Standout Papers
Citation Impact
Citing Papers
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
2001 StandoutScience
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
2007 StandoutScience
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
2002 Standout
Regulation of Angiogenesis by Oxygen and Metabolism
2009
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.
2002
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307
2000
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Insulin-stimulated GLUT4 Translocation in Adipocytes Is Dependent upon Cortical Actin Remodeling
2001
Inflammation and metabolic disorders
2006 StandoutNature
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
1999
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
2006 Standout
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999
Oncogenic kinase signalling
2001 StandoutNature
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
2001
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 Standout
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B
1999
The biology and management of non-small cell lung cancer
2018 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia
2006
Cellular survival: a play in three Akts
1999 Standout
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
1999
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
2001
Rho GTPases in cell biology
2002 StandoutNature
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence
1999
FOXOs: signalling integrators for homeostasis maintenance
2013
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Perturbations of the AKT signaling pathway in human cancer
2005
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The emerging roles of forkhead box (Fox) proteins in cancer
2007
Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles
2010
FoxO1 is involved in the antineoplastic effect of calorie restriction
2010
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
2001
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway
1999
Origin and physiological roles of inflammation
2008 StandoutNature
The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
2003
Mechanism of activation and function of protein kinase B
1998
Signaling pathways in insulin action: molecular targets of insulin resistance
2000
The Hallmarks of Aging
2013 Standout
The CD28 Signaling Pathway Regulates Glucose Metabolism
2002
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit
1999
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
1998 Standout
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer.
2001
Loss of PTEN facilitates HIF-1-mediated gene expression
2000
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
2002
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B
2002
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
2002
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
2003
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
2000
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
1999
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
The PI3K‒PDK1 connection: more than just a road to PKB
2000
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Fast structural responses of gap junction membrane domains to AB5 toxins
2013 StandoutNobel
PKB/Akt
2001
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
2008
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
PI 3-kinase, mTOR, protein synthesis and cancer
2001
Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide
1998
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
1998
KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p
1998
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Toll-like receptor (TLR) polymorphisms in African children: CommonTLR-4variants predispose to severe malaria
2005
Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors
2002
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice
2002
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway
2005
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
2000
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
The PI3K–PDK1 connection: more than just a road to PKB
2000
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
2000 StandoutNobel
Dynamic FoxO transcription factors
2007
Works of Andreas Barthel being referenced
Sorting and budding of constitutive secretory vesicles in hepatocytes and hepatoma cells
1995
Akt Modulates STAT3-mediated Gene Expression through a FKHR (FOXO1a)-dependent Mechanism
2003
Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress
2005
Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1
1999
Differential Regulation of Endogenous Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression by the Forkhead Transcription Factor FKHR in H4IIE-Hepatoma Cells
2001
FoxO proteins in insulin action and metabolism
2005
Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene
1998
Protein Kinase C Modulates the Insulin-Stimulated Increase in Akt1 and Akt3 Activity in 3T3-L1 Adipocytes
1998
Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines
1999 Standout
Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt
1998
Impaired adrenal stress response in Toll-like receptor 2-deficient mice
2004
A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the obGene Product, Leptin, in 3T3-L1 Adipocytes
1997
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
2001
Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase
2002