Citation Impact
Citing Papers
Est1p As a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase
2002 Science
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance
1996
The effects of clozapine on the GSK‐3‐mediated signaling pathway
2004
The Dynamics of Yeast Telomeres and Silencing Proteins through the Cell Cycle
2000
Hallmarks of Cancer: The Next Generation
2011 Standout
Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
2012
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Chromatin Remodeling and the Control of Gene Expression
1997
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast
1994 Nature
Cohabitation of insulators and silencing elements in yeast subtelomeric regions
1999
Chromatin remodeling: a marriage between two families?
1998
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms
2003
Yeast Heterochromatin: Regulation of Its Assembly and Inheritance by Histones
1998
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association
2001
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Role of histone tails in nucleosome remodeling by Drosophila NURF
1997
Telomere looping permits gene activation by a downstream UAS in yeast
2001 Nature
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Chromatin disruption and modification
1999
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation
1996
Conspiracy of silence among repeated transgenes
1998
The Mediator complex: a central integrator of transcription
2015
Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast
1999
A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme
1999
Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae
2000
The language of covalent histone modifications
2000 StandoutNature
Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase
1997
Telomere states and cell fates
2000 StandoutNatureNobel
Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter
1999
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
2001 StandoutNatureNobel
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
1999 StandoutNobel
A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae
1996
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
2000 StandoutNobel
Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
1998
Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family
1999
Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter
1999
Crystal structure of the nucleosome core particle at 2.8 Å resolution
1997 StandoutNature
Mis6, a Fission Yeast Inner Centromere Protein, Acts during G1/S and Forms Specialized Chromatin Required for Equal Segregation
1997
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex
1998
Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs
1997
Telomerase modulates Wnt signalling by association with target gene chromatin
2009 Nature
Position and orientation of the globular domain of linker histone H5 on the nucleosome
1998 StandoutNatureNobel
The set1Δ mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes
2001
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Telomeres Do D-Loop–T-Loop
1999 StandoutNobel
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
1999
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
1999
The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA
2000
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing
1999
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails
2001
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily
1990 StandoutNobel
MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks
1999
Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system
2000 StandoutNobel
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
An Evolutionarily Conserved Mediator of Plant Disease Resistance Gene Function Is Required for Normal Arabidopsis Development
2002
Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States
2004
Polycombing the Genome: PcG, trxG, and Chromatin Silencing
1998
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
1997
Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA
2002
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
2000 StandoutNature
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
1997 Standout
Switching and Signaling at the Telomere
2001 StandoutNobel
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
2001
SET domain proteins modulate chromatin domains in eu- and heterochromatin
1998
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast
2001
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Histone acetylation in chromatin structure and transcription
1997 StandoutNature
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
1998
Locking in stable states of gene expression: transcriptional control during Drosophila development
1995
Signaling to Chromatin through Histone Modifications: How Clear Is the Signal?
1998
Telomeric chromatin modulates replication timing near chromosome ends
1999
Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative Senescence
2000
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
2001 StandoutNature
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Multivalent engagement of chromatin modifications by linked binding modules
2007
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Tel1p Preferentially Associates with Short Telomeres to Stimulate Their Elongation
2007
Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes
1999
Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation
1996
Histone acetylation and an epigenetic code
2000
A Subset of TAFIIs Are Integral Components of the SAGA Complex Required for Nucleosome Acetylation and Transcriptional Stimulation
1998
Gene regulation by steroid hormones
1989 Standout
The histone tails of the nucleosome
1998
The plant immune system
2006 StandoutNature
Irresistible force meets immovable object: Transcription and the nucleosome
1991 StandoutNobel
Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro
2000
ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
1999
Double Mutants of Saccharomyces cerevisiae with Alterations in Global Genome and Transcription-Coupled Repair
1996
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
The Establishment, Inheritance, and Function of Silenced Chromatin inSaccharomyces cerevisiae
2003
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.
1996
Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.
1996
Rap1 protein regulates telomere turnover in yeast
1998 StandoutNobel
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
1995
Repression and activation by multiprotein complexes that alter chromatin structure.
1996
The Biochemistry of Sirtuins
2006
Telomere Folding Is Required for the Stable Maintenance of Telomere Position Effects in Yeast
2000
Sir Proteins, Rif Proteins, and Cdc13p Bind Saccharomyces Telomeres In Vivo
1998
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
Hir Proteins Are Required for Position-Dependent Gene Silencing in Saccharomyces cerevisiae in the Absence of Chromatin Assembly Factor I
1998
Ku is associated with the telomere in mammals
1999 StandoutNobel
Wnt signaling and cancer
2000 Standout
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.
1997
Mutations in the fission yeast silencing factors clr4 + and rik1 + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function
1996
Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression
2000
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
1996
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
The formation and function of DNase I hypersensitive sites in the process of gene activation.
1988
The Drosophila Polycomb Protein Interacts with Nucleosomal Core Particles In Vitro via Its Repression Domain
1999
Histone Deacetylase: A Regulator of Transcription
1996 Science
An unusual form of transcriptional silencing in yeast ribosomal DNA.
1997
Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions
2004 StandoutNobel
A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
1997 Science
Telomeric Protein Distributions and Remodeling Through the Cell Cycle inSaccharomyces cerevisiae
2003 StandoutNobel
Structure and Function of the Core Histone N-Termini: More Than Meets the Eye
1998
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
1998
Functional domains for assembly of histones H3 and H4 into the chromatin of Xenopus embryos
1996
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae Telomeres Regulates Telomere Length
2004 StandoutNobel
Silent information regulator protein complexes in Saccharomyces cerevisiae : A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3
1997
An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres
1996 Science
A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
1996 Science
The Yeast Telomere Length Counting Machinery Is Sensitive to Sequences at the Telomere-Nontelomere Junction
1999
Chromatin and gene expression: Constant questions, but changing answers
1994
Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.
1995
Distinct protein interaction domains and protein spreading in a complex centromere
2000
STRUCTURE, FUNCTION, AND REPLICATION OF SACCHAROMYCES CEREVISIAE TELOMERES
1996
Characterization of the Wtm Proteins, a Novel Family ofSaccharomyces cerevisiaeTranscriptional Modulators with Roles in Meiotic Regulation and Silencing
1997 StandoutNobel
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing.
1995
Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae
1997
Functions of Site-Specific Histone Acetylation and Deacetylation
2007
In Vivo Analysis of Functional Regions within Yeast Rap1p
1999
RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo.
1997
Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern
1996
Cockayne syndrome group B protein enhances elongation by RNA polymerase II
1997 StandoutNobel
Works of Andreas Hecht being referenced
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
1995
Mediator Is a Transducer of Wnt/β-Catenin Signaling
2006
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets
2009
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
2000
Identification of a Promoter-specific Transcriptional Activation Domain at the C Terminus of the Wnt Effector Protein T-cell Factor 4
2003
Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro
1999
Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci
1991
Spreading of transcriptional represser SIR3 from telomeric heterochromatin
1996 Nature
Histones and the Regulation of Heterochromatin in Yeast
1993
Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction
1999
A progesterone responsive element maps to the far upstream steroid dependent DNase hypersensitive site of chicken lysozyme chromatin.
1988
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.
1997
The regulation of euchromatin and heterochromatin by histones in yeast
1995
Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1
1999
Curbing the nuclear activities of β‐catenin
2000