A.M. Naylor

Postconditioning the Human Heart

Autonomic Nerve Development Contributes to Prostate Cancer Progression

Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters

Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010

Allosteric sites of phosphodiesterase‐5 (PDE5)

Acute Coronary Care in the Elderly, Part I

Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors

Acromegaly

Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial

Obstructive sleep apnoea inhibits the recovery of left ventricular function in patients with acute myocardial infarction

Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies

Intervention in acute coronary syndromes: do patients undergo intervention on the basis of their risk characteristics? The Global Registry of Acute Coronary Events (GRACE)

The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Universal Definition of Myocardial Infarction

Trends in case-fatality in 117718 patients admitted with acute myocardial infarction in Scotland

Unstable angina and non-Q wave myocardial infarction: does the clinical diagnosis have therapeutic implications?

Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (saruplase) in acute myocardial infarction: influence of heparin on early patency rate (LIMITS study)

Phosphodiesterase-5 Inhibition: the Molecular Biology of Erectile Function and Dysfunction

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention

Percutaneous Closure of Patent Foramen Ovale in Cryptogenic Embolism

Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes

Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin

Sildenafil citrate and blood-pressure–lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist

Erectile Dysfunction

Vasopressin release within the supraoptic and paraventricular nuclei of the rat brain: osmotic stimulation via microdialysis

Neural Control of the Lower Urinary Tract

Epidemiological classification of acute myocardial infarction: time for a change?

Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry

Zaprinast, a well‐known cyclic guanosine monophosphate‐specific phosphodiesterase inhibitor, is an agonist for GPR35

Transplantation of Neuronal and Glial Restricted Precursors into Contused Spinal Cord Improves Bladder and Motor Functions, Decreases Thermal Hypersensitivity, and Modifies Intraspinal Circuitry

Investigation of α₁‐adrenoceptor subtypes mediating vasoconstriction in rabbit cutaneous resistance arteries

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Cardiovascular safety of sildenafil citrate (Viagra®): An updated perspective

Hypothalamic oxytocin in the developing ovine fetus: interaction with pituitary–adrenocortical function

Identification and Regulation of Human PDE5A Gene Promoter

α 2-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons

Patients With Prolonged Ischemic Chest Pain and Presumed-New Left Bundle Branch Block Have Heterogeneous Outcomes Depending on the Presence of ST-Segment Changes

Influence of Diabetes Mellitus on Clinical Outcome in the Thrombolytic Era of Acute Myocardial Infarction fn1fn1The GUSTO-I study was supported by a combined grant from Bayer, New York, New York; CIBA-Corning, Medfield, Massachusetts; Genetech, South San Francisco, California; ICI Pharmaceuticals, Wilmington, Delaware; and Sanofi Pharmaceuticals, Paris, France.

Intra-arterial Prourokinase for Acute Ischemic Stroke

2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)

α1-Adrenergic Receptor Subtype mRNAs Are Differentially Regulated by α1-Adrenergic and Other Hypertrophic Stimuli in Cardiac Myocytes in Culture and In Vivo

Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

Cardiogenic shock complicating acute myocardial infarction—etiologies, management and outcome: a report from the SHOCK Trial Registry

Sex and gender: modifiers of health, disease, and medicine

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

Chronic sildenafil in men with diabetes and erectile dysfunction

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration

Diabetes and Atherosclerosis

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

Assessing the quality of controlled clinical trials

Tamsulosin

Tadalafil Improved Erectile Function at Twenty‐Four and Thirty‐Six Hours After Dosing in Men With Erectile Dysfunction: US Trial

Cardiogenic shock with non-ST-segment elevation myocardial infarction: a report from the SHOCK Trial Registry

Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3'5' guanosine monophosphate accumulation in retinal pigment epithelium cells

Regulation of Human PDE5A2 Intronic Promoter by cAMP and cGMP: Identification of a Critical Sp1-Binding Site

Antithrombotic Therapy in the Elderly

Phosphorylation of phosphodiesterase‐5 by cyclic nucleotide‐dependent protein kinase alters its catalytic and allosteric cGMP‐binding activities

Sickle-cell disease

Detecting differences in quality of care: the sensitivity of measures of process and outcome in treating acute myocardial infarction

Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000

Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

Myocardial Reperfusion Injury

Revisiting Reperfusion Therapy in Inferior Myocardial Infarction

The Electrocardiogram Predicts One-Year Outcome of Patients With Unstable Angina and Non–Q Wave Myocardial Infarction: Results of the TIMI III Registry ECG Ancillary Study fn1fn1The TIMI III Clinical Centers are supported by Grant R01-HL42311 and the Data Coordinating Center by Grant R01-HL42428 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Additional support was supplied by Genentech, Inc., South San Francisco, California.

Cholinergic innervation and function in the prostate gland

Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies

Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina

Reporting of Noninferiority and Equivalence Randomized Trials

Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study

Sildenafil citrate does not affect cardiac contractility in human or dog heart

The Na+/H+exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction11This manuscript is dedicated to the memory of Karl-Ludwig Neuhaus (1944–2000).

The TIMI Risk Score for Unstable Angina/Non–ST Elevation MI

Special Invited Papers Section: Therapeutic Equivalence – Clinical Issues and Statistical Methodology in Noninferiority Trials

2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies

Obstructive sleep apnoea and its cardiovascular consequences

External validity of randomised controlled trials: “To whom do the results of this trial apply?”

