Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
2003
Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Photoswitchable fatty acids enable optical control of TRPV1
2015
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
GPCR activation mechanisms across classes and macro/microscales
2021
Specificity of G Protein-Coupled Receptor Kinase 6-Mediated Phosphorylation and Regulation of Single-Cell M3 Muscarinic Acetylcholine Receptor Signaling
2003
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
2006
Homo- and Hetero-oligomerization of β-Arrestins in Living Cells
2005
Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
2006
The 5-Hydroxytryptamine(1A) Receptor Is Stably Palmitoylated, and Acylation Is Critical for Communication of Receptor with Gi Protein
2004
C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel
2010
Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor
2008
Constitutive Activity in Melanocortin-4 Receptor
2014
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
2003
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors
2004
Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein
2003
Probing cellular protein complexes using single-molecule pull-down
2011 Nature
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Analysis of receptor oligomerization by FRAP microscopy
2009
Dynamics of receptor/G protein coupling in living cells
2005
The in vivo chemistry of photoswitched tethered ligands
2014
A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein
2004
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
2015
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons
2015 Nature
Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2
2013
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells
2011
The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer
2003
Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
2008 Nobel
The circadian clock: pacemaker and tumour suppressor
2003
Polycystin-1 and -2 Dosage Regulates Pressure Sensing
2009
Structural basis of function in heterotrimeric G proteins
2006
GIPC Interacts with the β1-Adrenergic Receptor and Regulates β1-Adrenergic Receptor-mediated ERK Activation
2003 StandoutNobel
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms
2004
Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers
2009
Real-time monitoring of ubiquitination in living cells by BRET
2004
Oligomeric potential of the M2 muscarinic cholinergic receptor
2004
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
2012
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
C5a Receptor Oligomerization
2003
Kinetic Analysis of G Protein–Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
2007
The melanocortin receptors and their accessory proteins
2013
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Physiological roles of the melanocortin MC3 receptor
2011
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Methods to monitor the quaternary structure of G protein‐coupled receptors
2005
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
2009
An allosteric modulator to control endogenous G protein-coupled receptors with light
2014
Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting
2004
The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors
2004
Expression Profile of Ectopic Olfactory Receptors Determined by Deep Sequencing
2013
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Non-visual GRKs: are we seeing the whole picture?
2003
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells
2002
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
MC4R oligomerizes independently of extracellular cysteine residues
2005
G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?
2004
Melanocortin-4 receptor–regulated energy homeostasis
2016
Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
2010
Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET
2005
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
Recovery of Oligomers and Cooperativity When Monomers of the M2Muscarinic Cholinergic Receptor Are Reconstituted into Phospholipid Vesicles
2007
Roles of G‐protein‐coupled receptor dimerization
2004
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
2008 StandoutNobel
Oligomerization of G Protein-Coupled Receptors: Past, Present, and Future
2004
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
2009
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
G Protein–Coupled Receptor Oligomerization
2004
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Hypertension‐evoked RhoA activity in vascular smooth muscle cells requires RGS5
2017
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Complexes between photoactivated rhodopsin and transducin: progress and questions
2010
The evasive nature of drug efficacy: implications for drug discovery
2007
Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist
2003
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
Functional reconstitution of β2-adrenergic receptors utilizing self-assembling Nanodisc technology
2006
A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands
2017
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Artificial Molecular Machines
2015 Standout
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
2005
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
A Roadmap to Success in Photopharmacology
2015
Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia
2005
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
2010
Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment
2006
Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction
2007
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Emerging Targets in Photopharmacology
2016 StandoutNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Trafficking of G Protein–Coupled Receptors
2006 StandoutNobel
Membrane Trafficking of G Protein–Coupled Receptors
2004
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Andreas Breit being referenced
Determination of Bradykinin B2 Receptor in Vivo Phosphorylation Sites and Their Role in Receptor Function
2001
Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression
2016
The Natural Inverse Agonist Agouti-related Protein Induces Arrestin-mediated Endocytosis of Melanocortin-3 and -4 Receptors
2006
Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling
2010
Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
2002
Real-time monitoring of receptor and G-protein interactions in living cells
2005
Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist
2009
β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy
2002
Optical Control of TRPV1 Channels
2013
Hetero-oligomerization between β2- and β3-Adrenergic Receptors Generates a β-Adrenergic Signaling Unit with Distinct Functional Properties
2004
Pharmacology and Signaling of MAS-Related G Protein–Coupled Receptors
2014
Coupling of endothelin receptors to the ERK/MAP kinase pathway
2001
Expression of Tas1 Taste Receptors in Mammalian Spermatozoa: Functional Role of Tas1r1 in Regulating Basal Ca2+ and cAMP Concentrations in Spermatozoa
2012
Gq‐coupled receptors as mechanosensors mediating myogenic vasoconstriction
2008
Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis
2003
Optische Kontrolle von TRPV1‐Kanälen
2013