Citation Impact
Citing Papers
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
2008
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks
2006 Science
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
2008
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
2007
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
2014
PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination
2010 Science
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Collateral Damage from Antigen Receptor Gene Diversification
2008
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
2010
Mechanism and Regulation of Immunoglobulin Isotype Switching
1993
AID and mismatch repair in antibody diversification
2002
IL-10 selectively regulates murine Ig isotype switching
1996
IgH Class Switch Recombination to IgG1 in DNA-PKcs-Deficient B Cells
2002
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
2012 StandoutNobel
The role of the non‐homologous end‐joining pathway in lymphocyte development
2004
Two hypervarlable minisatellite DNA binding proteins
1991
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences
1993 StandoutNobel
The Immunoglobulin Class Switch: Beyond “Accessibility”
1997
Ku80 is required for immunoglobulin isotype switching
1998
Histone Modifications Associated with Somatic Hypermutation
2005
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Targeting of human switch recombination breakpoints: implications for the mechanism of μ - γ isotype switching
1999
Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes
2009
The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
2011
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
2003 Nature
Characterization of an endonuclease activity which preferentially cleaves the G-rich immunoglobulin switch repeat sequences
1996
An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells
1999
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
The mechanisms of immune diversification and their disorders
2003
Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes
2000 Nature
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
2010
NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: evidence for a double strand break intermediate
2006
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
1991 StandoutNobel
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
1999
The AID/APOBEC family of nucleic acid mutators
2008
Cellular, intracellular, and developmental expression patterns of murine SWAP-70
1999
Activation-induced cytidine deaminase: structure–function relationship as based on the study of mutants
2006
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
2003
A B-cell-specific DNA Recombination Complex
1998
Asymmetric mutation around the recombination break point of immunoglobulin class switch sequences on extrachromosomal substrates
1996
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
The influence of transcriptional orientation on endogenous switch region function
2003
AID and partners: for better and (not) for worse
2011
Sense transcription through the S region is essential for immunoglobulin class switch recombination
2011
Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats
2000
Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes
1993 Nobel
Purification and characterization of the immunoglobulin switch sequence-specific endonuclease (Endo-SR) from bovine spleen
1997
DNA sequences at immunoglobulin switch region recombination sites
1993
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination
2012
Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis
2012
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
2004
Complex regulation and function of activation-induced cytidine deaminase
2011
RNA: DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regualtion of class switch recombination
1995
Analysis of immunoglobulin Sgamma3 recombination breakpoints by PCR: implications for the mechanism of isotype switching
1997
SHMTool: A webserver for comparative analysis of somatic hypermutation datasets
2008
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
E-proteins directly regulate expression of activation-induced deaminase in mature B cells
2003
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Subpopulation analysis of drug‐induced cell‐cycle delay in human tumor cells using 90° light scatter
1988
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Unique and unprecedented recombination mechanisms in class switching
2000 StandoutNobel
AID Targeting in Antibody Diversity
2011
Transcriptional activation by LR1 at the Emicro enhancer and switch region sites
2000
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Stimulation of murine B lymphocytes induces a DNA exonuclease whose activity on switch-mu DNA is specifically inhibited by other germ-line switch region RNAs.
1998
Detection of an Immunoglobulin Switch Region-Specific DNA-Binding Protein in Mitogen-Stimulated Mouse Splenic B Cells
1990
THE EVOLUTION OF MULTIGENE FAMILIES: Human Haptoglobin Genes
1986 StandoutNobel
Linkage of the four gamma subclass heavy chain genes.
1981 StandoutNobel
Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes
1999
Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2
2003
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
2001 Nobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Stimulation of Murine B Lymphocytes Induces a DNA Exonuclease Whose Activity on Switch-μ DNA Is Specifically Inhibited by Other Germ-Line Switch Region RNAs
1998
DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
2007
Rad51 expression and localization in B cells carrying out class switch recombination.
1996
Fine-Structure Analysis of Activation-Induced Deaminase Accessibility to Class Switch Region R-Loops
2005
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
DNA-dependent Protein Kinase Activity Is Not Required for Immunoglobulin Class Switching
2002
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions
2002
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.
1993 StandoutNobel
Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
1997
XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
2011
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.
1989
Expression of a Microinjected Porcine Class I Major Histocompatibility Complex Gene in Transgenic Mice
1985 StandoutScienceNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
2018
Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.
1985 Nobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Molecular Characterization of Novel Reciprocal Translocation t(6;14) in an Epstein-Barr Virus-Transformed B Cell Precursor
1987 StandoutNobel
Mutations, Duplication, and Deletion of Recombined Switch Regions Suggest a Role for DNA Replication in the Immunoglobulin Heavy-Chain Switch
1989
IL-5 Induces IgG1 Isotype Switch Recombination in Mouse CD38-Activated sIgD-Positive B Lymphocytes
1999
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange
1984
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
2011
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning
1981 StandoutNatureNobel
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
2009 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region
2003
H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
2003
Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of CH Gene Switch Recombination
1998
The Biochemistry of Somatic Hypermutation
2008
The μ Switch Region Tandem Repeats Are Important, but Not Required, for Antibody Class Switch Recombination
2001
Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.
1982
Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.
1995
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes.
1986 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
1998
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination
2011
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
1996
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
Structure of the constant and 3′ untranslated regions of the murine Balb/c γ2a heavy chain messenger RNA
1980
Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes.
1983
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
2005
Works of Amy Kenter being referenced
Switch Recombination in a Transfected Plasmid Occurs Preferentially in a B Cell Line That Undergoes Switch Recombination of Its Chromosomal Ig Heavy Chain Genes
1999
Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney
2007
Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues
2007
Class-switch recombination: after the dawn of AID
2003
Class Switch Recombination: An Emerging Mechanism
2005
Protein Recognition Motifs of Sγ3 DNA Are Statistically Correlated with Switch Recombination Breakpoints
1992
S-S Synapsis during Class Switch Recombination Is Promoted by Distantly Located Transcriptional Elements and Activation-Induced Deaminase
2007
Switch recombination breakpoints occur at nonrandom positions in the S gamma tandem repeat.
1993
Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination.
1997
Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells.
1990
High expression of a 3'----5' exonuclease activity is specific to B lymphocytes.
1991
Mapping of a Functional Recombination Motif that Defines Isotype Specificity for μ→γ3 Switch Recombination Implicates NF-κB p50 as the Isotype-specific Switching Factor
2004
Chi, a promoter of generalized recombination in λ phage, is present in immunoglobulin genes
1981 Nature
Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins.
1992
AID-dependent histone acetylation is detected in immunoglobulin S regions
2006
S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination
2009
Genetic Mechanism Accounting for Precise Immunoglobulin Domain Deletion in a Variant of MPC 11 Myeloma Cells
1979 Science
High Expression of a 3′→5′ Exonuclease Activity Is Specific to B Lymphocytes
1991
Evidence for Class-Specific Factors in Immunoglobulin Isotype Switching
2000
The Liaison of Isotype Class Switch and Mismatch Repair
1999
Colcemid inhibits growth during early G1 in normal but not in tumorigenic lymphocytes
1986
Two New Isotype-Specific Switching Activities Detected for Ig Class Switching
2002
Immunoglobulin Switch Recombination May Occur by a DNA End‐Joining Mechanisma
1999
Cell cycle kinetics model of LPS-stimulated spleen cells correlates switch region rearrangements with S phase
1987