Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
2004
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Mitotic and mitogenic Wnt signalling
2012
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.
2001
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
2001 Standout
Arresting a Transient Receptor Potential (TRP) Channel
2010 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Affinity mass spectrometry from a tailored porous silicon surfaceElectronic supplementary information (ESI) available: synthesis and characterization of new compounds, experimental details. See http://www.rsc.org/suppdata/cc/b4/b408200a/
2004
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
1999
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP
1999
β-catenin: a key mediator of Wnt signaling
1998
FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak
2001
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
2002
The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes
2006
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Roles of Axin in the Wnt Signalling Pathway
1999
TGF-β1-mediated alterations of renal proximal tubular epithelial cell phenotype
2003
Pygopus, a nuclear PHD-finger protein required for Wingless signaling inDrosophila
2002
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p
1997
A common human skin tumour is caused by activating mutations in β-catenin
1999
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
1998
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
2004 Nobel
Crystal Structure of Glycogen Synthase Kinase 3β
2001
Transcription under the Control of Nuclear Arm/β-Catenin
2006
Regulation of β-Catenin Signaling in the Wnt Pathway
2000
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis
1998
A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression
1999
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
2000
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
2012 Nature
Wnt signaling: a common theme in animal development
1997 Standout
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways
1997
Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry
2020 StandoutNobel
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
β-Catenin is a Nek2 substrate involved in centrosome separation
2007
Wnt/β-Catenin Signaling and Disease
2012 Standout
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
2016
Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling
2000
Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex
1999
Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
2009
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
2015
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
1998
Assessment of Patients' Competence to Consent to Treatment
2007 Standout
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Armadillo and dTCF: a marriage made in the nucleus
1997 Standout
The Yin-Yang of TCF/β-Catenin Signaling
1999
Control of β-Catenin Stability
2000
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex
2002
IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition
2001
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
2010 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
1998 Standout
Probing the canonicity of the Wnt/Wingless signaling pathway
2017
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
1999
DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT
2002
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
2005
Turn‐off, drop‐out: Functional state switching of cadherins
2002
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways
1999
Wnt signaling: why is everything so negative?
1998
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
1998 StandoutNature
Activation and Repression of Wingless/Wnt Target Genes by the TCF/LEF-1 Family of Transcription Factors
1999
Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
1998
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
1999
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase
1997
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
1999 Nature
β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
2002 Standout
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors
1999 StandoutScienceNobel
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
1999
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway
1999
Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing
2001
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
1999
H-Ras Activation Promotes Cytoplasmic Accumulation and Phosphoinositide 3-Oh Kinase Association of β-Catenin in Epidermal Keratinocytes
1999
Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse
1998
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein
1998
Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase
1997 Science
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis
1998
Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the β-Catenin Pathway
2001
Wnt signaling and cancer
2000 Standout
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
2002
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin
2000
Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression
2008
Judging a Protein by More Than Its Name: GSK-3
2001
β-Arrestins and Cell Signaling
2007 StandoutNobel
Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β
1998 Science
β-catenin signaling can initiate feather bud development
1999
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ
2001
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
Vertebrate Somitogenesis
2001
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
2000
Overexpression of β-Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators
2000
The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
1998
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
1998
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
2005
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
2000
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System
1997
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Inhibition of β-catenin-mediated transactivation by cadherin derivatives
1998
Regulation of S33/S37 phosphorylated β-catenin in normal and transformed cells
2002
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
1999
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Protein kinase CKII regulates the interaction of β-catenin withα-catenin and its protein stability
2002
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo
2000 StandoutNobel
Intercellular adhesion, signalling and the cytoskeleton
2002
Works of Andreas Bauer being referenced
Competence of mentally ill patients: a comparative empirical study
2003
Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells
1998
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
2015
Affinity purification‐mass spectrometry
2003
Regulation of Notch signalling by non-visual β-arrestin
2005
Pontin52 and Reptin52 function as antagonistic regulators of beta-catenin signalling activity
2000
β-catenin is a target for the ubiquitin–proteasome pathway
1997 Standout
Brachyury is a target gene of the Wnt/β-catenin signaling pathway
2000
Casein Kinase II Phosphorylation of E-cadherin Increases E-cadherin/β-Catenin Interaction and Strengthens Cell-Cell Adhesion
2000
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
2011
Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein
1998