Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
2003 Standout
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
2002 StandoutScience
Ovarian Sex Steroid-Dependent Plasticity of Nociceptin/Orphanin FQ and Opioid Modulation of Spinal Dynorphin Release
2001
Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord
1999
Opioids in chronic pain
2001
Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8
2002
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
1998 Standout
Acromegaly
2006 Standout
Modulation of Synaptic Transmission by Nociceptin/Orphanin FQ and Nocistatin in the Spinal Cord Dorsal Horn of Mutant Mice Lacking the Nociceptin/Orphanin FQ Receptor
2001
Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia
1999
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices
1998
Orphanin FQ is a functional anti-opioid peptide
1996
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more
1998
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease
2001
Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies
2002 Standout
Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
1997
Transgenic studies of pain
1998
Bone marrow cells regenerate infarcted myocardium
2001 StandoutNature
Descending control of pain
2002 Standout
Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors
2001
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-d-aspartate-evoked responses
1999
OPIOID RECEPTOR SIGNALLING MECHANISMS
1999
Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes
2006
Nocistatin, a peptide that blocks nociceptin action in pain transmission
1998 Nature
Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat
2000
Evolution of POMC: origin, phylogeny, posttranslational processing, and the melanocortins
2011
Toward the active conformations of rhodopsin and the β2‐adrenergic receptor
2004
An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin
2001
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
2002 Standout
The GPR54 Gene as a Regulator of Puberty
2003 Standout
Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture
1998
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice
2001 StandoutNobel
Selectivity of μ-opioid receptor determined by interfacial residues near third extracellular loop
2000
Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice
2002
Functional genomics: the search for novel neurotransmitters and neuropeptides
1998
Direct Activation of a GATA6 Cardiac Enhancer by Nkx2.5: Evidence for a Reinforcing Regulatory Network of Nkx2.5 and GATA Transcription Factors in the Developing Heart
2000
Creating a Functional Opioid Alkaloid Binding Site in the Orphanin FQ Receptor through Site-Directed Mutagenesis
1998
Effects of microinjection of OFQ into PAG on spinal dorsal horn WDR neurons in rats
2001
Blockade effects of (Nphe1)Nociceptin(1–13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats
2001
Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo
1996
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Orphan G-protein-coupled receptors and natural ligand discovery
2001
Functional Blockade of Opioid Analgesia by Orphanin FQ/Nociceptin
1998
Pharmacology of nociceptin and its receptor: a novel therapeutic target
2000
Ghrelin induces adiposity in rodents
2000 StandoutNature
Central nervous system control of food intake
2000 StandoutNature
Roles of JUMONJI in mouse embryonic development
2004
Inhibition of nociceptin‐induced allodynia in conscious mice by prostaglandin D2
1997
Expression of immediate early genes, GATA‐4, and Nkx‐2.5 in adrenergic‐induced cardiac hypertrophy and during regression in adult mice
1999
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
The Impact of Cardiac Natriuretic Peptide Determination on the Diagnosis and Management of Heart Failure
2001
Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons*
2010 StandoutNobel
Models and Mechanisms of Hyperalgesia and Allodynia
2009
Persistent postsurgical pain: risk factors and prevention
2006 Standout
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
2002 StandoutNobel
Control of Cardiac Development by an Evolutionarily Conserved Transcriptional Network
2002
Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe1)nociceptin(1–13)NH2
2001
Loss of Antinociception Induced by Naloxone Benzoylhydrazone in Nociceptin Receptor-Knockout Mice
1998
Antagonism of ORL1 receptor produces an algesic effect in the rat formalin test
2001
Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells
2003 StandoutNobel
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
2001
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse
2001
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
2002
A Cellular Mechanism for the Bidirectional Pain-Modulating Actions of Orphanin FQ/Nociceptin
2000
Distinct effect of orphanin FQ in nucleus raphe magnus and nucleus reticularis gigantocellularis on the rat tail flick reflex
2001
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Effects of supraspinal orphanin FQ/nociceptin
2000
Morphine Activates Opioid Receptors without Causing Their Rapid Internalization
1996
Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor
2000
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
2010 Standout
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations
2001
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
2007 StandoutNobel
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
1997
Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of μ-, δ- or κ-opioid receptor knockout mice
2001
Bidirectional actions of nociceptin/orphanin FQ on Aδ-fibre-evoked responses in rat superficial spinal dorsal horn in vitro
2001
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice
1999
Bidirectional modulatory effect of orphanin FQ on morphine‐induced analgesia: antagonism in brain and potentiation in spinal cord of the rat
1997
M-CAT, CArG, and Sp1 Elements Are Required for α1-Adrenergic Induction of the Skeletal α-Actin Promoter during Cardiac Myocyte Hypertrophy
1995
Nociceptin/orphanin FQ: role in nociceptive information processing
1999
Seven-transmembrane receptors
2002 StandoutNobel
Analgesia elicited by OFQ/nociceptin and its fragments from the amygdala in rats
2001
Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats
1999
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
Ghrelin: Structure and Function
2005 Standout
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
1997 Standout
Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro
2001
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
1998 Standout
Morphine tolerance and dependence in nociceptin/orphanin fq transgenic knock-out mice
2001
Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
1999
Unaltered peripheral excitatory actions of nociceptin contrast with enhanced spinal inhibitory effects after carrageenan inflammation: an electrophysiological study in the rat
2000
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Molecular characterization of the melanin-concentrating-hormone receptor
1999 Nature
GATA-dependent recruitment of MEF2 proteins to target promoters
2000
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Anti‐nociceptive responses produced by human putative counterpart of nocistatin
1998
ORL-1 and Mu opioid receptor antisera label different fibers in areas involved in pain processing
1998
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
1995
Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure
2002 Standout
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance
2004 StandoutNobel
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex.
