Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Complement drives Th17 cell differentiation and triggers autoimmune arthritis
2010 StandoutNobel
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
2009
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
2005 StandoutNobel
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection
2007 StandoutNobel
Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease
2009
A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells
2009
Listeria monocytogenes -Infected Human Peripheral Blood Mononuclear Cells Produce IL-1β, Depending on Listeriolysin O and NLRP3
2009
Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit
2002
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation
2011
Tumour escape from immune surveillance through dendritic cell inactivation
2002
Complement, Age-Related Macular Degeneration and a Vision of the Future
2010
Manipulation of cell surface macromolecules by flaviviruses
2003
C5a receptor‐deficient dendritic cells promote induction of Treg and Th17 cells
2009
The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight
2007
The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction
2009
Complement and its role in innate and adaptive immune responses
2009 Standout
A view on drug resistance in cancer
2019 StandoutNature
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Modulation of the SDF-1–CXCR4 axis by the third complement component (C3)—Implications for trafficking of CXCR4+ stem cells
2006
Essential role for the second extracellular loop in C5a receptor activation
2005
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
2017
Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis
2013 Standout
A complex role for complement in allergic asthma
2010
The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function
1997
Complement: a unique innate immune sensor for danger signals
2004
Function, structure and therapeutic potential of complement C5a receptors
2007
Complement: coming full circle
2009
Comparison of procalcitonin and C-reactive protein as markers of sepsis
2003
Phagocyte Chemoattractant Receptors
1997
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
2013 Standout
Complement: a novel factor in basal and ischemia‐induced neurogenesis
2006
Complexity of complement activation in sepsis
2008
Complement anaphylatoxin receptors on neurons: new tricks for old receptors?
1999
Protective effects of C5a blockade in sepsis
1999
Fc Receptors and Their Role in Immune Regulation and Autoimmunity
2005
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Complement: a key system for immune surveillance and homeostasis
2010 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study
2007
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of Arrestins
2003 StandoutNobel
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Functional roles for C5a receptors in sepsis
2008
Functions of C5a receptors
2009
Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study
2006
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
The Clinical Value of Procalcitonin and Neopterin in Predicting Sepsis and Organ Failure After Major Trauma
2003
A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression
2001 StandoutNobel
Complement regulators and inhibitory proteins
2009
Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes
2010
Mast cell‐expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis
2006
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Adipokines and the Immune System: An Adipocentric View
2008
C-reactive protein: a valuable marker of sepsis
2002
The Classical Complement Cascade Mediates CNS Synapse Elimination
2007 Standout
Caspase-independent cell death
2005
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Taking Complement to the Clinic – has the Time Finally Come?
2009
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor
1996 StandoutNobel
Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
2007
Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics
2000
Display cloning: functional identification of natural product receptors using cDNA-phage display
1999
The Role of the N-terminal Domain of the Complement Fragment Receptor C5L2 in Ligand Binding
2006
Airway Mucus Function and Dysfunction
2010 Standout
The Pathophysiology and Treatment of Sepsis
2003 Standout
Mechanisms and Functions of Inflammasomes
2014 Standout
Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated Conformations of a G Protein‐Coupled Receptor
2002
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice
2006
Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo
1995
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis
2006
Assembly of the phagocyte NADPH oxidase
2004
ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains
1998
Life in the balance: how BH3-only proteins induce apoptosis
2005
Anaphylatoxins
2007
Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient?
2002
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
2006
A systems approach to infectious disease
2020
Crosstalk pathways between Toll-like receptors and the complement system
2010
Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis
2004 Standout
A crucial role for macrophages in the pathology of K/B × N serum‐induced arthritis
2005
Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome
2010
Mechanisms of effects of complement inhibition in murine collagen‐induced arthritis
2002
The dark side of C5a in sepsis
2004
Alternative Complement Pathway in Schizophrenia
2010
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
Modulation of the antitumor immune response by complement
2008
Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis
2001
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure
2005
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Kinase AKT1 Negatively Controls Neutrophil Recruitment and Function in Mice
2013
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
2000 StandoutNobel
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host
2009
The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
2012
Drusen complement components C3a and C5a promote choroidal neovascularization
2006
A Legionella pneumophila -translocated substrate that is required for growth within macrophages and protection from host cell death
2006
The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis
1998
Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri.
