Standout Papers
Citation Impact
Citing Papers
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
2013 Standout
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
2019 StandoutNobel
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Pharmacologic Targeting of Hypoxia-Inducible Factors
2019 StandoutNobel
Ferroptosis: past, present and future
2020 Standout
Capture‐C reveals preformed chromatin interactions between HIF ‐binding sites and distant promoters
2016 StandoutNobel
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti–neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice
2008 StandoutNobel
Regulation of erythropoiesis by hypoxia-inducible factors
2013
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
2010
Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes
2015
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
2016
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
2016
Synapses and Alzheimer's Disease
2012 StandoutNobel
More than the sum of its parts? Nutrition in Alzheimer's disease
2010
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
2009
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Mechanisms of hypoxia signalling: new implications for nephrology
2019 StandoutNobel
Oxidative Stress Hypothesis in Alzheimer's Disease
1997 Standout
Lipid nanoparticles for mRNA delivery
2021 Standout
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
2022 StandoutNobel
Advances in metal-induced oxidative stress and human disease
2011 Standout
RNA delivery biomaterials for the treatment of genetic and rare diseases
2019
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
2019 Standout
Imaging-guided delivery of RNAi for anticancer treatment
2016
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
2014
The Science of Stroke: Mechanisms in Search of Treatments
2010 Standout
The current state and future directions of RNAi-based therapeutics
2019
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
2018
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
2021 StandoutNobel
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient
2016 Standout
Aptamers as therapeutics
2010 Standout
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Aptamers as targeted therapeutics: current potential and challenges
2016 Standout
The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications
2018
Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
2010
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
2004 Standout
The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
2016
Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
2014
Broadening horizons: the role of ferroptosis in cancer
2021 Standout
Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment
2018
DNA excision repair
2012 StandoutNobel
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
2020
Normal Functional Capacity in Circulating Myeloid and Plasmacytoid Dendritic Cells in Patients with Chronic Hepatitis C
2005 StandoutNobel
Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation
2008
The role of iron in brain ageing and neurodegenerative disorders
2014 Standout
CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo
2005 StandoutNobel
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
2010 Standout
Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology
2015 StandoutNobel
Electroporation-enhanced delivery of nucleic acid vaccines
2014
Anaemia in kidney disease: harnessing hypoxia responses for therapy
2015
The epigenetics of aging and neurodegeneration
2015
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals
2007
Changing perspectives regarding late-life dementia
2009
Pathogen Recognition and Innate Immunity
2006 Standout
Neuronal and Vascular Oxidative Stress in Alzheimers Disease
2011
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway
2021 StandoutNobel
New and emerging treatments for Alzheimer's disease
2012
The role of inflammation in depression: from evolutionary imperative to modern treatment target
2015 Standout
Omega-3 Fatty Acids as a Putative Treatment for Traumatic Brain Injury
2013
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
2020 Standout
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin
2016
Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
2015
Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges
2008
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
CpG Motifs in Bacterial DNA and Their Immune Effects
2002 Standout
Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms
2018
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
2018 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Prolyl 4‐hydroxylases, master regulators of the hypoxia response
2013
Role of Epigenetics in Alzheimer ‘S and Parkinson‘S Disease
2010
GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
2018
Lipids and Lipid Derivatives for RNA Delivery
2021
Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics
2017 StandoutNobel
Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies
2019
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
2021 StandoutNobel
Mechanisms of Renal Fibrosis
2017 Standout
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
2019 Standout
Works of Amy Chan being referenced
Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation
2012
Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression
2017
Increased Potency of an Aptameric G-Rich Oligonucleotide Is Associated with Novel Functional Properties of Phosphorothioate Linkages
1999
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
2017
Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification
2015
Dietary supplementation with a combination of α-lipoic acid, acetyl-l-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance
2009
Folate deprivation increases presenilin expression, gamma‐secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S‐adenosyl methionine
2007
Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis
2019
Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-year, Open-label Pilot Study With an 16-Month Caregiver Extension
2008
Dietary and genetically-induced oxidative stress alter tau phosphorylation: Influence of folate and apolipoprotein E deficiency
2006
Apple juice concentrate prevents oxidative damage and impaired maze performance in aged mice
2005
Dietary Supplementation with Apple Juice Decreases Endogenous Amyloid-β Levels in Murine Brain
2009
Dietary Deficiency in Folate and Vitamin E Under Conditions of Oxidative Stress Increases Phospho-Tau Levels: Potentiation by ApoE4 and Alleviation by S-Adenosylmethionine
2009
Phase I First-in-Humans Trial of ALN-TTRsc, a Novel RNA Interference Therapeutic for the Treatment of Familial Amyloidotic Cardiomyopathy (FAC)
2013
S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.
2007
Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
2008
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress
2006