Standout Papers
Citation Impact
Citing Papers
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
A bacterium that degrades and assimilates poly(ethylene terephthalate)
2016 StandoutScience
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling
2015
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate
2016
Precisely patterned nanofibres made from extendable protein multiplexes
2023 StandoutNobel
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
2015
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species
2015
Metabolic regulation of NLRP 3
2017
Biomolecular condensates: organizers of cellular biochemistry
2017 Standout
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Unravelling biological macromolecules with cryo-electron microscopy
2016 Nature
NF-κB signaling in inflammation
2017 Standout
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
2018
Necroptosis and its role in inflammation
2015 StandoutNature
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
2016 Standout
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
2018 Nature
COPs and POPs Patrol Inflammasome Activation
2017
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
2017
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement
2015 StandoutNobel
Hallmarks of aging: An expanding universe
2023 Standout
Molecular mechanisms regulating NLRP3 inflammasome activation
2015 Standout
Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I
2014
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
2016
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
2015
Molecular Dynamics Simulation for All
2018 Standout
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease
2015
NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
2017
The inflammasome pathway in stable COPD and acute exacerbations
2016
Targeting the NLRP3 inflammasome in inflammatory diseases
2018
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
2017 Nature
Mechanisms of inflammasome activation: recent advances and novel insights
2015
Neutrophil extracellular traps in immunity and disease
2017 Standout
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
2016
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Periodontitis: from microbial immune subversion to systemic inflammation
2014 Standout
Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation
2015
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
2018
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
2020 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response
2014
Near-Atomic Resolution for One State of F-Actin
2014
A glass menagerie of low complexity sequences
2016
Mechanisms and Functions of Inflammasomes
2014 Standout
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
2016
A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death
2017
Post-Translational Modification Control of Innate Immunity
2016
Mitochondria as multifaceted regulators of cell death
2019 Standout
Enzymes for the Biofunctionalization of Poly(Ethylene Terephthalate)
2010
Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies
2015 StandoutNobel
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
2014
Isotherms of individual pores by gas adsorption crystallography
2019 StandoutNobel
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
2015 Standout
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
2018 Nature
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Human Monocytes Engage an Alternative Inflammasome Pathway
2016
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
2015
ATP-Dependent Effector-like Functions of RIG-I-like Receptors
2015 StandoutNobel
The intersection of cell death and inflammasome activation
2016
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Tranilast directly targets NLRP 3 to treat inflammasome‐driven diseases
2018
Crystal structure of a feruloyl esterase belonging to the tannase family: A disulfide bond near a catalytic triad
2014
GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells
2015
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
State of the Art and Prospects in Metal–Organic Framework (MOF)-Based and MOF-Derived Nanocatalysis
2019 Standout
NLRP3 recruitment by NLRC4 during Salmonella infection
2016
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy
2015
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
2017
Negative regulation of the inflammasome: keeping inflammation under control
2015
NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx
2016
Toward Design Rules for Enzyme Immobilization in Hierarchical Mesoporous Metal-Organic Frameworks
2016
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
2014
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
2017
A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis
2019 StandoutNobel
Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing
2015
Ambiguities in helical reconstruction
2014
A noncanonical function of cGAMP in inflammasome priming and activation
2017
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
2017
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming
2018
Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease
2017
Transport properties in porous coordination polymers
2020 StandoutNobel
The NAIP –NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
2015
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Regulation of inflammasome activation
2015
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Polymer physics of intracellular phase transitions
2015
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Caspase‐8: regulating life and death
2017 Standout
Structural and biochemical basis for induced self-propagation of NLRC4
2015 Science
Works of Alvin Lu being referenced
The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments
2015
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
2015
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
2013
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
2016
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
2016
Structural mechanisms of inflammasome assembly
2014
Structural and Functional Studies of Aspergillus oryzae Cutinase: Enhanced Thermostability and Hydrolytic Activity of Synthetic Ester and Polyester Degradation
2009
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
2015 Science
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
2016