Standout Papers
Citation Impact
Citing Papers
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
2004
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
2001 Science
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
1993 StandoutScience
Alzheimer's disease β-amyloid peptides are released in association with exosomes
2006
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
2011
Biochemical and anatomical redistribution of tau protein in Alzheimer's disease.
1993
Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011
A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐β peptide
2014
Heparin-Protein Interactions
2002 Standout
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
1999
Role of cholesterol and lipid organization in disease
2005 Nature
Epitopes that span the tau molecule are shared with paired helical filaments
1988
The pathological process underlying Alzheimer’s disease in individuals under thirty
2010
Neurofibrillary tangle parkinsonian disorders?tau pathology andtau genetics
1999
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
2009
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
2007 Standout
Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
2006
Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation
2006
Statins and the risk of dementia
2000
Evaluating triggers and enhancers of tau fibrillization
2005
Screening for Inhibitors of Tau Polymerization
2005
Tau protein pathology in neurodegenerative diseases
1998
Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
2002
Intricate relationships between naked viruses and extracellular vesicles in the crosstalk between pathogen and host
2018
Alzheimer's disease
2011 Standout
Problems and Solutions in the Genetic Analysis of Late-Onset Alzheimer’s Disease
2004
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Exosomes in the Diseased Brain: First Insights from In vivo Studies
2017
Tau phosphorylation and aggregation in Alzheimer's disease pathology
2006
Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of β-amyloid protein precursor
1992
Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies
1998
Genetic evidence for the involvement of τ in progressive supranuclear palsy
1997
Neuroimaging in Alzheimer disease: an evidence-based review
2003
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
2008
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
2010
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
2000
Exosomes as new diagnostic tools in CNS diseases
2015
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
2008
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005
Scaffolding microdomains and beyond: the function of reggie/flotillin proteins
2005
CSF Biomarkers
2009
Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
2011
Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells
2004
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment
2003
O-GlcNAc cycling: Implications for neurodegenerative disorders
2009
Prion-like transmission of protein aggregates in neurodegenerative diseases
2010
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
1997
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
2003
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein
2006
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
2007
Transgenic models of Alzheimer’s disease: Learning from animals
2005
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
2008
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
2004
Abnormal microtubule packing in processes of SF9 cells expressing the FTDP‐17 V337M tau mutation
1999
p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid βIn Vivo
2006
Aβ peptides can enter the brain through a defective blood–brain barrier and bind selectively to neurons
2007
Declarative memory impairments in Alzheimer's disease and semantic dementia
2005
Clinical and Pathological Diagnosis of Frontotemporal Dementia
2001
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
2000
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
2009 Standout
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
1989 Standout
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
2006
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
2010
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
2001
Purification of Recombinant Tau Protein and Preparation of Alzheimer-Paired Helical Filaments In Vitro
2005
α-Synuclein: Normal Function and Role in Neurodegenerative Diseases
2004
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
Effect of a dipeptide inhibiting ubiquitin-mediated protein degradation on nerve-dependent limb regeneration in the newt
1996
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress
2004
Non-coding RNAs in human disease
2011 Standout
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid β, Novel Targets in Sporadic Alzheimer's Disease
2011
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
tau protein in cerebrospinal fluid
1995
Post-translational modifications of tau protein in Alzheimer’s disease
2004
The Low Density Lipoprotein Receptor-related Protein 1B Retains β-Amyloid Precursor Protein at the Cell Surface and Reduces Amyloid-β Peptide Production
2004
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
2006
Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure
2001
Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting
2006
Tau oligomers and aggregation in Alzheimer’s disease
2009
Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord
2000
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1‐42
2010
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
2000
Retromer disruption promotes amyloidogenic APP processing
2011
A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)
1999
The role of GSK3 in Alzheimer disease
2009
Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice
2005
ADAMs family members as amyloid precursor protein α‐secretases
2003
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Transgenic animal models of tauopathies
2004
Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
2008
A Decade of Tau Transgenic Animal Models and Beyond
2007
Systematic Study of Drosophila MicroRNA Functions Using a Collection of Targeted Knockout Mutations
2014
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
2008
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
2010
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study
2009
Tau Filament Formation in Transgenic Mice Expressing P301L Tau
2001
Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome
2010
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
2000
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice
2006
Where do you know what you know? The representation of semantic knowledge in the human brain
2007 Standout
A Dominant Role for FE65 (APBB1) in Nuclear Signaling
2005
Intraneuronal β-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response
2005
Genetically Augmenting Aβ42 Levels in Skeletal Muscle Exacerbates Inclusion Body Myositis-Like Pathology and Motor Deficits in Transgenic Mice
2006
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
2009
Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: Implications for the pathogenesis of Alzheimer's disease
2005
The molecular pathology of Alzheimer's disease
1991 Standout
The use of mass spectrometry for the proteomic analysis of glycosylation
2006
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
2007
The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice
2005
Functional MAPT haplotypes: Bridging the gap between genotype and neuropathology
2007
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Significant association between the tau gene A0/A0 genotype and Parkinson's disease
2000
The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code"
2005
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
1992
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
1986
Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
2003
Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease.
1991
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein
2002
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
1988 StandoutNobel
Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.
1994
Neurodegenerative Tauopathies
2001 Standout
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
1987
Ligand-Dependent Inhibition and Reversal of Tau Filament Formation
2004
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment
2002
Amyloid-β, Tau, and Dementia
2009
A Century of Alzheimer's Disease
2006 StandoutScience
Tau phosphorylation and proteolysis: Insights and perspectives
2006
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degenerationin vivo
2005
Mutations causing neurodegenerative tauopathies
2004
Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents
1999 Nobel
Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
2014
Repression of α-synuclein expression and toxicity by microRNA-7
2009
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.
