Standout Papers
Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
2005
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
2004
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Mitotic and mitogenic Wnt signalling
2012
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses
2016
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
2001 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
2010
A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration
2006
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
2013
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB
2002
T-Brain-1: A homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex
1995
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
1999
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP
1999
Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development
2012
β-catenin: a key mediator of Wnt signaling
1998
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
RNA Binding-independent Dimerization of Adenosine Deaminases Acting on RNA and Dominant Negative Effects of Nonfunctional Subunits on Dimer Functions
2007
Peripheral NT3 Signaling Is Required for ETS Protein Expression and Central Patterning of Proprioceptive Sensory Afferents
2003
Early stages of chick somite development
1995
Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation
1996 StandoutNobel
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Roles of Axin in the Wnt Signalling Pathway
1999
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p
1997
A common human skin tumour is caused by activating mutations in β-catenin
1999
Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
1998
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
2004 Nobel
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Identification of Maxillary Factor, a Maxillary Process–Derived Chemoattractant for Developing Trigeminal Sensory Axons
1999
A Combined Analysis of Genomic and Primary Protein Structure Defines the Phylogenetic Relationship of New Members of the T-Box Family
1998 StandoutNobel
Crystal Structure of Glycogen Synthase Kinase 3β
2001
Regulation of β-Catenin Signaling in the Wnt Pathway
2000
Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases
2009
Development of Sensory Neurons in the Absence of NGF/TrkA Signaling In Vivo
2000
The T-box gene family
1998
Molecular motors
2003 Nature
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1996 StandoutNature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis
1998
Predicting sites of ADAR editing in double-stranded RNA
2011
A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression
1999
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
2008
The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
2014
Making or Breaking the Heart: From Lineage Determination to Morphogenesis
2006
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
1994
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways
1997
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
A myocardial lineage derives from Tbx18 epicardial cells
2008 StandoutNature
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
Wnt/β-Catenin Signaling and Disease
2012 Standout
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
1993
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
2016
Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling
2000
Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex
1999
Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
2009
The establishment of spemann's organizer and patterning of the vertebrate embryo
2000
Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
2007
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
2015
Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos
2005
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
1998
Electrically driven directional motion of a four-wheeled molecule on a metal surface
2011 StandoutNatureNobel
The Type II Activin Receptors Are Essential for Egg Cylinder Growth, Gastrulation, and Rostral Head Development in Mice
1999
Armadillo and dTCF: a marriage made in the nucleus
1997 Standout
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
2006
The Yin-Yang of TCF/β-Catenin Signaling
1999
Control of β-Catenin Stability
2000
Building the mammalian heart from two sources of myocardial cells
2005
Derivation of pluripotent epiblast stem cells from mammalian embryos
2007 StandoutNature
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
1994 Standout
Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System
2012
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
2004 StandoutNobel
Expression Pattern of Wnt Signaling Components in the Adult Intestine
2005
Maintenance of somite borders in mice requires the Delta homologue Dll1
1997 Nature
AWNT4Mutation Associated with Müllerian-Duct Regression and Virilization in a 46,XX Woman
2004
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Tuning of RNA editing by ADAR is required in Drosophila
2005
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
1998 Standout
Probing the canonicity of the Wnt/Wingless signaling pathway
2017
Characterization and Expression Pattern of thefrizzledGeneFzd9,the Mouse Homolog ofFZD9Which Is Deleted in Williams–Beuren Syndrome
1999
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
1994
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
1999
Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
1994
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
2005
Mesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity
2003
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family
2004
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways
1999
Nascent-Seq Indicates Widespread Cotranscriptional RNA Editing in Drosophila
2012 StandoutNobel
T-box genes: what they do and how they do it
1999
Mouse gastrulation: the formation of a mammalian body plan
1997
Wnt signaling: why is everything so negative?
1998
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
1998 StandoutNature
Activation and Repression of Wingless/Wnt Target Genes by the TCF/LEF-1 Family of Transcription Factors
1999
Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
1998
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR
2009
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
1999
Markers of vertebrate mesoderm induction
1997 StandoutNobel
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
2015 Nature
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
2015
Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase
1997
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
1999 Nature
Pax genes in development
1994
β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
2002 Standout
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
2002
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
1999
Functions and Regulation of RNA Editing by ADAR Deaminases
2010
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
2013
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
1999
Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse
1998
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein
1998
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein
1998
Neurotrophins: Roles in Neuronal Development and Function
2001 Standout
Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase
1997 Science
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
2008
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
2002
Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis
1998
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
1998
The role of Pax-1 in axial skeleton development
1994
The future of cloning
1999 StandoutNatureNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Wnt signaling and cancer
2000 Standout
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
2002
Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression
2008
Molecular Structure and Physiological Function of Chloride Channels
2002
Judging a Protein by More Than Its Name: GSK-3
2001
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
2005
Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β
1998 Science
β-catenin signaling can initiate feather bud development
1999
Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
1996
Wnt signaling orients the proximal-distal axis of kidney nephrons
2015
Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ
2001
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Nodal signaling patterns the organizer
2000
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
2015 Science
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation
1996 StandoutNobel
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
2000
Overexpression of β-Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators
2000
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
2006
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
2005
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
2005
Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
1998
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
2005
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
2000
Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome
2004
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
1999
Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System
1997
Inhibition of β-catenin-mediated transactivation by cadherin derivatives
1998
A Molecular Elevator
2004 StandoutScienceNobel
Regulation of S33/S37 phosphorylated β-catenin in normal and transformed cells
2002
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.
1994
Conservation of Brachyury (T) genes in amphioxus and vertebrates: developmental and evolutionary implications
1995
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo
2000 StandoutNobel
The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation
1995
Mesoderm-inducing factors in early vertebrate development.
1993
Morphogen gradient interpretation
2001 StandoutNatureNobel
Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.
1994
Works of Andreas Kispert being referenced
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
2003
Cloning and expression analysis of the mouse T-box gene Tbx20
2001
Immunohistochemical Analysis of the Brachyury Protein in Wild-Type and Mutant Mouse Embryos
1994
Expression patterns of Wnt genes in mouse gut development
2001
The Chick Brachyury Gene: Developmental Expression Pattern and Response to Axial Induction by Localized Activin
1995
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left–right asymmetry
2002
Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
2006
β-catenin is a target for the ubiquitin–proteasome pathway
1997 Standout
Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b
2013
Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1
2004
Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation†
2008
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
2004
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
2001
Brachyury is a target gene of the Wnt/β-catenin signaling pathway
2000
Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells
2001
Mechanisms of T-box gene function in the developing heart
2011
The prepattern transcription factor Irx3 directs nephron segment identity
2007
Cloning and expression analysis of the mouse T-box gene Tbx18
2001
Female development in mammals is regulated by Wnt-4 signalling
1999 Nature
The T genes in embryogenesis
1994
The T-box transcription factor Tbx15 is required for skeletal development
2004
Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors
1999 StandoutScienceNobel
Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta.
1994
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
1998
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
1996
The T protein encoded by Brachyury is a tissue-specific transcription factor.
1995
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
1994
Tbx20is essential for cardiac chamber differentiation and repression ofTbx2
2005
A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae
1993
Sipl1 and Rbck1 Are Novel Eya1-Binding Proteins with a Role in Craniofacial Development
2010
The Brachyury gene encodes a novel DNA binding protein.
1993
The Brachyury gene encodes a novel DNA binding protein.
1993
Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development
2003
The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column
2000
Formation of the Venous Pole of the Heart From an Nkx2–5 –Negative Precursor Population Requires Tbx18
2006
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
2000
Rescue of the tail defect of Brachyury mice.
1993