Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening
2007
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Regulation of microRNA function in animals
2018 Standout
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
2012 StandoutNature
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans
2004 StandoutNobel
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
Structure-Activity Relationships of G Protein-Coupled Receptors
1999
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Arrestin-mediated ERK Activation by Gonadotropin-releasing Hormone Receptors
2005
β‐arrestin1 phosphorylation by GRK5 regulates G protein‐independent 5‐HT4 receptor signalling
2009
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
2006 StandoutNobel
RNA Binding-independent Dimerization of Adenosine Deaminases Acting on RNA and Dominant Negative Effects of Nonfunctional Subunits on Dimer Functions
2007
The role of autophagy in neurodegenerative disease
2013 Standout
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
2011 Standout
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors
2008
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
2007 Standout
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation
2002
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
2007
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
2015
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
The insulin receptor: a prototype for dimeric, allosteric membrane receptors?
2008
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
A-to-I editing of coding and non-coding RNAs by ADARs
2015
Regulated portals of entry into the cell
2003 StandoutNature
Molecular Dynamics Simulation for All
2018 Standout
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
β-Arrestin Binding to the β2-Adrenergic Receptor Requires Both Receptor Phosphorylation and Receptor Activation
2005 Nobel
Agonist-promoted Internalization of a Ternary Complex between Calcitonin Receptor-like Receptor, Receptor Activity-modifying Protein 1 (RAMP1), and β-Arrestin
2001
Adhesion molecule signalling: not always a sticky business
2011
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
2004 StandoutNobel
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Interactions between Brain-derived Neurotrophic Factor and the TRKB Receptor
1997
Pharmacological Chaperones for Misfolded Gonadotropin-Releasing Hormone Receptors
2011
Stimulation by ghrelin of p42/p44 mitogen‐activated protein kinase through the GHS‐R1a receptor: Role of G‐proteins and β‐arrestins
2007
Membrane-Proximal Region of the Carboxyl Terminus of the Gonadotropin-Releasing Hormone Receptor (GnRHR) Confers Differential Signal Transduction between Mammalian and Nonmammalian GnRHRs
2004
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Cell‐based assays in GPCR drug discovery
2008
The Discovery and Development of Liraglutide and Semaglutide
2019
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes
2007 StandoutNobel
Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance
2008
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Homo- and Hetero-oligomerization of Thyrotropin-releasing Hormone (TRH) Receptor Subtypes
2002 StandoutNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
2007
Seven-transmembrane receptors
2002 StandoutNobel
Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques
2011
Ligand regulation of green fluorescent protein‐tagged forms of the human β1‐ and β2‐adrenoceptors; comparisons with the unmodified receptors
2000
Posttranscriptional recoding by RNA editing
2012
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor
2002 StandoutNobel
β-arrestin-mediated receptor trafficking and signal transduction
2011 StandoutNobel
Arresting developments in heptahelical receptor signaling and regulation
2002 StandoutNobel
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Dynamin and Its Role in Membrane Fission
2000
Functions and Regulation of RNA Editing by ADAR Deaminases
2010
Uptake of Circulating Insulin-Like Growth Factors (IGFs) into Cerebrospinal Fluid Appears to Be Independent of the IGF Receptors as Well as IGF-Binding Proteins**This work was supported by Centers for Disease Control and Prevention Grant R49/CCR811509.
2001
Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
1997
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
Increased Acute Inflammation, Leukotriene B4-Induced Chemotaxis, and Signaling in Mice Deficient for G Protein-Coupled Receptor Kinase 6
2003 StandoutNobel
Once-Weekly Semaglutide in Adults with Overweight or Obesity
2021 Standout
A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands
2017
Nanostructured Plasmonic Sensors
2008 Standout
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
2010 Standout
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Dissecting the roles of TRBP and PACT in double‐stranded RNA recognition and processing of noncoding RNAs
2015
Trafficking of G Protein–Coupled Receptors
2006 StandoutNobel
Pharmacological Demarcation of the Growth Hormone, Gut Motility and Feeding Effects of Ghrelin Using a Novel Ghrelin Receptor Agonist
2008
Works of Anders Heding being referenced
Direct demonstration of NCAMcis-dimerization and inhibitory effect of palmitoylation using the BRET2technique
2010
Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization
1999
Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain
2006
Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer
2007
Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth Factor-binding Protein-3
1996
Development of a BRET2 Screening Assay Using β-Arrestin 2 Mutants
2004
GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation
2016
Gonadotropin-releasing Hormone Receptors with Intracellular Carboxyl-terminal Tails Undergo Acute Desensitization of Total Inositol Phosphate Production and Exhibit Accelerated Internalization Kinetics
1998
β-Arrestin-Based Bret2 Screening Assay for the “Non”-β-Arrestin Binding CB1 Receptor
2009
Bioluminescence Resonance Energy Transfer as a Screening Assay: Focus on Partial and Inverse Agonism
2006
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
Use of the BRET 7TM receptor/β-arrestin assay in drug discovery and screening
2004
The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a -Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers -Arrestin Dependency
2000
Nonpeptide and Peptide Growth Hormone Secretagogues Act Both as Ghrelin Receptor Agonist and as Positive or Negative Allosteric Modulators of Ghrelin Signaling
2005
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a β-Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers β-Arrestin Dependency
2000
Cooperative Binding of Insulin-Like Peptide 3 to a Dimeric Relaxin Family Peptide Receptor 2
2007