Citation Impact
Citing Papers
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
2015 Science
Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation
2016
Histone sumoylation is associated with transcriptional repression
2003
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism
2017 Science
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
2004
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
2007 StandoutScience
Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity
2009 Science
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
2018 StandoutNobel
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
2013
PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress
2006
PIAS proteins: pleiotropic interactors associated with SUMO
2009
Transcriptional Regulation and Its Misregulation in Disease
2013
Serum response factor is modulated by the SUMO-1 conjugation system
2003
Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4
2003
The Crystal Structure of Atg3, an Autophagy-related Ubiquitin Carrier Protein (E2) Enzyme that Mediates Atg8 Lipidation
2007 StandoutNobel
PIDD Mediates NF-κB Activation in Response to DNA Damage
2005
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling
2003
Topors acts as a SUMO‐1 E3 ligase for p53 in vitro and in vivo
2005
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
2007
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
2007
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways
2007
Regulated SUMOylation and Ubiquitination of DdMEK1 Is Required for Proper Chemotaxis
2002
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
2010 Standout
Ubc9 is required for damage-tolerance and damage-induced interchromosomal homologous recombination in S. cerevisiae
2004
The Polycomb Protein Pc2 Is a SUMO E3
2003
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci
2003
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
1997 Standout
Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
2011 StandoutNobel
An Improved Model for the hTERT Promoter Quadruplex
2014
A Lack of SUMO Conjugation Affects cNLS-dependent Nuclear Protein Import in Yeast
2002
Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer
2015
Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p
1997 StandoutNobel
The SUMO Isopeptidase Ulp2 Prevents Accumulation of SUMO Chains in Yeast
2003
Shared Principles in NF-κB Signaling
2008 Standout
Cross-talk between nuclear receptors and nuclear factor κB
2006
Loss of Net as Repressor Leads to Constitutive Increased c-fos Transcription in Cervical Cancer Cells
2004 StandoutNobel
SUMO Promotes HDAC-Mediated Transcriptional Repression
2004
Phosphorylation-Dependent Control of Pc2 SUMO E3 Ligase Activity by Its Substrate Protein HIPK2
2006
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
2015 Nobel
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
1997 StandoutNature
A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity
2010
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres
2016 Nobel
Nitric Oxide Destabilizes Pias3 and Regulates Sumoylation
2007
Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis
2004
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
Smt3/SUMO and Ubc9 are required for efficient APC/C‐mediated proteolysis in budding yeast
2004
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
2015
Identification of a Substrate Recognition Site on Ubc9
2002
Immunogenic cell death in cancer and infectious disease
2016 Standout
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
2003
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
2015 Standout
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients
2012
The Inhibitory Function in Human Progesterone Receptor N Termini Binds SUMO-1 Protein to Regulate Autoinhibition and Transrepression
2002
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
2013
Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes
2006
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types
2014
Modification in reverse: the SUMO proteases
2007
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
2008 StandoutNature
Peering through the Pore
2003
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins
2002
SUMO
2005 Standout
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
2002
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Missing Pieces in the NF-κB Puzzle
2002 Standout
Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity
2003
Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα
2008
A superfamily of protein tags: ubiquitin, SUMO and related modifiers
2003
Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation
2002
SUMO: ligases, isopeptidases and nuclear pores
2003
Transcription factor Sp3 is silenced through SUMO modification by PIAS1
2002
Genetic dissection of glucocorticoid receptor function in mice
1998
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
Genetic profiling of hepatocellular carcinoma using next-generation sequencing
2016
Regulation of Smad4 Sumoylation and Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT1
2004
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
2004
Identification of direct transcriptional targets of V600EBRAF/MEK signalling in melanoma
2009
Deep learning and process understanding for data-driven Earth system science
2019 StandoutNature
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
TGFβ in Cancer
2008 Standout
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Systematic interrogation of human promoters
2019
Genome-wide analysis of noncoding regulatory mutations in cancer
2014
SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling
2002
Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex
2005 Nature
Phospho-Regulated SUMO Interaction Modules Connect the SUMO System to CK2 Signaling
2009
Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway
2006
