Standout Papers

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta agai... 2020 2026 2022 20241.2k
  1. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020)
    Timothy P. Sheahan, Amy Sims et al. Nature Communications

Citation Impact

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2010
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
2010
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2017
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Intracellular Localization and Protein Interactions of the Gene 1 Protein p28 during Mouse Hepatitis Virus Replication
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Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation
2008
Broad-spectrum coronavirus antiviral drug discovery
2019
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
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Nidovirus transcription: how to make sense…?
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Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
2017
A molecular pore spans the double membrane of the coronavirus replication organelle
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Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase
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RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase
2019
Drug treatment options for the 2019-new coronavirus (2019-nCoV)
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A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge
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MERS-CoV spike protein: a key target for antivirals
2016
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
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Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism
2016
A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant
2014
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
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Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
2018
A Novel Coronavirus from Patients with Pneumonia in China, 2019
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Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4
2014
Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China
2014
Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection
2014
Human coronaviruses OC43 and HKU1 bind to 9- O -acetylated sialic acids via a conserved receptor-binding site in spike protein domain A
2019
Cyclosporin A inhibits the replication of diverse coronaviruses
2011
Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication
2017
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
2020
Continuous and Discontinuous RNA Synthesis in Coronaviruses
2015
Novel β-Barrel Fold in the Nuclear Magnetic Resonance Structure of the Replicase Nonstructural Protein 1 from the Severe Acute Respiratory Syndrome Coronavirus
2007 Nobel
Duty to Plan: Health Care, Crisis Standards of Care, and Novel Coronavirus SARS-CoV-2
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Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection
2014
Airborne transmission of respiratory viruses
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Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
2013
Strategy for Systematic Assembly of Large RNA and DNA Genomes: Transmissible Gastroenteritis Virus Model
2000
Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2′-O-Methyltransferase Activity
2014
Coronavirus Infections—More Than Just the Common Cold
2020 Standout
Emerging coronaviruses: Genome structure, replication, and pathogenesis
2020 Standout
In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins
2017
Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics
2020
Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate
2021
Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein
2009
Fair Allocation of Scarce Medical Resources in the Time of Covid-19
2020 Standout
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation
2006
RNA Replication of Mouse Hepatitis Virus Takes Place at Double-Membrane Vesicles
2002
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience

Works of Amy Sims being referenced

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis
2017
Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures
2010
The NSP2 Proteins of Mouse Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication
2006
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
2019
Development of Mouse Hepatitis Virus and SARS-CoV Infectious cDNA Constructs
2005
Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants
2006
Sars Coronavirus Accessory ORFs Encode Luxury Functions
2006
Sars Cov Replication and Pathogenesis in Human Airway Airway Epithelial Cultures
2006
Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b
2006
SARS coronavirus replicase proteins in pathogenesis
2007
Mutational Analysis of MHV-A59 Replicase Protein-NSP10
2006
Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
2010
MHV-A59 Gene 1 Proteins are Associated with Two Distinct Membrane Populations
2001
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
2020 Standout
SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
2007
Sars Coronavirus Vaccine Development
2006
Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference
2019
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
2008
Persistent Replication of Severe Acute Respiratory Syndrome Coronavirus in Human Tubular Kidney Cells Selects for Adaptive Mutations in the Membrane Protein
2008
Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs
2005
Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production
2013
Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants
2007
Mouse Hepatitis Virus Replicase Proteins Associate with Two Distinct Populations of Intracellular Membranes
2000
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation
2016
Mouse Hepatitis Virus 3C-Like Protease Cleaves a 22-Kilodalton Protein from the Open Reading Frame 1a Polyprotein in Virus-Infected Cells and In Vitro
1998
Murine Hepatitis Virus Replicase Protein nsp10 Is a Critical Regulator of Viral RNA Synthesis
2007
The nsp2 Replicase Proteins of Murine Hepatitis Virus and Severe Acute Respiratory Syndrome Coronavirus Are Dispensable for Viral Replication
2005
Mechanisms of Zoonotic Severe Acute Respiratory Syndrome Coronavirus Host Range Expansion in Human Airway Epithelium
2007
Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme
2020
Analysis of Murine Hepatitis Virus Strain A59 Temperature-Sensitive Mutant TS-LA6 Suggests that nsp10 Plays a Critical Role in Polyprotein Processing
2007
Reverse Genetic Analysis of the Transcription Regulatory Sequence of the Coronavirus Transmissible Gastroenteritis Virus
2004
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
2018
Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63
2008
The Putative Helicase of the Coronavirus Mouse Hepatitis Virus Is Processed from the Replicase Gene Polyprotein and Localizes in Complexes That Are Active in Viral RNA Synthesis
1999
Synthetic Reconstruction of Zoonotic and Early Human Severe Acute Respiratory Syndrome Coronavirus Isolates That Produce Fatal Disease in Aged Mice
2007
SARS-like WIV1-CoV poised for human emergence
2016
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
2013
Severe Acute Respiratory Syndrome Coronavirus Group-Specific Open Reading Frames Encode Nonessential Functions for Replication in Cell Cultures and Mice
2005
Human Coronavirus HKU1 Spike Protein Uses O -Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme
2015
Cleavage between Replicase Proteins p28 and p65 of Mouse Hepatitis Virus Is Not Required for Virus Replication
2004
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