1993
Synthesis of Sulfotyrosine‐Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc‐Based Solid‐Phase Strategy
2015 StandoutNobel
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis
2001
Absence of the Complement Anaphylatoxin C3a Receptor Suppresses Th2 Effector Functions in a Murine Model of Pulmonary Allergy
2002
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Inhibition of Activation of the Classical Pathway of Complement by Human Neutrophil Defensins
1998
Diagnostic Efficacy and Prognostic Value of Serum Procalcitonin Concentration in Patients With Suspected Sepsis
2008
The Role of Histamine H1 and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study
2014
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Rheumatoid arthritis and the complement system
2007
Generation of C5a in the absence of C3: a new complement activation pathway
2006
Printing Proteins as Microarrays for High-Throughput Function Determination
2000 StandoutScience
Protective effects of anti‐C5a peptide antibodies in experimental sepsis
2001
Proteína C reactiva como marcador de infección en pacientes con traumatismo cerrado grave
2001
Opposing Regulatory Roles of Complement Factor 5 in the Development of Bleomycin-Induced Pulmonary Fibrosis
2005
Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
2007
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis
2010
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Inhibition of Activation of the Classical Pathway of Complement by Human Neutrophil Defensins
1998
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice
2005 StandoutNobel
Internalization of the HumanN-Formyl Peptide and C5a Chemoattractant Receptors Occurs via Clathrin-Independent Mechanisms
2001
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
A Novel C5a Receptor-Tissue Factor Cross-Talk in Neutrophils Links Innate Immunity to Coagulation Pathways
2006
Interruption of G Protein-Coupling in CXCR2 Does Not Alter Ligand Binding, but Eliminates Ligand-Activation of GTPγ35S Binding, Calcium Mobilization, and Chemotaxis
1997
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
2007 Standout
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR
2003 StandoutNobel
Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst 1
1993
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of Andreas Klos being referenced
Cutting Edge: Fc Receptor Type I for IgG on Macrophages and Complement Mediate the Inflammatory Response in Immune Complex Peritonitis
1999
The Phosphatidylinositol 3-Kinase Signaling Pathway Exerts Protective Effects during Sepsis by Controlling C5a-Mediated Activation of Innate Immune Functions
2007
Site‐specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor
1994
The C terminus of the human C5a receptor (CD88) is required for normal ligand‐dependent receptor internalization
1997
Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cells
1996
A selection system to study C5a–C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5aAla27
1997
Amino acids 327–350 of the human C5a‐receptor are not essential for [125I]C5a binding in COS cells and signal transduction in Xenopus oocytes
1994
Site‐Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor
1996
Circulating complement proteins in multiple trauma patients-Correlation with injury severity, development of sepsis, and outcome
1997
Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis
1996
C5L2 – an Anti-inflammatory Molecule or a Receptor for Acylation Stimulating Protein (C3a-desArg)?
2007
Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a
1993
Ligand Specificity of the Anaphylatoxin C5L2 Receptor and Its Regulation on Myeloid and Epithelial Cell Lines
2006
The human complement fragment receptor, C5L2, is a recycling decoy receptor
2008
Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88)
1999
C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding
1992
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6
2000
Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection
2018
C5a Mutants Are Potent Antagonists of the C5a Receptor (CD88) and of C5L2
2003
Synthetic peptides as antagonists of the anaphylatoxin C3a
1992
Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor
2013
The role of the anaphylatoxins in health and disease
2009
Functional expression of a human C5a receptor clone in Xenopus oocytes requires additional RNA
1991
Interaction Between the Coagulation and Complement System
2008
Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a
1999
C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis
2004
Gα‐16 complements the signal transduction cascade of chemotactic receptors for complement factor C5a (C5a‐R) and N‐formylated peptides (fMLF‐R) in Xenopus laevis oocytes: Gα‐16 couples to chemotactic receptors in Xenopus oocytes
1995
Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome
1996
Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models
2001
Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.
1998
IFN-γ up-regulates the human C5a receptor (CD88) in myeloblastic U937 cells and related cell lines
1995
Cutting Edge: Human Anaphylatoxin C4a Is a Potent Agonist of the Guinea Pig But Not the Human C3a Receptor,
1998
Differential regulation of the C3a and C5a receptors (CD88) by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines.
1996
Pathogen-driven CCR5/C5aR heterodimerization initiates a JNK2/JIP1-dependent signaling pathway that protects from Toxoplasma gondii infection
2008
The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes
1997
Cutting Edge: Guinea Pigs with a Natural C3a-Receptor Defect Exhibit Decreased Bronchoconstriction in Allergic Airway Disease: Evidence for an Involvement of the C3a Anaphylatoxin in the Pathogenesis of Asthma
2000
Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins
2004
Selection of a C5a Receptor Antagonist from Phage Libraries Attenuating the Inflammatory Response in Immune Complex Disease and Ischemia/Reperfusion Injury
1999
Nonhematopoietic Cells Control the Outcome of Infection withListeria monocytogenesin a Nucleotide Oligomerization Domain 1-Dependent Manner
2009