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Glucose Transporter in Insulin Sensitive Tissues of Lean and Obese Mice. Effect of the Thermogenic Agent BRL 26830A*
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Disruption of BCATm in Mice Leads to Increased Energy Expenditure Associated with the Activation of a Futile Protein Turnover Cycle
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Metabolic syndrome, diabetes, and hyperuricemia
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AMPK at the Nexus of Energetics and Aging
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Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.
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Flotillins and the PHB Domain Protein Family: Rafts, Worms and Anaesthetics
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Synip
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MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid β, Novel Targets in Sporadic Alzheimer's Disease
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Sympathetic activity is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet
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Insulin and insulin resistance:
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Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner
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1995
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
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2005
DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat.
1994
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2014
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The Hallmarks of Aging
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Energy Metabolism in the Liver
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2000
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Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects
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2011
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AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
2015
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Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans
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Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats
1999
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Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle
2004
Insulin signaling to hepatic lipid metabolism in health and disease
2011
Comparison of Hormone-Sensitive Lipase Activity in Visceral and Subcutaneous Human Adipose Tissue1
1997
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
2014
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.
1994
Using mouse models to dissect the genetics of obesity
2002
Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes
2005 StandoutNobel
AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
2011
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
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Visceral Adiposity Index
2010
Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice
2018
Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle.
1996
Crucial role of the small GTPase Rac1 in insulin‐stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma
2010
Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity
2015
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
2002
Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats
1998
Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4
1993
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Cloning of BUG demonstrates the existence of a brown preadipocyte distinct from a white one
2001
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
2003 StandoutNobel
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
2007
Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin
1996
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Waist Girth Does Not Predict Metabolic Complications in Severely Obese Men
2006
Cig30, a Mouse Member of a Novel Membrane Protein Gene Family, Is Involved in the Recruitment of Brown Adipose Tissue
1997
Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults
2012
Activation of Protein Kinase Cζ Induces Serine Phosphorylation of VAMP2 in the GLUT4 Compartment and Increases Glucose Transport in Skeletal Muscle
2001
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
2000
Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells
2008
Oxidative Stress and Diabetic Complications
2010 Standout
Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters
1998
Brown Adipose Tissue: Function and Physiological Significance
2004 Standout
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts
1999
Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women
2011
Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity
2016 Standout
Analysis of GLUT4 Distribution in Whole Skeletal Muscle Fibers: Identification of Distinct Storage Compartments That Are Recruited by Insulin and Muscle Contractions
1998
Fiber Types in Mammalian Skeletal Muscles
2011 Standout
Differential global gene expression in red and white skeletal muscle
2001
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 Nobel
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
2003
Role of β1- and β3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes
1997
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Induction of GLUT-1 protein in adult human skeletal muscle fibers
2000
Regional Differences in Adipose Tissue Metabolism in Women
2006
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
Sex Differences in Visceral Fat Lipolysis and Metabolic Complications of Obesity
1997
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
2017
The glucose transporter family: structure, function and tissue-specific expression
1993
Syntaxin 4, VAMP2, and/or VAMP3/Cellubrevin Are Functional Target Membrane and Vesicle SNAP Receptors for Insulin-Stimulated GLUT4 Translocation in Adipocytes
1997
Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
2010
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
2007
Glucose transporters in single skeletal muscle fibers. Relationship to hexokinase and regulation by contractile activity.
1994
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
2013
Skeletal muscle fibre plasticity in response to selected environmental and physiological stimuli.
2009
Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure
1993
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice
1993
Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1
2013
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
2012
Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men
1997
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
2012
Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity
2007
Complete sequence of the bithorax complex of Drosophila.
