Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
2003 StandoutScience
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
A completely foreign receptor can mediate an interferon-gamma-like response
2001
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
2000 StandoutNobel
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Pim serine/threonine kinases regulate the stability of Socs-1 protein
2002
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
2013
The F-box protein TIR1 is an auxin receptor
2005 StandoutNature
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Inflammation and cancer
2002 StandoutNature
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Inflammation and metabolic disorders
2006 StandoutNature
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
2004 StandoutNature
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Oncogenic kinase signalling
2001 StandoutNature
A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box
2001
Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation
2000
TRIM8/GERP RING Finger Protein Interacts with SOCS-1
2002
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase
2003 StandoutNobel
The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2
2001
Feedback control of intercellular signalling in development
2000 Nature
SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2
2002
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The von Hippel–Lindau tumor suppressor protein
2001 StandoutNobel
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
2000
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
2007 StandoutNature
Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells
2002
A new high affinity binding site for suppressor of cytokine signaling‐3 on the erythropoietin receptor
2002
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
2002
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
2003
Oncostatin M Regulates the Synthesis and Turnover of gp130, Leukemia Inhibitory Factor Receptor α, and Oncostatin M Receptor β by Distinct Mechanisms
2001
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
2002
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
2000
Immunity, Inflammation, and Cancer
2010 Standout
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
2000
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Immunity by ubiquitylation: a reversible process of modification
2005
The cancer stem cell: premises, promises and challenges
2011 Standout
CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2
2000
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
2008
Formation of the VHL–Elongin BC Tumor Suppressor Complex Is Mediated by the Chaperonin TRiC
1999
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor
2001
STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
2008
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
2003
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
2001
Cytokine Signaling in 2002
2002 Standout
Attenuation of leptin and insulin signaling by SOCS proteins
2006
CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
2000
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
2006
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
1999
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Positive and Negative Selection of T Cells
2003
Protein–protein interactions define specificity in signal transduction
2000
Interleukin -10and Related Cytokines and Receptors
2004
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
2003
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Advances in skin grafting and treatment of cutaneous wounds
2014 StandoutScience
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
2000
Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation
2001
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1
2002
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
SOCS Proteins: Negative Regulators of Cytokine Signaling
2001 Standout
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985
2000
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner
2004 StandoutNobel
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
2001
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction
2002
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
2000
Protein tyrosine phosphatase εC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling
2001
Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation
2001
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
2002
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Tracking adult stem cells
2011
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
2002
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
2001
Plasticity of epithelial stem cells in tissue regeneration
2014 Science
Works of Alison Farley being referenced
Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells
2008
Identification and Characterization of Thymic Epithelial Progenitor Cells
2002
Negative Regulation of Cytokine Signaling by the SOCS Proteins
1999
Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells
2010 Nature
Suckling defect in mice lacking the soluble haemopoietin receptor NR6
1999
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
1999
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
2000