Citation Impact
Citing Papers
Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling
2007
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
2009 StandoutNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
2008
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins
2003 Science
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2
2004
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein
2009
Src kinase activation by direct interaction with the integrin β cytoplasmic domain
2003
Fuzziness: linking regulation to protein dynamics
2011
Intrinsically disordered regions as affinity tuners in protein–DNA interactions
2011
Quinary protein structure and the consequences of crowding in living cells: Leaving the test‐tube behind
2013
Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion
2005 StandoutNobel
Tests of the Extension and Deadbolt Models of Integrin Activation
2007
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
Regulation of C-type Lectin Antimicrobial Activity by a Flexible N-terminal Prosegment
2008
Linking integrin conformation to function
2008
The role of dynamic conformational ensembles in biomolecular recognition
2009 Standout
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
2003
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Integrin Structure, Activation, and Interactions
2011
The ankyrin repeat as molecular architecture for protein recognition
2004
Probing Slow Chemical Exchange at Carbonyl Sites in Proteins by Chemical Exchange Saturation Transfer NMR Spectroscopy
2013
Membrane-proximal α/β Stalk Interactions Differentially Regulate Integrin Activation
2005
Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement
2003
Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans
2004
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
2012 StandoutNobel
Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review)
2008
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction
2009
Structural mechanism of integrin inactivation by filamin
2015
Protein dynamics and conformational disorder in molecular recognition
2009
Structural Basis of Integrin Activation by Talin
2007
Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts
2019
Evidence That Monoclonal Antibodies Directed against the Integrin β Subunit Plexin/Semaphorin/Integrin Domain Stimulate Function by Inducing Receptor Extension
2004
High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy
2014 StandoutNobel
The Human Transcription Factors
2018 Standout
Chemical shift-based methods in NMR structure determination
2018
Genetic Analyses of Integrin Signaling
2010
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo
2010
The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3
2009 StandoutNobel
Structure and Intrinsic Disorder in Protein Autoinhibition
2013
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
2021
Extracellular Proteins Organize the Mechanosensory Channel Complex in C. elegans Touch Receptor Neurons
2004 StandoutNobel
Scleroderma
2009 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Chemotaxis: signalling the way forward
2004
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
A Coiled-Coil Structure of the αIIbβ3 Integrin Transmembrane and Cytoplasmic Domains in Its Resting State
2005
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
The LIM domain: from the cytoskeleton to the nucleus
2004
Multiple frequency saturation pulses reduce CEST acquisition time for quantifying conformational exchange in biomolecules
2018
Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR
2007
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Phase transitions in the assembly of multivalent signalling proteins
2012 StandoutNature
Linking folding and binding
2009
Exploring methods to expedite the recording of CEST datasets using selective pulse excitation
2018
A new class of CEST experiment based on selecting different magnetization components at the start and end of the CEST relaxation element: an application to 1H CEST
2018
Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions
2007
Integrin structures and conformational signaling
2006
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
2007 StandoutNobel
Allosteric β1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain
2004
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
2012 Standout
Distinct Subsets of Syt-IV/BDNF Vesicles Are Sorted to Axons versus Dendrites and Recruited to Synapses by Activity
2012 StandoutNobel
The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling
2009
Structure of the Integrin αIIb Transmembrane Segment
2008
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
2007
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
2004 Nature
Intracellular signalling controlling integrin activation in lymphocytes
2005
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle
2007
Therapeutic antagonists and conformational regulation of integrin function
2003
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin
2007
A Putative Src Homology 3 Domain Binding Motif but Not the C-terminal Dystrophin WW Domain Binding Motif Is Required for Dystroglycan Function in Cellular Polarity in Drosophila
2007 StandoutNobel
C. elegans PAT-6/Actopaxin Plays a Critical Role in the Assembly of Integrin Adhesion Complexes In Vivo
2003
Integrins
2002 Standout
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2
2010
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
The talin–tail interaction places integrin activation on FERM ground
2004
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
2002
Transmembrane Domain Helix Packing Stabilizes Integrin αIIbβ3 in the Low Affinity State
2005
Regulation of Integrin Activation
2011
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
2017 StandoutNobel
Dynamic protein–DNA recognition: beyond what can be seen
2011
Structure, Dynamics, Assembly, and Evolution of Protein Complexes
2014
Structural and Energetic Basis of Allostery
2012
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
A push-pull mechanism for regulating integrin function
2005
Structural Basis of Integrin Regulation and Signaling
2007
Trapping Moving Targets with Small Molecules
2009 Science
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Structure of the Integrin β3 Transmembrane Segment in Phospholipid Bicelles and Detergent Micelles
2008
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
2005
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering
2005
SWISS-MODEL: homology modelling of protein structures and complexes
2018 Standout
Exploring and Engineering the Cell Surface Interface
2005 StandoutScience
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Talin controls integrin activation
2004
A Naturally Occurring Extracellular α−β Clasp Contributes to Stabilization of β3 Integrins in a Bent, Resting Conformation
2008
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces
2020 StandoutNobel
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
2018 Standout
Supramolecular Assemblies of a Conjugate of Nucleobase, Amino Acids, and Saccharide Act as Agonists for Proliferation of Embryonic Stem Cells and Development of Zygotes
2014
A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
2004
The Tail of Integrins, Talin, and Kindlins
2009 Science
Membrane-mediated structural transitions at the cytoplasmic face during integrin activation
2004
Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails
2008
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
2003
Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions
2004
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
2003 Science
Works of Algirdas Vėlyvis being referenced
A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase
2007
Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region
2005 Science
Structural and functional insights into PINCH LIM4 domain–mediated integrin signaling
2003
Solution NMR of supramolecular complexes: providing new insights into function
2007
Solution Structure of the Focal Adhesion Adaptor PINCH LIM1 Domain and Characterization of Its Interaction with the Integrin-linked Kinase Ankyrin Repeat Domain
2001
Application of Methyl-TROSY NMR to Test Allosteric Models Describing Effects of Nucleotide Binding to Aspartate Transcarbamoylase
2009
13CHD2–CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins
2015
A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face
2002
Structure of an Ultraweak Protein-Protein Complex and Its Crucial Role in Regulation of Cell Morphology and Motility
2005
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
2002
Quantifying Millisecond Exchange Dynamics in Proteins by CPMG Relaxation Dispersion NMR Using Side-Chain 1H Probes
2012
Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions
2018
Cross-Validation of the Structure of a Transiently Formed and Low Populated FF Domain Folding Intermediate Determined by Relaxation Dispersion NMR and CS-Rosetta
2011
A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle
2020