1995 StandoutNobel
The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
2014
Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes
2002
Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
2016
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin
1996
Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
2014
Mitochondrial dysfunction and insulin resistance: an update
2014
Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle
2013
Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells
1998
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Glucocorticoids Down-Regulate Glucose Uptake Capacity and Insulin-Signaling Proteins in Omental But Not Subcutaneous Human Adipocytes
2004
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
2016
Works of André Marette being referenced
Expression of β subunit isoforms of the Na+,K+‐ATPase is muscle type‐specific
1993
Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
2009
Molecular mechanisms of inflammation in obesity-linked insulin resistance
2003
Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification
2020
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
2013
Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway
2005
Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women
1997
Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes
2004
Glucose transporter 4 and insulin receptor substrate–1 messenger RNA expression in omental and subcutaneous adipose tissue in women
2009
Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity
2020
Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO− Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle
2010
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
2010
Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings
2002
Effect ofLactobacillus rhamnosusCGMCC1.3724 supplementation on weight loss and maintenance in obese men and women
2013
Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance
2004
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
2001
Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway
2001
Hepatocyte-Specific Ptpn6 Deletion Promotes Hepatic Lipid Accretion, but Reduces NAFLD in Diet-Induced Obesity: Potential Role of Pparγ
2013
Exercise Induces the Translocation of GLUT4 to Transverse Tubules from an Intracellular Pool in Rat Skeletal Muscle
1996
Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase
2004
What signals are involved in the stimulation of glucose transport by insulin in muscle cells?
1993
Visceral obesity and the heart
2008
The α-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro
2008
Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment
2009
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis
2006
Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
2012
Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion
2012
Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance
2012
Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle
2003
Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat–Fed Mice
2010
Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase
1997
Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice
2010
Major thermogenic defect associated with insulin resistance in brown adipose tissue of obese diabetic SHR/N-cp rats
1991
Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles
2000
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle
1992
Mechanism linking insulin resistance to defective thermogenesis in brown adipose tissue of obese diabetic SHR/N-cp rats.
1991
The transferrin receptor defines two distinct contraction-responsive GLUT4 vesicle populations in skeletal muscle.
2000
Noradrenaline stimulates glucose transport in rat brown adipocytes by activating thermogenesis. Evidence that fatty acid activation of mitochondrial respiration enhances glucose transport
1991
Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability
2005
Effect of Diabetes on Glucoregulation: From glucose transporters to glucose metabolism in vivo
1992
Cytokines and endotoxin induce cytokine receptors in skeletal muscle
2000
Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures
1994
Insulin-induced translocation of Na(+)-K(+)-ATPase subunits to the plasma membrane is muscle fiber type specific
1996
Regional variation in adipose tissue metabolism of severely obese premenopausal women.
1995
Mechanism of norepinephrine stimulation of glucose transport in isolated rat brown adipocytes.
1990
Defective Insulin-Induced GLUT4 Translocation in Skeletal Muscle of High Fat–Fed Rats Is Associated With Alterations in Both Akt/Protein Kinase B and Atypical Protein Kinase C (ζ/λ) Activities
2001
Specific decrease of mitochondrial thermogenic capacity in brown adipose tissue of obese SHR/N-cp rats
1993
Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.
1992
Role of Dietary Proteins and Amino Acids in the Pathogenesis of Insulin Resistance
2007
Expression of Nitric Oxide Synthase in Skeletal Muscle: A Novel Role for Nitric Oxide as a Modulator of Insulin Action
1997
Biochemical and immunocytochemical localization of the ‘GLUT5 glucose transporter’ in human skeletal muscle
1992
Insulin Induces the Translocation of GLUT4 From a Unique Intracellular Organelle to Transverse Tubules in Rat Skeletal Muscle
1992
Stimulation of glucose transport by insulin and norepinephrine in isolated rat brown adipocytes
1989
Defective metabolic effects of norepinephrine and insulin in obese Zucker rat brown adipose tissue
1990
Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action
1997
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
2000
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
2007
A new procedure for the isolation of plasma membranes, T tubules, and internal membranes from skeletal muscle
1996
Mechanism of adipose tissue iNOS induction in endotoxemia
1999
Norepinephrine- and insulin-resistant glucose transport in brown adipocytes from diabetic SHR/N-cp rats
1993
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
2010
Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent
1998
AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
2014
The AMP‐activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen‐activated protein kinases α and β in skeletal muscle
2003
Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigmaThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.
2006