required for proper cerebellar development
1999
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
2013
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
2011
Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin
2015
Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21 Cip1 gene
2006
Human haematopoietic stem cell lineage commitment is a continuous process
2017
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
2008
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
1999 Nobel
Estimating Dormant and Active Hematopoietic Stem Cell Kinetics through Extensive Modeling of Bromodeoxyuridine Label-Retaining Cell Dynamics
2009
Myc's other life: stem cells and beyond
2009
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
2007
More than just proliferation: Myc function in stem cells
2005
Targeting leukemic stem cells by breaking their dormancy
2010
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs
2022
c-Myc regulates mammalian body size by controlling cell number but not cell size
2001 NatureNobel
Mechanisms of Disease: cancer stem cells—targeting the evil twin
2008
Bone-marrow haematopoietic-stem-cell niches
2006
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
2004
Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity
2008
C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†
2008
IFNα activates dormant haematopoietic stem cells in vivo
2009 Nature
Balancing dormant and self-renewing hematopoietic stem cells
2009
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP‐mediated recombination in the mouse
2000 Nobel
DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
2001
The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
2011
Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
2007
Activated Src abrogates the Myc requirement for the G 0 /G 1 transition but not for the G 1 /S transition
2006
AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress
2018
Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System
2003
The evolving concept of cancer and metastasis stem cells
2012
c-Myc Is Required for the Formation of Intestinal Crypts but Dispensable for Homeostasis of the Adult Intestinal Epithelium
2005
Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients
2014