Standout Papers
- cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates (1992)
- Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo (1994)
- Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 (2002)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
A heterotrimeric death domain complex in Toll signaling
2002
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.
1993
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
In Vivo Regulation of the IκB Homologue cactus during the Immune Response of Drosophila
1998 StandoutNobel
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
1997
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
1998 Standout
Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
1999
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
2003
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
MicroRNAs
2004 Standout
A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity
2000
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
IκB-β regulates the persistent response in a biphasic activation of NF-κB
1995
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family
1996
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Interactions between the cellular and humoral immune responses in Drosophila
2000
Size Control in Animal Development
1999
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
1993 Nobel
Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo
2003 Nobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Phagocytosis of apoptotic cells in homeostasis
2015
Cellular survival: a play in three Akts
1999 Standout
Drosophila larval neuromuscular junction: Molecular components and mechanisms underlying synaptic plasticity
2000
The dorsal protein enhances the biosynthesis and stability of theDrosophilaIkB homologue cactus
1995
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Cell Death
2004 Standout
Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube
1999
Novel Features of Cryptochrome-Mediated Photoreception in the Brain Circadian Clock ofDrosophila
2004
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
NF-κB signaling pathways in mammalian and insect innate immunity
2001
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
1993
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers
2006
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
1999
Molecular genetics of Drosophila immunity
1994
MicroRNA Pathways in Flies and Worms
2003 StandoutNobel
The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers
1993
Cell Death in Development
1999
MyD88, an Adapter Protein Involved in Interleukin-1 Signaling
1998
Cactus-independent regulation of Dorsal nuclear import by the ventral signal
2000
Drosophila innate immunity: an evolutionary perspective
2002 StandoutNobel
The immune response of Drosophila
2003 StandoutNatureNobel
Weckle Is a Zinc Finger Adaptor of the Toll Pathway in Dorsoventral Patterning of the Drosophila Embryo
2006
Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning
2003
IAP proteins: blocking the road to death's door
2002
Induction and regulation of antimicrobial peptides in Drosophila
1999
Toll receptors in innate immunity
2001 StandoutNobel
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
2000
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
2002
Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis
2001 StandoutNobel
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient
2005
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Rsk1 mediates a MEK–MAP kinase cell survival signal
2000
Dif, a dorsal-related gene that mediates an immune response in Drosophila
1993
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The C. elegans Cell Death Specification Gene ces-1 Encodes a Snail Family Zinc Finger Protein
1999 StandoutNobel
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Dying like Flies
1998
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
2011
Dorsal-ventral polarity in the Drosophila embryo
1993
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
Regulated nuclear import of Rel proteins in the Drosophila immune response
1998 Nature
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004 StandoutNatureNobel
Cloning of a Differentially Expressed IκB-related Protein
1995
NF-κB: A lesson in family values
1995
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
1998
The functions of animal microRNAs
2004 StandoutNatureNobel
Ras1 Promotes Cellular Growth in the Drosophila Wing
2000
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Microglial Corpse Clearance: Lessons From Macrophages
2020
Regulation of death receptor signaling by the ubiquitin system
2009
Getting knotted: a model for the structure and activation of Spätzle
1998
Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.
1993
Epigenetic mechanisms in anti‐cancer actions of bioactive food components – the implications in cancer prevention
2012
Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression
1998
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
2002
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Toll-Like Receptors
2003 Standout
Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB
1995
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Cactus protein degradation mediates Drosophila dorsal-ventral signaling.
1995
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.
1993
Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.
1994
Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation
2001
Specificity of Rel-Inhibitor Interactions in Drosophila Embryos
1995
Role of MicroRNAs in Plant and Animal Development
2003 StandoutScienceNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.
1994
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
2002
The Drosophila Atypical Protein Kinase C-Ref(2)P Complex Constitutes a Conserved Module for Signaling in the Toll Pathway
2002
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
1994
Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans
1998
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
1993
The maternal NF-κB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle
2000
NF-κB and Rel Proteins in Innate Immunity
1995
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Drosophila MyD88 is an adapter in the Toll signaling pathway
2001
The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.
1995
A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis
1998
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling
1997 Science
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.
1996
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
1993
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
1998
IRAK: A Kinase Associated with the Interleukin-1 Receptor
1996 Science
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
1995 StandoutNobel
REL/NF-κB/IκB Story
1995
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
1997
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
A resetting signal between Drosophila pacemakers synchronizes morning and evening activity
2005 StandoutNatureNobel
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
A family of human receptors structurally related to Drosophila Toll
1998 Standout
DrosophilaWntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
2005
Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein.
1995
Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae.
1996
Related Target Enhancers for Dorsal and NF-κB Signaling Pathways
1994 Science
A pathway of signals regulating effector and initiator caspases in the developingDrosophilaeye
2002
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Autoregulation of I kappa B alpha activity.
1994
Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.
1994
BCL3 Encodes a Nuclear Protein Which Can Alter the Subcellular Location of NF-κB Proteins
1994
Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
1995
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.
1993
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs
1994
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.
1995
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal
1997
Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27
2012
Works of Andreas Bergmann being referenced
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila
2010
The CARD-carrying caspase Dronc is essential for most, but not all,developmental cell death in Drosophila
2005
The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila
2006
Survival Signaling Goes BAD
2002
The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling
1998
Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!
2008
Inactivation of Effector Caspases through Nondegradative Polyubiquitylation
2008
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
1996 Nobel
Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease
2017
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
Mechanisms and control of programmed cell death in invertebrates
1998
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
HIDden targets of microRNAs for growth control
2003
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
The protein kinase Pelle mediates feedback regulation in theDrosophilaToll signaling pathway
2001
When cells die
2000