1996
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
2001 Standout
Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
2000
A prolactin-releasing peptide in the brain
1998 Nature
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
Circuitry Underlying AntiOpioid Actions of Orphanin FQ in the Rostral Ventromedial Medulla
1997
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
1999
A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.
1994
The structural basis of g-protein-coupled receptor function and dysfunction in human diseases
2007
Selective Suppression of Inhibitory Synaptic Transmission by Nocistatin in the Rat Spinal Cord Dorsal Horn
2000
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Potentiation of Opioid Analgesia in Dopamine2Receptor Knock-Out Mice: Evidence for a Tonically Active Anti-Opioid System
2001
Inhibition of Transcription Factor GATA-4 Expression Blocks In Vitro Cardiac Muscle Differentiation
1995
Effect of Intrathecal Nocistatin on the Formalin-Induced Pain in Mice Versus That of Nociceptin/Orphanin FQ
2000
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Tandem Facial Amphiphiles for Membrane Protein Stabilization
2010 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Autoradiographic localization of125I[Tyr14]orphanin FQ/nociceptin and125I[Tyr10]orphanin FQ/nociceptin(1-11) binding sites in rat brain
2000
Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-gal histochemistry in receptor-deficient mice
2000
Prospects for inferring very large phylogenies by using the neighbor-joining method
2004 Standout
α1-Adrenergic Receptor Subtypes
1996
Jumonji, a Nuclear Protein That Is Necessary for Normal Heart Development
2000
cis -Acting Sequences That Mediate Induction of β-Myosin Heavy Chain Gene Expression During Left Ventricular Hypertrophy due to Aortic Constriction
1997
The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ
1997
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with125I-[14Tyr]-orphanin FQ binding
1999
Preterm labor: One syndrome, many causes
2014 StandoutScience
Emerging Molecular Approaches to Pain Therapy
1999
A Hormone-Encoding Gene Identifies a Pathway for Cardiac but Not Skeletal Muscle Gene Transcription
1994
Involvement of Multiple cis Elements in Basal- and α-Adrenergic Agonist–Inducible Atrial Natriuretic Factor Transcription
1995
Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor
2002
Emerging Targets in Photopharmacology
2016 StandoutNobel
The Molecular and Behavioral Pharmacology of the Orphanin FQ/Nociceptin Peptide and Receptor Family
2001
Monitoring the function of membrane transport proteins in detergent-solubilized form
2007
Pain Genes?: Natural Variation and Transgenic Mutants
2000
Neuroendocrine Mechanisms in Pregnancy and Parturition
2010
Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription
1999
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
1999
Antianalgesic Action of Nociceptin Originating in the Brain Is Mediated by Spinal Prostaglandin E2 in Mice
2001
Pronociceptive Effects of Nociceptin/Orphanin FQ (13–17) at Peripheral and Spinal Level in Mice
2001
Works of Ali Ardati being referenced
Interaction of [3H]Orphanin FQ and125I-Tyr14-Orphanin FQ with the Orphanin FQ Receptor: Kinetics and Modulation by Cations and Guanine Nucleotides
1997
Human CRF2 α and β splice variants: pharmacological characterization using radioligand binding and a luciferase gene expression assay
1999
Minireview: Orphan Receptors and their Natural Ligands
1997
Structure-Activity Relationship Studies on the Novel Neuropeptide Orphanin FQ
1996
Moving from the Orphanin FQ Receptor to an Opioid Receptor Using Four Point Mutations
1996
A new family of orphan G protein‐coupled receptors predominantly expressed in the brain1
1998
The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium
1996
A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.
1993
Primary structure and tissue distribution of the orphanin FQ precursor.
1996
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
1995 StandoutScience
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells
1994
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.
1994