Citation Impact
Citing Papers
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
DNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis
2008
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
2013
DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT
2013
The DNA-damage response in human biology and disease
2009 StandoutNature
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
DNA damage checkpoints in stem cells, ageing and cancer
2012
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
Inflammatory networks underlying colorectal cancer
2016
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
2012
The genetics of ageing
2010 StandoutNature
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
2010
Immunoaging induced by hematopoietic stem cell aging
2011
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
2007 Nature
Cellular Senescence in Cancer and Aging
2007 Standout
Origins of Metastatic Traits
2013
Cellular senescence and organismal aging
2008
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
Telomeres and telomerase in cancer
2009
Hydrolytic function of Exo1 in mammalian mismatch repair
2014 StandoutNobel
Axis of ageing: telomeres, p53 and mitochondria
2012
Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes
2009
New plays in the p53 theater
2010
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
Telomere length, stem cells and aging
2007
The telomere syndromes
2012 Nobel
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
DNA damage in aging, the stem cell perspective
2019
How stem cells age and why this makes us grow old
2007
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
p21 in cancer: intricate networks and multiple activities
2009 Standout
Emerging cytokine networks in colorectal cancer
2015
FoxO1 is involved in the antineoplastic effect of calorie restriction
2010
Metabolic Regulation by p53 Family Members
2013
CRISPR-mediated direct mutation of cancer genes in the mouse liver
2014 Nature
Stems Cells and the Pathways to Aging and Cancer
2008
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
2012
Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response
2012
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
2009
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
2010 Nature
Distinct Activities of Exonuclease 1 and Flap Endonuclease 1 at Telomeric G4 DNA
2010
EMT: 2016
2016 Standout
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
2013
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
2010 StandoutNobel
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Role of shelterin in cancer and aging
2010
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study
2009 StandoutNobel
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
2008
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
The role of senescent cells in ageing
2014 StandoutNature
Inflammation and cancer: tissue regeneration gone awry
2016
Notch is a direct negative regulator of the DNA-damage response
2015
The Hallmarks of Aging
2013 Standout
Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair
2009 StandoutNobel
To be, or not to be
2013
Inflammation and cancer stem cells
2013
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Metastatic colonization by circulating tumour cells
2016 StandoutNature
DNA damage response and cellular senescence in tissues of aging mice
2009
The role of telomeres and telomerase in stem cell aging
2010
Mechanisms and functions of DNA mismatch repair
2007
DNA mismatch repair: Molecular mechanism, cancer, and ageing
2008
Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment
2016
Unmasking senescence: context-dependent effects of SASP in cancer
2019
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
2013
Involvement of the β Clamp in Methyl-directed Mismatch Repair in Vitro
2009 StandoutNobel
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
2008
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
MammalianExo1encodes both structural and catalytic functions that play distinct roles in essential biological processes
2013
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Genomic Engineering and the Future of Medicine
2015 StandoutNobel
Syndromes of Telomere Shortening
2009
Adult-onset, short-term dietary restriction reduces cell senescence in mice
2010
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Spermidine in health and disease
2018 StandoutScience
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Double-Strand Break End Resection and Repair Pathway Choice
2011
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
2015
Metabolic reprogramming and cancer progression
2020 StandoutScience
Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation
2011
Visualizing the dynamics of p21 Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
2007
How Shelterin Protects Mammalian Telomeres
2008 Standout
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci
2016
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Works of André Lechel being referenced
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
2015
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
2006
Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice
2007
Telomerase Deletion Limits Progression of p53-Mutant Hepatocellular Carcinoma With Short Telomeres in Chronic Liver Disease
2007
Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis†
2007
Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors
2012
Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers
2013
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
2016 Nature
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
2009
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
2012
Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation
2012
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
2005
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction
2011