1989
Pathways of tau fibrillization
2004
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression
2016 StandoutNobel
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
2000
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
1999
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
1994 StandoutScience
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease
2005 Science
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
1998 Nobel
A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids
1986 StandoutNobel
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo
1984
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
Molecular probes for the development and plasticity of neural crest derivatives
1985 StandoutNobel
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes
2018
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
The role of extracellular vesicles in neurodegenerative diseases
2016
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Monoclonal antibodies to mammalian neurofilaments
1981
Proline‐Directed Protein Kinase (p34cdc2/p58cyclin A) Phosphorylates Bovine Neurofilaments
1992
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
2006
Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.
1991
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease
2010
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
NMR structure of the bovine prion protein
2000 StandoutNobel
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve
2009
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments
2006
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
2005
Early segregation of a neuronal precursor cell line in the neural crest as revealed by culture in a chemically defined medium
1983
Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method
1987
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
1993
Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein.
1998
Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics
2010 StandoutNobel
Amyloid ? protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein
1998
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Semantic representations in the temporal pole predict false memories
2016 StandoutNobel
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of André Delacourte being referenced
The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons
2009 Science
Synthesis and Regulation of Apolipoprotein E during the Differentiation of Human Neuronal Precursor NT2/D1 Cells into Postmitotic Neurons
2000
Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE
1999
Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease
1994
Transformation of degenerating neurofibrils into amyloid substance in Alzheimer's disease: Histochemical and immunohistochemical studies
1987
Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down's syndrome
1991
Abnormal tau species are produced during Alzheimer's disease neurodegenerating process
1989
Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy‐like tauopathy
2002
Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases
1997
Absence of β-Amyloid Deposits After Immunization in Alzheimer Disease With Lewy Body Dementia
2007
An Antiserum to the N-Terminal Subsequence of the Alzheimer Amyloid Beta Protein Does Not React With Neurofibrillary Tangles
1989
Association of atp synthase α-chain with neurofibrillary degeneration in alzheimer’s disease
2003
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease
1992
Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease
1999
Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages
1989
Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration
1999
Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins—a role in nuclear localization
2003
Specific tau variants in the brains of patients with myotonic dystrophy
1996
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
2007 Standout
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies
2004
Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type
1990
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
2008
Transforming Growth Factor-β1 Potentiates Amyloid-β Generation in Astrocytes and in Transgenic Mice
2003
Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their τ isoform distribution and phosphorylation
1998
Functional Characterization of FTDP-17 tau Gene Mutations through Their Effects on Xenopus Oocyte Maturation
2002
Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases
2004
Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease
2004
Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome
1990
Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease
1990
Mapping of neurofibrillary degeneration in Alzheimer's disease: evaluation of heterogeneity using the quantification of abnormal tau proteins
1992
Alkalizing Drugs Induce Accumulation of Amyloid Precursor Protein By-products in Luminal Vesicles of Multivesicular Bodies
2007
Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease
1992
Pathological Determinants of the Transition to Clinical Dementia in Alzheimer's Disease
2002
Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β‐amyloid load
2005
Presence of abnormally phosphorylated Tau proteins in the entorhinal cortex of aged non-demented subjects
1992
Neurofibrillary Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration
1999
Specific Pathological Tau Protein Variants Characterize Pickʼs Disease
1996
ApoE Synthesis in Human Neuroblastoma Cells
1997
Brain Microvascular Changes in Alzheimer's Disease and Other Dementiasa
1997
New immunoassay for the mapping of neurofibrillary degeneration in Alzheimer's disease using two monoclonal antibodies against human paired helical filament tau proteins
1995
Distortion of Allelic Expression of Apolipoprotein E in Alzheimer's Disease
1997
Electrophysiological effects of 25–35 amyloid-β-protein on guinea-pig lateral septal neurons
1993
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Tau aggregation in the hippocampal formation: an ageing or a pathological process?
2002
Abnormal Tau proteins in progressive supranuclear palsy
1991
Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes
1998
Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide
1993
Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
1993
Proteasome inhibition and Tau proteolysis: an unexpected regulation
2004
Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects
1995
Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments
1989
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
2004
Pathological τ proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders
1997
Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease
1997
Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital
1994
Tau protein as a differential biomarker of tauopathies
2004
O-GlcNAc Glycosylation and Neurological Disorders
2003
De la physiopathologie au traitement de la maladie d’Alzheimer
2006
Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains
2003
Neuronal membrane cholesterol loss enhances amyloid peptide generation
2004
Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease
1996
Two‐Dimensional Characterization of Paired Helical Filament‐Tau from Alzheimer's Disease: Demonstration of an Additional 74‐kDa Component and Age‐Related Biochemical Modifications
1997
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease
1999
AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease
1996
Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region
1994
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.
1995
General and dramatic glial reaction in Alzheimer brains
1990
Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
2007
Intermediate filament proteins in mouse brain cells cultured in the presence or absence of fetal calf serum
1982
[Demonstration of a specific profile of pathological Tau proteins in frontotemporal dementia cases].
1995
Study of the 10-nm-filament fraction isolated during the standard microtubule preparation
1980
Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy
2002
The polypeptides of isolated brain 10nm filaments and their association with polymerized tubulin
1979
Brain plasmin enhances APP α‐cleavage and Aβ degradation and is reduced in Alzheimer's disease brains
2000
[Tau story: from frontotemporal dementia to other tauopathies].
2002
Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments
1986
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease
2002
Anti-PHF antibodies: An immunohistochemical marker of the lesions of the Alzheimer's disease
1985
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
2008
Sequence of neurofibrillary changes in aging and Alzheimer's disease: A confocal study with phospho-tau antibody, AD2
2001