Standout Papers
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Property‐Driven Development of Passively Permeable Macrocyclic Scaffolds Using Heterocycles**
2022
Stereochemistry of Glutamate Receptor Agonist Efficacy: Engineering a Dual-Specificity AMPA/Kainate Receptor
2004
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid, a Potent and Selective Agonist at the GluR5 Subtype of Ionotropic Glutamate Receptors. Synthesis, Modeling, and Molecular Pharmacology
2003
Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding
2006
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Kainate receptors: Pharmacology, function and therapeutic potential
2008
Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
2005
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
2009
Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
2008
Concanavalin‐A reports agonist‐induced conformational changes in the intact GluR6 kainate receptor
2006
Crystal structure of the kainate receptor GluR5 ligand‐binding core in complex with (S)‐glutamate
2005
Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
2006
Synthesis and Pharmacology of Willardiine Derivatives Acting as Antagonists of Kainate Receptors
2005
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2α,3β,4β)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study
2003
Glutamate receptor ion channels
2005 Standout
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines
2010 StandoutNobel
Glutamate receptors at atomic resolution
2006 Nature
Environmental and health effects of the herbicide glyphosate
2017 Standout
Conformational Changes in the Ligand-binding Domain of a Functional Ionotropic Glutamate Receptor
2005
Solution X-ray Scattering Evidence for Agonist- and Antagonist-induced Modulation of Cleft Closure in a Glutamate Receptor Ligand-binding Domain
2005
Structural aspects of AMPA receptor activation, desensitization and deactivation
2007
3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists
2006
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Descending control of pain
2002 Standout
Glutamate uptake
2001 Standout
Regulation of AMPA Receptor Gating by Ligand Binding Core Dimers
2004
AMPA Receptor Trafficking at Excitatory Synapses
2003
DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
2010 Standout
Tweaking Agonist Efficacy at N-Methyl-d-aspartate Receptors by Site-Directed Mutagenesis
2005
Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor
2011
Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors — Focus on subtypes iGlu5–7
2009
Quantifying Ligand Bias at Seven-Transmembrane Receptors
2011 StandoutNobel
Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
2005
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
2013 StandoutNobel
Molecular Dynamics Simulation for All
2018 Standout
Role of computer-aided drug design in modern drug discovery
2015
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
Conformational restriction blocks glutamate receptor desensitization
2006
Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity
2018 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
2011 Standout
Competitive AMPA receptor antagonists
2006
Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get”
2009
Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors
2005
Homeostatic plasticity in the developing nervous system
2004 Standout
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
2012 StandoutNobel
How were new medicines discovered?
2011 Standout
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
2005
Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation
2013 StandoutNobel
Update of TTD: Therapeutic Target Database
2009
Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
2010
LTP and LTD
2004 Standout
Structural and Single-Channel Results Indicate That the Rates of Ligand Binding Domain Closing and Opening Directly Impact AMPA Receptor Gating
2008
1,2,3-Triazolyl amino acids as AMPA receptor ligands
2010
Performance of machine-learning scoring functions in structure-based virtual screening
2017
Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5
2007
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist
2004
HIT: linking herbal active ingredients to targets
2010
Molecular Dynamics Simulations of the Ligand-binding Domain of an N-Methyl-d-aspartate Receptor
2006
Structural basis for partial agonist action at ionotropic glutamate receptors
2003
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-NS1209
2006
Glutamate Receptor Gating
2004
The Relationship between Agonist Potency and AMPA Receptor Kinetics
2006
Two Solutions for the Same Problem: Multiple Binding Modes of Pyrrolidine-Based HIV-1 Protease Inhibitors
2011
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
2004 StandoutNobel
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
2013 Standout
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
2012
3d Transition Metals for C–H Activation
2018 Standout
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
2005
Halogen bond directionality translates tecton geometry into self-assembled architecture geometry
2013
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists
2007
Analysis of Neighborhood Behavior in Lead Optimization and Array Design
2008
Outstanding challenges in protein–ligand docking and structure‐based virtual screening
2011
Ionotropic glutamate-like receptor δ2 binds d -serine and glycine
2007
MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
2012 Standout
Extended-Connectivity Fingerprints
2010 Standout
Covalent O–H Bonds as Electron Traps in Proton-Rich Rutile TiO2 Nanoparticles
2014 StandoutNobel
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Jaguar: A high‐performance quantum chemistry software program with strengths in life and materials sciences
2013
Computational design of environmental sensors for the potent opioid fentanyl
2017 StandoutNobel
Probing the Function, Conformational Plasticity, and Dimer−Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal,
2003
Functional Characterization of Tet-AMPA [Tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic Acid] Analogues at Ionotropic Glutamate Receptors GluR1−GluR4. The Molecular Basis for the Functional Selectivity Profile of 2-Bn-Tet-AMPA
2007
Copper-catalyzed direct cross-coupling of 1,3,4-oxadiazoles with N-tosylhydrazones: efficient synthesis of benzylated 1,3,4-oxadiazoles
2013
Functional Insights from Glutamate Receptor Ion Channel Structures
2012
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype
2013 StandoutNobel
QM/MM As a Tool in Fragment Based Drug Discovery. A Cross-Docking, Rescoring Study of Kinase Inhibitors
2009
Thermodynamic and Structural Effects of Conformational Constraints in Protein−Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization
2009
ETCM: an encyclopaedia of traditional Chinese medicine
2018 Standout
Oxadiazole isomers: all bioisosteres are not created equal
2012
Molecular Visualization on the Holodeck
2018
Emerging structural explanations of ionotropic glutamate receptor function
2004
Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design
2016
The Halogen Bond
2016 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
2020 Standout
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
2012
OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
2015 Standout
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
2016
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
2003
Microsecond-to-Millisecond Conformational Dynamics Demarcate the GluR2 Glutamate Receptor Bound to Agonists Glutamate, Quisqualate, and AMPA
2005
Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)
2003
Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
2007 StandoutNobel
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid
2005
A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist
2007
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Improving the Efficiency of Ligand-Binding Protein Design with Molecular Dynamics Simulations
2019 StandoutNobel
Role of dimer interface in activation and desensitization in AMPA receptors
2010
Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain
2009
Substrate-Specific Screening for Mutational Hotspots Using Biased Molecular Dynamics Simulations
2017
Works of Anders Hogner being referenced
Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
2002
3D-Lab: A Collaborative Web-Based Platform for Molecular Modeling
2016
Oxadiazoles in Medicinal Chemistry
2011 Standout
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties
2016
Do Structurally Similar Ligands Bind in a Similar Fashion?
2006
Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity
2003
Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design
2016
Competitive Antagonism of AMPA Receptors by Ligands of Different Classes: Crystal Structure of ATPO Bound to the GluR2 Ligand-Binding Core, in Comparison with DNQX
2002
Membrane Permeability in Cyclic Peptides is Modulated by Core Conformations
2020