Standout Papers
Citation Impact
Citing Papers
TRPA1 acts as a cold sensor in vitro and in vivo
2009
TRP Channels as Potential Drug Targets
2017
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
2009
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Structure of TRPV1 channel revealed by electron cryomicroscopy
2008
Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314
2013
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain
2008 Science
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Molecular Determinants of Vanilloid Sensitivity in TRPV1
2004
Nociceptors: a phylogenetic view
2009
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Pain Genes
2008
Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1 Protein
2014
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Lessons from peppers and peppermint: the molecular logic of thermosensation
2003 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
2002
Voltage-clamp and current-clamp recordings from mammalian DRG neurons
2009
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice
2007
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
2002
Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression
2007
The diversity in the vanilloid (TRPV) receptor family of ion channels
2002
Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons
2002
Voltage-Gated Sodium Channels: Mutations, Channelopathies and Targets
2011
Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor
2002
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Mechanisms of sensory transduction in the skin
2007 Nature
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
2002
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
2010
Extracellular cap domain is an essential component of the TRPV1 gating mechanism
2021
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
2006
Unique temperature-activated neurons from pit viper thermosensors
2004
Phenotyping sensory nerve endings in vitro in the mouse
2009
More than cool: Promiscuous relationships of menthol and other sensory compounds
2006 StandoutNobel
Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2 R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine
2008
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
2004
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouse
2004
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
2005
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Structure–functional intimacies of transient receptor potential channels
2009
Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain
2010
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Thermoreceptors and thermosensitive afferents
2009
painless, a Drosophila Gene Essential for Nociception
2003
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel
2015
Localization of mechanosensitive channel TRPV4 in mouse skin
2003
Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension
2010
Biochemistry and pharmacology of endovanilloids
2007
Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses
2004
The high threshold mechanotransducer: A status report
2005
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
2007
Characterization of Acid-sensing Ion Channels in Dorsal Horn Neurons of Rat Spinal Cord
2004
Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels
2009
Receptor-targeting mechanisms of pain-causing toxins: How ow?
2012 StandoutNobel
Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild‐type and TRPV1–/– mice
2003
TRPV channels as temperature sensors
2003
TRPV1 Is Activated by Both Acidic and Basic pH
2009 StandoutNobel
Neuronal TRP channels: thermometers, pathfinders and life-savers
2008
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1
2002
Low‐threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin‐insensitive
2000
TRPA1 antagonists as potential analgesic drugs
2011
The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin
2005 StandoutNobel
Direct Phosphorylation of Capsaicin Receptor VR1 by Protein Kinase Cε and Identification of Two Target Serine Residues
2002
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
TRP channels as cellular sensors
2003 StandoutNature
The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception
2009
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1
2014
TRPA1 Contributes to Cold Hypersensitivity
2010 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
2001
Induction of vanilloid receptor channel activity by protein kinase C
2000 Nature
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling
2005
Two Interdependent TRPV Channel Subunits, Inactive and Nanchung, Mediate Hearing in Drosophila
2004
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4
2005
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide
2001
The putative role of vanilloid receptor‐like protein‐1 in mediating high threshold noxious heat‐sensitivity in rat cultured primary sensory neurons
2002
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
2001
Speed and Temperature Dependences of Mechanotransduction in Afferent Fibers Recorded From the Mouse Saphenous Nerve
2008
Uncoupling Proton Activation of Vanilloid Receptor TRPV1
2007
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic
2008
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation
2002
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
A transient receptor potential channel expressed in taste receptor cells
2002
Models and Mechanisms of Hyperalgesia and Allodynia
2009
Phosphoinositide regulation of TRPV1 revisited
2015
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
2001
Mechanosensation and pain
2004
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain
2006
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
2006
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury
2006
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels
2008 StandoutNobel
Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin
1999
Hydroxy‐α‐sanshool activates TRPV1 and TRPA1 in sensory neurons
2007
Intracellular Signaling in Primary Sensory Neurons and Persistent Pain
2008
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin
2001
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis
2005 StandoutNobel
Endovanilloids
2004
Pain TRPs
2005
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2
2008
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
2008
An N-terminal variant of Trpv1 channel is required for osmosensory transduction
2005
Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis
2004
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia
2004
TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat
2008
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
A TRPV family ion channel required for hearing in Drosophila
2003 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel
2012
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
2009
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
2005 StandoutNobel
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Nociceptors—Noxious Stimulus Detectors
2007
Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
2009
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
The changing sensitivity in the life of the nociceptor
1999
Current understanding of mammalian TRP homologues
2002
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
2002 Nature
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
2002
Critical Evaluation of the Colocalization Between Calcitonin Gene-Related Peptide, Substance P, Transient Receptor Potential Vanilloid Subfamily Type 1 Immunoreactivities, and Isolectin B4 Binding in Primary Afferent Neurons of the Rat and Mouse
2006
TRPV1 Acts as Proton Channel to Induce Acidification in Nociceptive Neurons
2004
Localization of the PIP2 Sensor of TRPV1 Ion Channels
2011
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
Overview of the innervation of the lung
2002
TRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
2008
DrosophilaPainless Is a Ca2+-Requiring Channel Activated by Noxious Heat
2008
Sensory determinants of thermal pain
2002
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
2011 StandoutNobel
Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia
2008
TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons
2009
Impaired Pressure Sensation in Mice Lacking TRPV4
2003
TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
2009 StandoutNobel
From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function
2014
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
2001
Contribution of TRPM8 Channels to Cold Transduction in Primary Sensory Neurons and Peripheral Nerve Terminals
2006
Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms
2009
Capsaicin Responses in Heat-Sensitive and Heat-Insensitive A-Fiber Nociceptors
2001
Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation
2001
TRP Channel Proteins and Signal Transduction
2002
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition
2007 StandoutNobel
Attenuated Cold Sensitivity in TRPM8 Null Mice
2007
PERMEATION AND SELECTIVITY OF TRP CHANNELS
2005
The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters
2001
Regulation of TRP Channels via Lipid Second Messengers
2003
Molecular and Cellular Limits to Somatosensory Specificity
2008
The TRP Superfamily of Cation Channels
2005
Response Properties of Mechanoreceptors and Nociceptors in Mouse Glabrous Skin: An In Vivo Study
2001
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
2001
TRP Channels and Pain
2013 StandoutNobel
The Complex and Intriguing Lives of PIP 2 with Ion Channels and Transporters
2001
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
2015
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons
2006
The Meissner Corpuscle Revised: A Multiafferented Mechanoreceptor with Nociceptor Immunochemical Properties
2001
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Hot Receptors in the Brain
2006
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
TRP ION CHANNELS AND TEMPERATURE SENSATION
2006 StandoutNobel
TRPA1: A Gatekeeper for Inflammation
2012
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
2001
Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia
2002
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
TRP Channels
2007 Standout
Molecular mechanisms of cancer pain
2002
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat
2000
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
2014
TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties
2019
Works of Andreas Leffler being referenced
Streptozotocin Stimulates the Ion Channel TRPA1 Directly
2015
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons
2008
Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia
2010
TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons
2017
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)
2012
TRPA1 and Substance P Mediate Colitis in Mice
2011
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
2007 Nature
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue
2005
A high‐threshold heat‐activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium
2007
The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6
2013
The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
2005
GDNF and NGF Reverse Changes in Repriming of TTX-Sensitive Na+ Currents Following Axotomy of Dorsal Root Ganglion Neurons
2002
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Activation of dissociated IB4 binding dorsal root ganglion (DRG) neurons by ATP and capsaicin (CAPS)
1998
Activation of TRPA1 by Membrane Permeable Local Anesthetics
2011