Role of the Glucocorticoid Receptor for Regulation of Hypoxia-dependent Gene Expression
2003
Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25
2008
Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis
2015
p300 Transcriptional Repression Is Mediated by SUMO Modification
2003
Nuclear and unclear functions of SUMO
2003
Steroid hormone receptors: Many Actors in search of a plot
1995 Standout
SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization
2002
Association of the Human SUMO-1 Protease SENP2 with the Nuclear Pore
2002
PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
2006
A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3
2003
Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis
1996
Computation of Conformational Coupling in Allosteric Proteins
2009 StandoutNobel
Ubc9 Sumoylation Regulates SUMO Target Discrimination
2008
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
An extended consensus motif enhances the specificity of substrate modification by SUMO
2006
SUMO modification of the ubiquitin-conjugating enzyme E2-25K
2005
Cancer-related inflammation
2008 StandoutNature
Structure of a SUMO-binding-motif Mimic Bound to Smt3p–Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein–E2 Complex as a Platform for Selective Interactions within a SUMO Pathway
2007
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Sumoylation of Mdm2 by Protein Inhibitor of Activated STAT (PIAS) and RanBP2 Enzymes
2002
Structure of the Siz/PIAS SUMO E3 Ligase Siz1 and Determinants Required for SUMO Modification of PCNA
2009
Ubc9 Is Essential for Viability of Higher Eukaryotic Cells
2002
Concepts in sumoylation: a decade on
2007
Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
2018
FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer
2014
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
2004
Autophagy-related Protein 8 (Atg8) Family Interacting Motif in Atg3 Mediates the Atg3-Atg8 Interaction and Is Crucial for the Cytoplasm-to-Vacuole Targeting Pathway
2010 StandoutNobel
Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1
2009
Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor
1996
Multiple activities contribute to Pc2 E3 function
2004
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
2004
SUMO-1/Ubc9 Promotes Nuclear Accumulation and Metabolic Stability of Tumor Suppressor Smad4
2003
Transcriptional Activity of CCAAT/Enhancer-binding Proteins Is Controlled by a Conserved Inhibitory Domain That Is a Target for Sumoylation
2002
A Proteomic Study of SUMO-2 Target Proteins
2004
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin
2002
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor
2003
Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex
2002
Hepatocellular Carcinoma
2019 Standout
Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus
1995
Sumoylation dynamics during keratinocyte differentiation
2006
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: A proteomic analysis
2004
Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1
2003
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
2003
Nse2, a Component of the Smc5-6 Complex, Is a SUMO Ligase Required for the Response to DNA Damage
2004
Proteomic analysis of the mammalian nuclear pore complex
2002
SUMO-1 Modification of PIASy, an E3 Ligase, Is Necessary for PIASy-Dependent Activation of Tcf-4
2005
Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation
2005
RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.
1995
An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved ψKXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity
2007
Spermidine in health and disease
2018 StandoutScience
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications
2005
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
1995
Structure, dynamics and function of nuclear pore complexes
2008
An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations
2015
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*
2000 Standout
Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ
1995
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
2003
Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling
2000 StandoutScience
SUMO Modification of Heterogeneous Nuclear Ribonucleoproteins
2004
Cancer Genome Landscapes
2013 StandoutScience
Brain Corticosteroid Receptor Balance in Health and Disease*
1998 Standout
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells
2015
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis
2003
Modification with SUMO
2003
Protein Modification by SUMO
2004 Standout
The SUMO E3 Ligase Activity of Pc2 Is Coordinated through a SUMO Interaction Motif
2010
Repression of Smad4 transcriptional activity by SUMO modification
2004
The nuclear pore component Nup358 promotes transportin-dependent nuclear import
2009
Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import
2020
Understanding TERT Promoter Mutations: A Common Path to Immortality
2016
The Influence of Social Hierarchy on Primate Health
2005 StandoutScience
Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor
2002
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Therapeutic Targeting of Telomerase
2016
Cancer-associated TERT promoter mutations abrogate telomerase silencing
2015
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia
2003
Works of Andreas Gast being referenced
TERT Promoter Mutations in Familial and Sporadic Melanoma
2013 Science
Opposed Regulation of Corepressor CtBP by SUMOylation and PDZ Binding
2003
Association of Inherited Variation in Toll-Like Receptor Genes with Malignant Melanoma Susceptibility and Survival
2011
B-RAF and N-RAS Mutations Are Preserved during Short Time In Vitro Propagation and Differentially Impact Prognosis
2007
Differential gene expression in melanocytic nevi with the V600E BRAF mutation
2007
The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity
2002
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
1994