Standout Papers
Citation Impact
Citing Papers
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
2003
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
Mechanisms of Viral Membrane Fusion and Its Inhibition
2001
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine
1999
Imaging Ligand-Dependent Activation of CXCR7
2009
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
1988 StandoutNature
Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4
2009
Chemokines: immunology's high impact factors
2001
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
2006 Standout
Functional response of leukaemic blasts to stromal cell‐derived factor‐1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia
2000
The role of chemoattraction in cancer metastases
2001
Inflammation and cancer
2002 StandoutNature
The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice
2002
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
2013 Nature
D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes
2009
Downregulation of CXCR4 Gene Expression in Primary Human Endothelial Cells Following Infection with E1−E4+ Adenovirus Gene Transfer Vectors
2000
Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches
2011
Chemokines
2000 Standout
New insights on the role of CXCR4 in cancer metastasis
2008
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
2004
CXCR4/CXCL12 expression and signalling in kidney cancer
2002
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
2003
Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response
2000
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells
1999
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
The Earliest Stages of B Cell Development Require a Chemokine Stromal Cell-Derived Factor/Pre-B Cell Growth-Stimulating Factor
2001
Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1α: implications for development of selective CXCR4 antagonists
2001
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
2009 Standout
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
2007
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor
2003
Comparison of the structure of HLA-Bw47 to HLA-B13 and its relationship to 21-hydroxylase deficiency
1988
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Trafficking of the HIV Coreceptor CXCR4
1999
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
2004 Standout
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation
2002
Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny
2003
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
Membrane Fusion
2003 StandoutNobel
The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes
2005
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Embryonic Expression and Function of the Chemokine SDF-1 and Its Receptor, CXCR4
1999
Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer
2002
Ligand stabilization of CXCR4/δ‐opioid receptor heterodimers reveals a mechanism for immune response regulation
2008
Hypoxic gene expression and metastasis
2004
A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system☆☆Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under Accession Nos. AY182024 (human LRRTM1), AY182026 (human LRRTM2), AY182028 (human LRRTM3), AY182030 (human LRRTM4), AY182025 (mouse LRRTM1), AY182027 (mouse LRRTM2), AY182029 (mouse LRRTM3), and AY182031 (mouse LRRTM4).
2003
The stem-cell niche as an entity of action
2006 Nature
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
2003
Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
2000
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Control of Chemokine-Guided Cell Migration by Ligand Sequestration
2008
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription
1998
Revealing the world of RNA interference
2004 StandoutNatureNobel
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations
2012
Chemokine receptor CXCR4–dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
2005
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Cancer and the chemokine network
2004 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
The significance of cancer cell expression of the chemokine receptor CXCR4
2004
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
2002
Cancer-related inflammation
2008 StandoutNature
Identification of Residues of CXCR4 Critical for Human Immunodeficiency Virus Coreceptor and Chemokine Receptor Activities
2000
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma
2001
Chemokine receptors: multifaceted therapeutic targets
2002
Chemokines control fat accumulation and leptin secretion by cultured human adipocytes
2001
The Many Roles of Chemokines and Chemokine Receptors in Inflammation
2006 Standout
The Stromal Derived Factor–1/CXCL12–CXC Chemokine Receptor 4 Biological Axis in Non–Small Cell Lung Cancer Metastases
2003
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo
2003
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
2011 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
2009
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: Evolutionary aspects
1987
Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors
2000 Standout
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
2000 Standout
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Cell surface receptors, virus entry and tropism of primate lentiviruses
2002
CXCR4–SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
2002
CXC chemokines in angiogenesis
2000
Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression
2010
Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication
2002
A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma
2001
Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo
2008
A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo
2003
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4
1999 Science
Chemokine immunobiology in HIV-1 pathogenesis
1999
Stromal Cell–Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization
2003
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1α on CXCR4 Transmembrane Helical Domains
2005
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
2006
DNA sequence of HLA-A11: Remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells
1987
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
2003
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Chemokines and Cell Migration in Secondary Lymphoid Organs
1999 Science
Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.
2003
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells
2003
The chemokine SDF‐lα triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway
1999
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
2005
Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12
2008
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma.
2002
Mechanism by which the lectin actinohivin blocks HIV infection of target cells
2009 StandoutNobel
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.
2000
Age Decreases Endothelial Progenitor Cell Recruitment Through Decreases in Hypoxia-Inducible Factor 1α Stabilization During Ischemia
2007
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Expression of Functional CXCR4 by Muscle Satellite Cells and Secretion of SDF-1 by Muscle-Derived Fibroblasts is Associated with the Presence of Both Muscle Progenitors in Bone Marrow and Hematopoietic Stem/Progenitor Cells in Muscles
2003
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
1998 Standout
The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
2010
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions
1999
Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
2001 StandoutNobel
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
2007
CXCR4 is required for the quiescence of primitive hematopoietic cells
2008
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells
1999
Works of Andreas H. Kottmann being referenced
Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
2002
A survey of protein‐DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ52 element
1992 Nobel
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum
2004
A second promoter and enhancer element within the immunoglobulin heavy chain locus
1994 Nobel
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
1998 StandoutNature
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
2004
DNA sequence of the coding region of the HLA-B44 gene
1986