Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
The amyloid precursor protein: beyond amyloid.
2006
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
2005
Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
2013
Synapses and Alzheimer's Disease
2012 StandoutNobel
Critical period plasticity in local cortical circuits
2005 Standout
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
Disruption of Axonal Transport and Neuronal Viability by Amyloid Precursor Protein Mutations in Drosophila
2001
Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro
2003
Neurotrophin regulation of neural circuit development and function
2012 Standout
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Glutamate uptake
2001 Standout
The use of the hippocampal slice preparation in the study of Alzheimer's disease
2008
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile
2012
Pretraining and the Function of Hippocampal Long-Term Potentiation
2000 StandoutNobel
WNT and β-catenin signalling: diseases and therapies
2004 Standout
Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2
2005
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
2010
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005
New excitement in cognitive space: between place cells and spatial memory
2001 StandoutNobel
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
2020 StandoutNobel
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
Frequency of gamma oscillations routes flow of information in the hippocampus
2009 StandoutNatureNobel
A quantitative assessment of hERG liability as a function of lipophilicity
2006
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
2005 Standout
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
2001 Nature
Stress and the brain: from adaptation to disease
2005 Standout
The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice
2007
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
2003 Standout
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Alzheimer's Disease
2010 Standout
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
2012
LTP and LTD
2004 Standout
Can molecules explain long-term potentiation?
1999
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
1999
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
2012
The amyloid state and its association with protein misfolding diseases
2014 Standout
Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology
2002
A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides
2008 StandoutNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration
2006 Standout
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The past, the future and the biology of memory storage
1999 StandoutNobel
Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein
2001
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
2001
A theory of cortical responses
2005 Standout
G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges
2015
Role of High-Affinity Receptors and Membrane Transporters in Nonsynaptic Communication and Drug Action in the Central Nervous System
2000
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity
2011
Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory
2003 StandoutNobel
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
AMPA Receptor Trafficking and Synaptic Plasticity
2002 Standout
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Oxadiazole isomers: all bioisosteres are not created equal
2012
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
2000 Standout
Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?
2011
Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase
2001
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
2000 Standout
Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
2002
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
2006 Standout
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation
2005 StandoutNobel
Retrograde Amnesia for Spatial Memory Induced by NMDA Receptor-Mediated Long-Term Potentiation
2001 StandoutNobel
Works of Alison Easter being referenced
Modulation of Long-term Potentiation in CA1 Region of Mouse Hippocampal Brain Slices by GABAA Receptor Benzodiazepine Site Ligands
1997
Approaches to seizure risk assessment in preclinical drug discovery
2009
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
2010
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
2006
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein
1999
Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™
2007
Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists
2014