Effect of age on outcome with primary angioplasty versus thrombolysis

The Calcium/Calmodulin-dependent Phosphodiesterase PDE1C Down-regulates Glucose-induced Insulin Secretion

Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT_3AReceptor Subunit

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study

The Novel Functions of cGMP-Specific Phosphodiesterase 5 and its Inhibitors in Carcinoma Cells and Pulmonary/Cardiovascular Vessels

In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach

Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

Reperfusion therapy in elderly patients with acute myocardial infarction

2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients With Unstable Angina/ Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline)

Contribution of modern cardiovascular treatment and risk factor changes to the decline in coronary heart disease mortality in Scotland between 1975 and 1994

Clinical characteristics and outcome of patients with early (<2h), intermediate (2–4h) and late (>4h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

Explanation for the Decline in Coronary Heart Disease Mortality Rates in Auckland, New Zealand, Between 1982 and 1993

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: Executive Summary

Task force 5. Stratification of patients into high, medium and low risk subgroups for purposes of risk factor management

Toward a New Frontier in Myocardial Reperfusion Therapy

ACC/AHA guidelines for coronary angiography11“ACC/AHA Guidelines for Coronary Angiography” was approved by the American College of Cardiology Board of Trustees in October 1998 and by the American Heart Association Science Advisory and Coordinating Committee in December 1998.22When citing this document, the American College of Cardiology and the American Heart Association request that the following format be used: Scanlon PJ, Faxon DP, Audet AM, Carabello B, Dehmer GJ, Eagle KA, Legako RD, Leon DF, Murray JA, Nissen SD, Pepine CJ, Watson RM. ACC/AHA guidelines for coronary angiography: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography). J Am Coll Cardiol1999;33:1756–82433This document is available on the websites of the ACC (www.acc.org) and the AHA (www.americanheart.org). Reprints of this document (the complete guidelines) are available for $5 each by calling 800-253-4636 (US only) or writing the American College of Cardiology, Educational Services, 9111 Old Georgetown Road, Bethesda, MD 20814-1699. Ask for reprint No. 71-0164. To obtain a reprint of the shorter version (executive summary and summary of recommendations) published in the May 4, 1999, issue of Circulation, ask for reprint No. 71-0163. To purchase additional reprints (specify version and reprint number): up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 214-706-1466, fax 214-691-6342, or e-mail pubauth@heart.org

2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery

Acute Myocardial Infarction in Women

Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management

Decreased blood pressure response in mice deficient of the α _1b -adrenergic receptor

Stroke in Patients With Acute Coronary Syndromes

Relevance of clinical trial results in myocardial infarction to medical practice: comparison of four year outcome in participants of a thrombolytic trial, patients receiving routine thrombolysis, and those deemed ineligible for thrombolysis

G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression

EXPERIMENTAL BLADDER INSTABILITY FOLLOWING BLADDER OUTLET OBSTRUCTION IN THE FEMALE RAT

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A

Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α_2BAdrenoceptors

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline)

V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats

Does PTCA in Acute Myocardial Infarction Affect Mortality and Reinfarction Rates?

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies

Age and Outcome With Contemporary Thrombolytic Therapy

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

The Oxytocin Receptor System: Structure, Function, and Regulation

General Cardiovascular Risk Profile for Use in Primary Care

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention

Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction

Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

ACC/AHA Guidelines for Percutaneous Coronary Intervention (Revision of the 1993 PTCA Guidelines)—Executive Summary

Weekend versus Weekday Admission and Mortality from Myocardial Infarction

2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

Pharmacological Options in the Treatment of Benign Prostatic Hyperplasia

The Insulin-Like Growth Factor Type I Receptor Stimulates Growth and Suppresses Apoptosis in Prostatic Stromal Cells

Evaluation of the pharmacological selectivity profile of α₁ adrenoceptor antagonists at prostatic α₁ adrenoceptors: binding, functional and in vivo studies

Effect of alpha, adrenoceptorantagonists on prostatic pressure and blood pressure in the anesthetized dog

Interactions between neuropeptide Y, luteinizing hormone-releasing hormone and estradiol in the control of luteinizing hormone release from cultured ovine pituitary cells

Characterization of an α_1D‐adrenoceptor mediating the contractile response of rat aorta to noradrenaline

An investigation of the effects of zaprinast, a PDE inhibitor, on the nitrergic control of the urethra in anaesthetized female rats

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

Pharmacological properties of the cloned α_1A/D‐adrenoceptor subtype are consistent with the α_1A‐adrenoceptor characterized in rat cerebral cortex and vas deferens

The role of vasopressin as an antipyretic in the ventral septal area and its possible involvement in convulsive disorders

Micturition in conscious rats with and without bladder outlet obstruction: role of spinal α₁‐adrenoceptors

Evidence supporting a role for endogenous vasopressin in fever suppression in the rat.

Science of urinary incontinence

Section Review Central & Peripheral Nervous Systems: α₁-Adrenoceptor antagonists as treatments for benign prostatic hyperplasia

Antipyretic action of centrally administered arginine vasopressin but not oxytocin in the cat

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES